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Application of avian cytokines as immuno-modulating agents

Published online by Cambridge University Press:  02 December 2015

S. UMAR ,
M. ARIF ,
M.A.A. SHAH ,
M.T. MUNIR ,
M. YAQOOB ,
S. AHMED ,
M.I. KHAN ,
M. YOUNUS  and
M. SHAHZAD
S. UMAR*
Affiliation:
Faculty of Veterinary & Animal Science, PMAS Arid Agriculture University Rawalpindi, Pakistan National Veterinary School (ENVT), Toulouse, France
M. ARIF
Affiliation:
Faculty of Veterinary & Animal Science, PMAS Arid Agriculture University Rawalpindi, Pakistan
M.A.A. SHAH
Affiliation:
Faculty of Veterinary & Animal Science, PMAS Arid Agriculture University Rawalpindi, Pakistan
M.T. MUNIR
Affiliation:
Faculty of Veterinary & Animal Science, PMAS Arid Agriculture University Rawalpindi, Pakistan
M. YAQOOB
Affiliation:
Faculty of Veterinary & Animal Science, PMAS Arid Agriculture University Rawalpindi, Pakistan
S. AHMED
Affiliation:
Department of Animal Nutrition, University of Veterinary and Animal Sciences Lahore, Pakistan
M.I. KHAN
Affiliation:
Department of Animal Nutrition, University of Veterinary and Animal Sciences Lahore, Pakistan
M. YOUNUS
Affiliation:
Department of Pathology, University of Veterinary and Animal Sciences Lahore, Pakistan
M. SHAHZAD
Affiliation:
Department of Pathology, University of Veterinary and Animal Sciences Lahore, Pakistan
*
Corresponding author: [email protected]
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Abstract

The restricted use of antibiotics in the poultry sector has greatly enhanced the search for environment-friendly alternatives and complementary therapeutic approaches to manage infectious diseases in poultry. Cytokines, as natural immune-modulators, offer alternatives to conventional chemical-based therapeutics. Cytokine usage is becoming more feasible in poultry due to recent advancements in the field of immunology and vaccination, leading to the identification and cloning of avian cytokine genes. Existing adjuvants for poultry vaccines can have deleterious side-effects on the health and products of poultry and a subsequent reduction in profits. Therefore, alternative adjuvants must be developed to enhance the impact of vaccination. The use of cloned cytokines as adjuvants in poultry is attracting attention after the identification of new cytokine genes in chicken. Hence, cytokines may be used as therapeutics and vaccine adjuvants for enhancing immune response during infection and vaccination. This review focuses on the recent advancements in the application of avian cytokines as therapeutics or vaccine adjuvants.

Keywords

aviancytokinesimmuno-modulationtherapeuticadjuvants
Type
Reviews
Information
World's Poultry Science Journal , Volume 71 , Issue 4 , December 2015 , pp. 643 - 654
Copyright
Copyright © World's Poultry Science Association 2015 

