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Meiotic cycle checkpoints in mammalian oocytes

Published online by Cambridge University Press:  26 September 2008

Josef Fulka Jr ,
Judy Bradshaw  and
Robert Moor
Josef Fulka Jr
Affiliation:
Deparment of Development and Singnalling, The Babraham Institute, Cambridge, CB2 4AT, UK
Judy Bradshaw
Affiliation:
Deparment of Development and Singnalling, The Babraham Institute, Cambridge, CB2 4AT, UK
Robert Moor
Affiliation:
Deparment of Development and Singnalling, The Babraham Institute, Cambridge, CB2 4AT, UK
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Extract

Recent Spectacular achievements have enabled the identification of key molecules responsible for mitotic cell cycle progression through the stages of G1, the gap before DNA replication; S, the phase of DNA synthesis; G2, the gap before chromosome segregation; and M, mitosis itself. The last stage has been most intensively studied, where MPE, maturation promotion factor, has been found responsible for the nuclear events associated with chromosomal segregation and the prodcution of two identical daughter cells (see Murray & Hunt, 1993).

Type
Article
Information
Zygote , Volume 2 , Issue 4 , November 1994 , pp. 351 - 354
Copyright
Copyright © Cambridge University Press 1994

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References

Briggs, R., Green, E.U., & King, T.J. (1951). An investigation of the capacity ofr cleavage differentiation in Rama Pipiens eggs lacking functional chromosomes. J. Exp. Zool. 116, 455–99.CrossRefGoogle Scholar
Canipari, R., Palombi, F., Riminucci, M. & Mangia, F. (1984). Early programming of maturation competence in mouse oogenesis Dev. Biol. 102, 519–24.CrossRefGoogle ScholarPubMed
Christmann, L., Jung, T., & Moor, R.M., (1994). MPF components and meiotic competence in growing pig oocytes. Mol. Reprod. Dev. 38, 85–90.CrossRefGoogle ScholarPubMed
Enoch, T., & Nurse, P., (1991). Coupling M-phase and S-phase: controls maintatining the dependence of mitosis on chromosome replication. Cell. 65, 921–3.CrossRefGoogle Scholar
Fulka, J. Jr, Moor, R.M., & Fulka, J. (1994). Sister chromatid separation and the metaphase-anaphase transition on mouse oocytes. Dev. Biol. (in press).CrossRefGoogle ScholarPubMed
Gurdon, J.B., (1960). The effects of UV irradiation on uncleaved eggs of Xenopus laevis. Q. J. Microsc. Sci. 101, 299–311.Google Scholar
Hartwell, L.H. & Weinert, T.A., (1989). Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629–34.CrossRefGoogle ScholarPubMed
Hoyt, M.A., Totis, L. & Roberts, B.T. (1991). S. Cerevisae genses required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507–17.CrossRefGoogle Scholar
Hunter, T.. (1993). Braking the cycle. Cell. 75, 839–41.CrossRefGoogle ScholarPubMed
Johnson, R.T., & Rao, P.N., (1970). Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis. Nature 225, 159–64.Google Scholar
Kimelman, T., Kirschner, M., & Scherson, T.. (1987). The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle. Cell. 48, 399–407.CrossRefGoogle ScholarPubMed
Li, R. & Murray, A.W. (1991). Feedback control of mitosis in budding yeast. Cell 66, 519–31.CrossRefGoogle ScholarPubMed
Masui, Y.. & Pedersen, R.A.. (1975). Ultraviolet light induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation. Nature 257, 705–6.CrossRefGoogle ScholarPubMed
Murray, A.W., (1992). Creative blocks: cell cycle checkpoints and feedback controls. Nautre 359, 599–604.CrossRefGoogle ScholarPubMed
Murray, A.W. & Hunt, T.. (1993). The Cell cycle: An Introduction. W.H.Freeman, New York.Google Scholar
Murray, A.W., & Kirschner, M.W.. (1989). Dominoes and clocks: the union of two views of the cell cycle. Science 246, 614–21.CrossRefGoogle ScholarPubMed
Ouhibi, N., Fulka, J., Kanka, J. & Moor, R.M. (1994). A reversible block at the G1/S border during the cell cycle progression of mouse emryose. J. Reprod. Fert. 13, 24.Google Scholar
Sheldrick, K.S., & Carr, A.M.. (1993). Feedback controls and G2 checkpoints: fission yeast as a model system. Bioessays 15, 775–82.CrossRefGoogle ScholarPubMed