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The role of L-carnitine in the control of oxidative stress and lipid β-oxidation during in vitro follicle growth, oocyte maturation, embryonic development and cryopreservation: a review

Published online by Cambridge University Press:  07 November 2024

Allana Maria Freire Leitão Open the ORCID record for Allana Maria Freire Leitão [Opens in a new window] ,
Bianca Regia Silva ,
Efigênia C. Barbalho ,
Lais R.M. Paulino ,
Francisco das Chagas Costa Open the ORCID record for Francisco das Chagas Costa [Opens in a new window] ,
Fabricio Sousa Martins  and
Jose Roberto V. Silva Open the ORCID record for Jose Roberto V. Silva [Opens in a new window]
Allana Maria Freire Leitão
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceara, Av. Comandante Maurocélio Rocha Ponte 100, postal code 62041-040, Sobral, CE, Brazil
Bianca Regia Silva
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceara, Av. Comandante Maurocélio Rocha Ponte 100, postal code 62041-040, Sobral, CE, Brazil
Efigênia C. Barbalho
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceara, Av. Comandante Maurocélio Rocha Ponte 100, postal code 62041-040, Sobral, CE, Brazil
Lais R.M. Paulino
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceara, Av. Comandante Maurocélio Rocha Ponte 100, postal code 62041-040, Sobral, CE, Brazil
Francisco das Chagas Costa
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceara, Av. Comandante Maurocélio Rocha Ponte 100, postal code 62041-040, Sobral, CE, Brazil
Fabricio Sousa Martins
Affiliation:
State University of Acaraú Valley, Center of Agricultural and Biological Sciences, postal code 62040370, Sobral, CE, Brazil
Jose Roberto V. Silva*
Affiliation:
Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceara, Av. Comandante Maurocélio Rocha Ponte 100, postal code 62041-040, Sobral, CE, Brazil
*
Corresponding author: Jose Roberto V. Silva; Email: [email protected]
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Abstract

L-carnitine has an important role in the control of oxidative stress and lipid β-oxidation during in vitro culture and cryopreservation of ovarian follicles, oocytes and embryos. This substance balances the acetyl-CoA/CoA ratio, maintains glucose metabolism and increases energy production in mitochondria. It also plays a key role in reducing endoplasmic reticulum stress, by transferring palmitate to mitochondria or eliminating it to avoid toxicity. By eliminating reactive oxygen species, L-carnitine increases the percentages of mature oocytes with uniform mitochondrial distribution and improves embryo post-thaw cryotolerance. Therefore, L-carnitine controls lipid β-oxidation and oxidative stress during in vitro culture of ovarian follicles, oocyte maturation, embryonic development and cryopreservation.

Keywords

cryopreservationembryoin vitro cultureL-carnitineoocyte
Type
Review Article
Information
Zygote , Volume 32 , Issue 5 , October 2024 , pp. 335 - 340
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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