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References

ABDELWHAB, E.M. and HAFEZ, M. (2012) Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1. Viruses 4: 3179-3208.CrossRefGoogle ScholarPubMed
ASIF, M., JENKINS, K.A., HILTON, L.S., KIMPTON, W.G., BEAN, A.G.D. and LOWENTHAL, J.W. (2004) Cytokines as adjuvants for avian vaccines. Immunology and Cell Biology 82: 638-643.CrossRefGoogle ScholarPubMed
CURTIS, M.M. and WAY, S.S. (2009) Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 126: 177-185.CrossRefGoogle ScholarPubMed
DE BOEVER, S., CROUBELS, S., DEMEYERE, K., LAMBRECHT, B., DE BACKER, P. and MEYER, E. (2010) Flow cytometric differentiation of avian leukocytes and analysis of their intracellular cytokine expression. Avian Pathology 39: 41-46.CrossRefGoogle ScholarPubMed
DIAZ-SAN SEGUNDO, F., WEISS, M., PEREZ-MARTIN, E., KOSTER, M.J., ZHU, J., GRUBMAN, M.J. and DE LOS SANTOS, T. (2011) Antiviral activity of bovine type III interferon against foot-and-mouth disease virus. Virology 413: 283-292.CrossRefGoogle ScholarPubMed
DIGBY, M.R. and LOWENTHAL, J.W. (1995) Cloning and expression of the chicken interferon-γ gene. Journal of Interferon Cytokine Research 15: 939-945.CrossRefGoogle ScholarPubMed
DJERABA, A., MUSSET, E. and LOWENTHAL, J.W. (2002) Protective effect of avian myelomonocytic growth factor in infection with Marek's disease virus. Journal of Virology 76: 1062-1070.CrossRefGoogle ScholarPubMed
DOWNING, T., LLOYD, A.T., O'FARRELLY, C. and BRADLEY, D.G. (2010) The Differential Evolutionary Dynamics of Avian Cytokine and TLR Gene Classes. The Journal of Immunology 184: 6993-7000.CrossRefGoogle ScholarPubMed
FRINGUELLI, E., URBANELLI, L., THARUNI, O., PROIETTI, P.C., BIETTA, A., DAVIDSON, I. and FRANCIOSINI, M.P. (2010) Cloning and expression of pigeon IFN-γ gene. Research in veterinary Sciences 89: 367-372.CrossRefGoogle ScholarPubMed
GOODMAN, A.G., ZENG, H., PROLL, S.C., PENG, X., CILLONIZ, C., CARTER, V.S., KORTH, M.J., TUMPEY, T.M. and KATZE, M.G. (2010) The α/β interferon receptor provides protection against influenza virus replication but is dispensable for inflammatory response signaling. Journal of Virology 84: 2027-2037.CrossRefGoogle ScholarPubMed
HAN, X., CHEN, T. and WANG, M. (2008) Molecular cloning and characterisation of chicken interferon-γ receptor α-chain. Journal of Interferon Cytokine Research 28: 445-454.CrossRefGoogle ScholarPubMed
HAN, C.L., ZHANG, W., DONG, H.T., HAN, X. and WANG, M. (2006) A novel gene of β chain of the IFN-γ receptor of Huiyang chicken: Cloning, distribution, and CD assay. Journal of Interferon Cytokine Research 26: 441-448.CrossRefGoogle ScholarPubMed
HAQ, K., WOOTTON, S.K., BARJESTEH, N., ST PAUL, M., GOLOVAN, S., BENDALL, A.J. and SHARIF, S. (2013) Small interfering RNA-mediated knockdown of chicken interferon-γ expression. J. Interferon Cytokine Research 33: 319-327.CrossRefGoogle ScholarPubMed
HILLIER, L.W., MILLER, W., BIRNEY, E., WARREN, W., HARDISON, R.C., PONTING, C.P., BORK, P., BURT, D.W. and GROENEN, M.A.M. (2004) Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature 432: 695-716.Google Scholar
HILTON, L.S.BEAN, A.G.D. and LOWENTHAL, J.W. (2002) The emerging role of cytokines as immunotherapeutic and adjuvants in vaccine. Veterinary Immunology and Immunopathology 85: 119-128.CrossRefGoogle ScholarPubMed
IVASHKIV, L.B. and DONLIN, L.T. (2014) Regulation of type I interferon responses. Nature review immunology 14: 36-49.CrossRefGoogle ScholarPubMed
