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Do we need a more individualised approach to the management of comorbid depression and diabetes?

Part of: BJPsych Advances Cochrane Corner and Round the Corner Collection

Published online by Cambridge University Press:  30 July 2024

Surina Moodley Open the ORCID record for Surina Moodley [Opens in a new window]  and
Panagiotis Pavlou
Surina Moodley*
Affiliation:
Foundation doctor currently working within the Oxford Health NHS Foundation Trust, Oxford, UK. She wishes to pursue training in internal medicine and has an interest in exploring how chronic medical conditions affect mental health.
Panagiotis Pavlou
Affiliation:
Specialty registrar in endocrinology and diabetes currently working in Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK. His main interests lie in the prevention and treatment of complications of diabetes through the recognition of the crucial role of diabetes psychology in the management of the illness and its effect on long-term outcomes.
*
Correspondence Surina Moodley. Email: Surina.Moodley@ouh.nhs.uk
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Summary

Diabetes and depression have a bidirectional relationship, but some antidepressants (such as the tricyclics) may have detrimental effects in diabetes that are exacerbated by behavioural changes associated with depression. This month's Cochrane Review evaluated the efficacy of psychological and pharmacological treatments of comorbid depression in diabetes and found that such interventions have a moderate and clinically significant effect on depression outcomes in people with diabetes. However, conclusions were limited by significant heterogeneity within examined populations and interventions, and significant risk of bias within trials. This commentary critically appraises the review and aims to contextualise its findings.

Keywords

Depressive disordersrandomised controlled trialantidepressantsexperimental designstatistical methodology
Type
Round the corner
Information
BJPsych Advances , Volume 30 , Issue 5 , September 2024 , pp. 267 - 270
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Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press on behalf of Royal College of Psychiatrists

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Footnotes

†

Commentary on… Psychological and pharmacological interventions for depression in patients with diabetes mellitus and depression (Cochrane Corner). See this issue.

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