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The relationship between cognitive impairment in schizophrenia and metabolic syndrome: a systematic review and meta-analysis

Published online by Cambridge University Press:  29 December 2016

E. Bora ,
B. B. Akdede  and
K. Alptekin
E. Bora*
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia Department of Psychiatry, Dokuz Eylul University School of Medicine, Izmir, Turkey
B. B. Akdede
Affiliation:
Department of Psychiatry, Dokuz Eylul University School of Medicine, Izmir, Turkey
K. Alptekin
Affiliation:
Department of Psychiatry, Dokuz Eylul University School of Medicine, Izmir, Turkey
*
*Address for correspondence: Dr E. Bora, Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Alan Gilbert Building NNF level 3, Carlton 3053, Australia. (Email: [email protected]; [email protected])
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Abstract

Background

Individuals with schizophrenia are at greater risk for metabolic syndrome (MetS) which is associated with cognitive deficits in the general population. MetS might be potentially an important contributing factor to cognitive impairment in schizophrenia.

Method

In the current systematic review and meta-analysis, the findings of 18 studies investigating the association between MetS (and its components) with cognitive impairment in schizophrenia are reviewed.

Results

Co-morbidity of MetS (d = 0.28) and diabetes mellitus (d = 0.28) were both associated with more severe cognitive deficits in schizophrenia. There was also evidence for a significant relationship between cognitive impairment in schizophrenia and each of the components of MetS including hypertension, dyslipidemia, abdominal obesity and diabetes.

Conclusions

MetS is significantly associated with cognitive impairment in schizophrenia and can potentially contribute to functional decline observed in some patients with schizophrenia throughout the course of illness.

Keywords

Cognitiondiabetes mellitusdyslipidemiahypertensionmetabolic syndromeobesityschizophrenia
Type
Review Article
Information
Psychological Medicine , Volume 47 , Issue 6 , April 2017 , pp. 1030 - 1040
Copyright
Copyright © Cambridge University Press 2016 

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