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Monoamniotic twin pregnancy following the transfer of a single blastocyst resulting from intracytoplasmic sperm injection of a single oocyte: a case report

Published online by Cambridge University Press:  16 April 2020

Romualdo Sciorio Open the ORCID record for Romualdo Sciorio [Opens in a new window] ,
Sandro C. Esteves ,
Motaz Alahmad ,
Elisavet Angelaki  and
Naser Al-Azemi
Romualdo Sciorio*
Affiliation:
Edinburgh Assisted Conception Programme, EFREC, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, Scotland, EH16 4SA, UK Reproductive Medicine & IVF Unit, Royale Hayat Hospital, Kuwait City, Kuwait
Sandro C. Esteves
Affiliation:
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil Department of Surgery (Division of Urology), University of Campinas (UNICAMP), Campinas, Brazil Faculty of Health, Aarhus University, Aarhus, Denmark Reproductive Medicine & IVF Unit, Royale Hayat Hospital, Kuwait City, Kuwait
Motaz Alahmad
Affiliation:
Reproductive Medicine & IVF Unit, Royale Hayat Hospital, Kuwait City, Kuwait
Elisavet Angelaki
Affiliation:
Reproductive Medicine & IVF Unit, Royale Hayat Hospital, Kuwait City, Kuwait
Naser Al-Azemi
Affiliation:
Reproductive Medicine & IVF Unit, Royale Hayat Hospital, Kuwait City, Kuwait
*
Author for correspondence: Romualdo Sciorio. Edinburgh Assisted Conception Programme, EFREC, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, Scotland, EH16 4SA, UK. E-mail: [email protected]
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Summary

In this report we present an unusual case of a couple who achieved a twin pregnancy by intracytoplasmic sperm injection (ICSI) with a single immature oocyte retrieved. The oocyte was at metaphase I at 39 h post human chorionic gonadotrophin (hCG) administration, which is our standard ICSI time. Extended culture allowed the extrusion of the polar body, and sperm injection was performed at 43 h post-trigger. The fertilized egg underwent embryo biopsy on day 3 and preimplantation genetic assessment for three chromosomes (X, Y and 21). The embryo remained in culture until day 5. Later, the biopsy results reported a transferable embryo, which was replaced to the uterine cavity at blastocyst stage. Pregnancy test gave a positive β-hCG result, and the 6 weeks’ scan, performed to confirm the fetal heart, revealed the presence of one amniotic sac and two fetal heartbeats, which currently have been so far eventless and smooth, ongoing at 18 weeks of gestation.

Keywords

Embryo biopsyFertilizationICSI timeIn vitro fertilization (IVF)Multiple gestationOngoing pregnancyOocyte maturation
Type
Short Communication
Information
Zygote , Volume 28 , Issue 4 , August 2020 , pp. 344 - 348
Copyright
© Cambridge University Press 2020

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