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Growth factor receptor-bound protein 14: a potential new gene associated with oocyte competence

Published online by Cambridge University Press:  17 May 2013

Paulo Roberto Antunes Rosa ,
Rodrigo Camponogara Bohrer ,
Matheus Pedrotti De Cesaro ,
Karina Gutierrez ,
Rogério Ferreira ,
Gabriel Ribas Pereira ,
João Francisco Coelho Oliveira  and
Paulo Bayard Dias Gonçalves
Paulo Roberto Antunes Rosa
Affiliation:
Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria, Santa Maria, RS 97105–900, Brazil.
Rodrigo Camponogara Bohrer
Affiliation:
Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria, Santa Maria, RS 97105–900, Brazil.
Matheus Pedrotti De Cesaro
Affiliation:
Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria, Santa Maria, RS 97105–900, Brazil.
Karina Gutierrez
Affiliation:
Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria, Santa Maria, RS 97105–900, Brazil.
Rogério Ferreira
Affiliation:
Department of Animal Science, Santa Catarina State University, Chapecó, SC, 89802–200, Brazil.
Gabriel Ribas Pereira
Affiliation:
Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria, Santa Maria, RS 97105–900, Brazil.
João Francisco Coelho Oliveira
Affiliation:
Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria, Santa Maria, RS 97105–900, Brazil.
Paulo Bayard Dias Gonçalves*
Affiliation:
Laboratory of Biotechnology and Animal Reproduction- BioRep, Federal University of Santa Maria, Av. Roraima #1000, CEP 97105–900, Santa Maria, RS 97105–900, Brazil. Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria, Santa Maria, RS 97105–900, Brazil.
*
All correspondence to: Paulo Bayard Dias Gonçalves. Laboratory of Biotechnology and Animal Reproduction- BioRep, Federal University of Santa Maria, Av. Roraima #1000, CEP 97105–900, Santa Maria, RS 97105–900, Brazil. Tel: +55 55 3220 8752. Fax: +55 55 3220 8484. E-mail: [email protected]
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Summary

The Grb14 protein is a member of the Grb7 protein family. This protein family acts by binding to tyrosine kinase receptors, promoting cell proliferation and differentiation. There is evidence of the involvement of tyrosine kinase factors in the bovine oocyte maturation process. However, Grb14 has not been studied for bovine cumulus–oocyte complexes (COCs). The aim of the present study was to characterize Grb14 mRNA expression in bovine COCs during follicular development. Furthermore, we demonstrated that the expression of Grb14 mRNA is not regulated by estradiol. mRNA expression of Grb14 was assessed in 480 COCs from follicles of different sizes (1–3, 4–6, 6–8 or >8 mm) by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Grb14 mRNA expression decreased in COCs throughout follicular growth (P < 0.05). The role of estradiol in the expression of Grb14 mRNA in COCs was studied. Grb14 mRNA abundance did not differ in COCs cultured in the presence or absence of 17β-estradiol or fulvestrant. In conclusion, we showed that Grb14 mRNA is downregulated in COCs during antral follicle development, a finding that suggests a role for Grb14 in oocyte competence.

Keywords

CattleFollicle developmentGrb14OocyteOocyte maturation
Type
Research Article
Information
Zygote , Volume 22 , Issue 2 , May 2014 , pp. 103 - 109
Copyright
Copyright © Cambridge University Press 2013 

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