KAISER, P., ROTHWELL, L., VASICEK, D. and HALA, K. (2002) A role for IL-15 in driving thr onset of spontaneous autoimmune thyroiditis? Journal of Immunology 168: 4216-4220.CrossRefGoogle Scholar
KALAIYARASU, S., KUMAR, D.S., KUMAR, M., SANKAR, P., ELAMURUGAN, A. and KARIKALAN, M. (2013) Cytokines as potent therapeutic agent and vaccine adjuvant in poultry. Research News for U (RNFU) 10: 2250-3668.Google Scholar
KARACA, K., SHARMA, J.M. and WINSLOW, B.J. (1998) Recombinant fowlpox viruses coexpressing chicken type I IFN and Newcastle disease virus HN and F genes: influence of IFN on protective efficacy and humoral responses of chickens following in ovo or post-hatch administration of recombinant viruses. Vaccine 16: 1496-1503.CrossRefGoogle ScholarPubMed
KARPALA, A.J., BAGNAUD-BAULE, A., GOOSSENS, K.E., LOWENTHAL, J.W. and BEAN, A.G. (2012a) Ontogeny of the interferon system in chickens. Journal of reproduction and immunology 94: 169-174.CrossRefGoogle ScholarPubMed
KARPALA, A.J., LOWENTHAL, J.W. and BEAN, A.G. (2012b) Identifying innate immune pathways of the chicken may lead to new antiviral therapies. Veterinary Immunology and Immunopathology 148:100-109.CrossRefGoogle ScholarPubMed
KARPALA, A.J., MORRIS, K.R., BROADWAY, M.M., MCWATERS, P.G., ONEIL, T.E., GOOSSENS, K.E., LOWENTHAL, J.W. and BEAN, A.G. (2008) Molecular cloning, expression, and characterisation of chicken IFN-λ. Journal of Interferon Cytokine Research 28: 341-350.CrossRefGoogle ScholarPubMed
LAWSON, S., ROTHWELL, L., LAMBRECHT, B., HOWES, K., VENUGOPAL, K. and KAISER, P. (2001) Turkey and chicken interferon-γ, which share high sequence identity, are biologically cross-reactive. Developmental and Comparative Immunology 25: 69-82.CrossRefGoogle ScholarPubMed
LI, H.T., MA, B., MI, J.W., JIN, H.Y., XU, L.N. and WANG, J.W. (2007) Molecular cloning and functional analysis of goose interferon gamma. Veterinary Immunology and Immunopathology 117: 67-74.CrossRefGoogle ScholarPubMed
LI, H.T., MA, B., MI, J.W., JIN, H.Y., XU, L.N. and WANG, J.W. (2006) Cloning, in vitro expression and bioactivity of goose interferon-α. Cytokine 34: 177-183.CrossRefGoogle ScholarPubMed
LOWENTHAL, J.W., LAMBRECHT, B., VAN DEN BERG, T.P., ANDREW, M.E., STROM, A.D.G. and BEAN, A.G.D. (2000) Avian cytokines D the natural approach to therapeutics. Developmental and Comparative Immunology 24: 355-365.CrossRefGoogle Scholar
MARCUS, P.I, VAN DER HEIDE, L. and SEKELLICK, M.J. (1999) Interferon action on avian viruses: Oral administration of chicken interferon-α ameliorates Newcastle disease. Journal of Interferon Cytokine Research 19: 881-885.CrossRefGoogle ScholarPubMed
MENG, S., YANG, L., XU, C., QIN, Z., XU, H., WANG, Y., SUN, L. and LIU, W. (2011) Recombinant chicken interferon-α inhibits H9N2 avian influenza virus replication in vivo by oral administration. Journal of Interferon Cytokine Research 31: 533-538.CrossRefGoogle ScholarPubMed
QU, H., YANG, L., MENG, S., XU, L., BI, Y., JIA, X., LI, J., SUN, L. and LIU, W. (2013) The differential antiviral activities of chicken interferon α (ChIFN-α) and ChIFN-β are related to distinct interferon-stimulated gene expression. PLoS One 8: e59307.CrossRefGoogle ScholarPubMed
RAUTENSCHLEIN, S., SHARMA, J.M., WINSLOW, B.J., MCMILLEN, J., JUNKER, D. and COCHRAN, M. (2000) Embryo vaccination of turkeys against Newcastle disease infection with recombinant fowl pox virus constructs containing interferons as adjuvants. Vaccine 18: 426-433.CrossRefGoogle Scholar
