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Clinical characteristics associated with hospital-onset bacteremia and fungemia among cancer and transplant patients

Published online by Cambridge University Press:  23 October 2024

Kalvin C. Yu Open the ORCID record for Kalvin C. Yu [Opens in a new window] ,
John C. O’Horo Open the ORCID record for John C. O’Horo [Opens in a new window] ,
ChinEn Ai ,
Molly Jung Open the ORCID record for Molly Jung [Opens in a new window]  and
Samantha Bastow Open the ORCID record for Samantha Bastow [Opens in a new window]
Kalvin C. Yu*
Affiliation:
Dept. of Medical Affairs, Becton Dickinson and Company, Franklin Lakes, NJ, USA
John C. O’Horo
Affiliation:
Mayo Clinic, Rochester, MN, USA
ChinEn Ai
Affiliation:
Dept. of Medical Affairs, Becton Dickinson and Company, Franklin Lakes, NJ, USA
Molly Jung
Affiliation:
Dept. of Medical Affairs, Becton Dickinson and Company, Franklin Lakes, NJ, USA
Samantha Bastow
Affiliation:
Dept. of Medical Affairs, Becton Dickinson and Company, Franklin Lakes, NJ, USA
*
Corresponding author: Kalvin C. Yu; Email: [email protected]
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Abstract

Objective:

This study quantified the burden of hospital-onset bacteremia and fungemia (HOB) among cancer and transplant patients compared to other patients.

Methods:

A retrospective cross-sectional study used data from 41 hospitals between October 2015 and June 2019. Hospitalizations were segmented into categories using diagnosis-related groups (DRG): myeloproliferative (MP) cancer, solid tumor cancer, transplant, and non-cancer/non-transplant (“reference group”). To quantify the association between DRG and HOB, multivariable adjusted Poisson regression models were fit. Analyses were stratified by length of stay (LOS).

Results:

Of 645,315 patients, 59% were female and the majority 41 years of age or older (76%). Hospitalizations with MP cancer and transplant demonstrated higher HOB burden compared to the reference group, regardless of LOS category. For all hospitalizations, the >30 days LOS category had a higher burden of HOB. The median time to reportable HOB was within 30 days regardless of duration of hospitalization (reference, 8 days; solid tumor cancer, 8 days; transplant, 12 days; MP cancer, 13 days).

Conclusion:

MP cancer and transplant patients had a higher burden of HOB compared to other hospitalized patients regardless of LOS. Whether these infections are preventable should be further evaluated to inform quality metrics involving reportable bacteremia and fungemia.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 45 , Issue 12 , December 2024 , pp. 1391 - 1398
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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