REBOUL, J., GARDINER, K., MONNERON, D., UZÉ, G. and LUTFALLA, G. (1999) Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. Genome Research 9: 242-250.CrossRefGoogle ScholarPubMed
REDMOND, S.B., CHUAMMITRI, P., ANDREASEN, C.B., PALIC, D. and LAMONT, S.J. (2009) Chicken heterophils from commercially selected and non-selected genetic lines express cytokines differently after in vitro exposure to Salmonella enteritidis. Veterinary Immunology and Immunopathology 132: 129-134.CrossRefGoogle ScholarPubMed
REUTER, A., SOUBIES, S., HARTLE, S., SCHUSSER, B., KASPERS, B., STAEHELI, P. and RUBBENSTROTH, D. (2014) Antiviral activity of λ interferon in chickens. Journal of Virology 88: 2835-2843.CrossRefGoogle ScholarPubMed
SCHIJNS, V.E., WEINING, K.C., NUIJTEN, P., RIJKE, E.O. and STAEHELI, P. (2000) Immunoadjuvant activities of E. coli- and plasmid-expressed recombinant chicken IFN-alpha/beta, IFN-gamma and IL-1beta in 1-day- and 3-week-old chickens. Vaccine 18: 2147-2154.CrossRefGoogle ScholarPubMed
SCHNEIDER, K., KLAA, R., KASPERS, B. and STAEHELI, P. (2001) Chicken interleukin-6 cDNA structure and biological properties. European Journal of Biochemistry 268: 4200-4206.CrossRefGoogle ScholarPubMed
SCHOGGINS, J.W., WILSON, S.J., PANIS, M., MURPHY, M.Y., JONES, C.T., BIENIASZ, P. and RICE, C.M. (2011) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472: 481-485.CrossRefGoogle ScholarPubMed
SMITH, S.E. GIBSON, M.S. WASH, R.S., FERRARA, F., WRIGHT, E., TEMPERTON, N., KELLAM, P. and FIFE, M. (2013) Chicken interferon-inducible transmembrane protein 3 restricts influenza viruses and lyssaviruses in vitro. Journal of Virology 87: 12957-12966.CrossRefGoogle ScholarPubMed
SUSTA, L., CORNAX, I., DIEL, D.G., GARCIA, S.C., MILLER, P.J., LIU, X., HU, S., BROWN, C.C. and AFONSO, C.L. (2013) Expression of interferon γ by a highly virulent strain of Newcastle disease virus decreases its pathogenicity in chickens. Microbial pathogenesis 61: 73-83.CrossRefGoogle ScholarPubMed
WEINING, K.C., SICK, C., KASPERS, B. and STAEHELI, P. (1998) A chicken homologue of mammalian interleukin-1b: cDNA cloning and purification of active recombinant protein. European Journal of Biochemistry 258: 994-1000.CrossRefGoogle Scholar
WIGLEY, P. and KAISER, P. (2003) Avian Cytokines in Health and Disease. Brazilian Journal of Poultry Science 5: 1-14.CrossRefGoogle Scholar
WILSON, E.B. and BROOKS, D.G. (2013) Interfering with type I interferon: A novel approach to purge persistent viral infection. Cell Cycle 12: 2919-2920.CrossRefGoogle ScholarPubMed
XU, L., YANG, L. and LIU, W. (2013) Distinct evolution process among type I interferon in mammals. Protein Cell 4: 383-392.CrossRefGoogle ScholarPubMed
YANG, L., XU, L., LI, Y., LI, J., BI, Y. and LIU, W. (2013) Molecular and functional characterisation of canine interferon-ε. Journal of. Interferon Cytokine Research 33: 760-768.CrossRefGoogle ScholarPubMed
YAO, Q., FISCHER, K.P., ARNESEN, K., TYRRELL, D.L. and GUTFREUND, K.S. (2014) Molecular cloning, expression and characterisation of Pekin duck interferon-λ. Gene 548: 29-38.CrossRefGoogle ScholarPubMed
ZHOU, H., CHEN, S., WANG, M. and CHENG, A. (2014) Interferons and Their Receptors in Birds: A Comparison of Gene Structure, Phylogenetic Analysis, and Cross Modulation. International journal of molecular science 15: 21045-21068.CrossRefGoogle ScholarPubMed