Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-22T18:48:22.826Z Has data issue: false hasContentIssue false
  • English
  • Français

Gonadotrophin-releasing hormone agonist triggering may improve central oocyte granularity and embryo quality

Published online by Cambridge University Press:  03 April 2020

Kuo-Chung Lan Open the ORCID record for Kuo-Chung Lan [Opens in a new window] ,
Yu-Chen Chen ,
Yi-Chi Lin  and
Yi-Ru Tsai
Kuo-Chung Lan*
Affiliation:
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Center for Menopause and Reproductive Medicine Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Yu-Chen Chen
Affiliation:
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Yi-Chi Lin
Affiliation:
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Yi-Ru Tsai
Affiliation:
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
*
Author for correspondence: Kuo-Chung Lan, Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung City, Taiwan. Tel: +886 7 7317123 ext. 8916; Fax: +886 7 7322915. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Summary

This study aimed to describe outcomes in four women aged 28–34 years with central cytoplasmic granulation (CCG) of the oocytes who underwent in vitro fertilization/intracytoplasmic sperm injection (ICSI) using gonadotrophin-releasing hormone (GnRH) agonist to replace human chorionic gonadotrophin (hCG) as a trigger of final oocyte maturation. The initial ICSI procedure showed that all four women had CCG of the ooplasm and poor quality embryos. Subsequent ICSI used an antagonist protocol with a GnRH agonist trigger replacing the agonist protocol, plus hCG triggered ovulation. Ooplasm and embryo quality were improved in all four patients. All four became pregnant and gave birth to live infants. This study provides GnRH agonist triggering that may improve ooplasm granularity and embryo quality.

Keywords

Centrally cytoplasmic granulationEmbryo qualityGnRH agonist triggerHuman chorionic gonadotrophin triggerICSI
Type
Short Communication
Information
Zygote , Volume 28 , Issue 4 , August 2020 , pp. 337 - 343
Copyright
© Cambridge University Press 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

These authors contributed equally to this work.

References

Al-Inany, HG, Youssef, MA, Ayeleke, RO, Brown, J, Lam, WS and Broekmans, FJ (2016) Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev 4, CD001750.Google ScholarPubMed
Balaban, B and Urman, B (2006) Effect of oocyte morphology on embryo development and implantation. Reprod Biomed Online 12, 608–15.CrossRefGoogle ScholarPubMed
Balaban, B, Ata, B, Isiklar, A, Yakin, K and Urman, B (2008) Severe cytoplasmic abnormalities of the oocyte decrease cryosurvival and subsequent embryonic development of cryopreserved embryos. Hum Reprod 23, 1778–85.CrossRefGoogle ScholarPubMed
Brus, L, Lambalk, CB, de Koning, J, Helder, MN, Janssens, RM and Schoemaker, J (1997) Specific gonadotrophin-releasing hormone analogue binding predominantly in human luteinized follicular aspirates and not in human pre-ovulatory follicles. Hum Reprod 12, 769–73.CrossRefGoogle ScholarPubMed
Casper, RF (2015) Basic understanding of gonadotropin-releasing hormone-agonist triggering. Fertil Steril 103, 867–9.CrossRefGoogle ScholarPubMed
Cheung, LW and Wong, AS (2008) Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues. FEBS J 275, 5479–95.CrossRefGoogle ScholarPubMed
Cota, AM, Oliveira, JB, Petersen, CG, Mauri, AL, Massaro, FC, Silva, LF, Nicoletti, A, Cavagna, M, Baruffi, RL and Franco, JG Jr (2012) GnRH agonist versus GnRH antagonist in assisted reproduction cycles: oocyte morphology. Reprod Biol Endocrinol 10, 33.CrossRefGoogle ScholarPubMed
Dosouto, C, Haahr, T and Humaidan, P (2017) Gonadotropin-releasing hormone agonist (GnRHa) trigger – state of the art. Reprod Biol 17, 1–8.CrossRefGoogle ScholarPubMed
Engmann, L, Benadiva, C and Humaidan, P (2016) GnRH agonist trigger for the induction of oocyte maturation in GnRH antagonist IVF cycles: a SWOT analysis. Reprod Biomed Online 32, 274–85.CrossRefGoogle ScholarPubMed
Eppig, JJ (1979) FSH stimulates hyaluronic acid synthesis by oocyte–cumulus cell complexes from mouse preovulatory follicles. Nature 281, 483–4.CrossRefGoogle ScholarPubMed
Fancsovits, P, Tothne, ZG, Murber, A, Rigo, J Jr and Urbancsek, J (2012) Importance of cytoplasmic granularity of human oocytes in in vitro fertilization treatments. Acta Biol Hung 63, 189–201.CrossRefGoogle ScholarPubMed
Fauser, BC, de Jong, D, Olivennes, F, Wramsby, H, Tay, C, Itskovitz-Eldor, J and van Hooren, HG (2002) Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab 87, 709–15.CrossRefGoogle ScholarPubMed
Gilchrist, RB, Lane, M and Thompson, JG (2008) Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality. Hum Reprod Update 14, 159–77.CrossRefGoogle ScholarPubMed
Humaidan, P, Kol, S, Papanikolaou, EG and Copenhagen Gn, R. H. A. T. W. G (2011) GnRH agonist for triggering of final oocyte maturation: time for a change of practice? Hum Reprod Update 17, 510–24.CrossRefGoogle ScholarPubMed
Imoedemhe, DA, Sigue, AB, Pacpaco, EL and Olazo, AB (1991) Stimulation of endogenous surge of luteinizing hormone with gonadotropin-releasing hormone analog after ovarian stimulation for in vitro fertilization. Fertil Steril 55, 328–32.CrossRefGoogle ScholarPubMed
Kahraman, S, Yakin, K, Donmez, E, Samli, H, Bahce, M, Cengiz, G, Sertyel, S, Samli, M and Imirzalioglu, N (2000) Relationship between granular cytoplasm of oocytes and pregnancy outcome following intracytoplasmic sperm injection. Hum Reprod 15, 2390–3.CrossRefGoogle ScholarPubMed
Kahraman, S, Benkhalifa, M, Donmez, E, Biricik, A, Sertyel, S, Findikli, N and Berkil, H (2004) The results of aneuploidy screening in 276 couples undergoing assisted reproductive techniques. Prenat Diagn 24, 307–11.CrossRefGoogle ScholarPubMed
Kidder, GM and Vanderhyden, BC (2010) Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence. Can J Physiol Pharmacol 88, 399–413.CrossRefGoogle ScholarPubMed
Lan, KC, Huang, FJ, Lin, YC, Kung, FT, Hsieh, CH, Huang, HW, Tan, PH and Chang, SY (2003) The predictive value of using a combined Z-score and day 3 embryo morphology score in the assessment of embryo survival on day 5. Hum Reprod 18, 1299–306.CrossRefGoogle ScholarPubMed
Lan, KC, Lin, YC, Chang, YC, Lin, HJ, Tsai, YR and Kang, HY (2019) Limited relationships between reactive oxygen species levels in culture media and zygote and embryo development. J Assist Reprod Genet 36, 325–34.CrossRefGoogle ScholarPubMed
Matzuk, MM, Burns, KH, Viveiros, MM and Eppig, JJ (2002) Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science 296, 2178–80.CrossRefGoogle ScholarPubMed
Merviel, P, Cabry, R, Chardon, K, Haraux, E, Scheffler, F, Mansouri, NB, Devaux, A, Chahine, H, Bach, V, Copin, H and Benkhalifa, M (2017) Impact of oocytes with CLCG on ICSI outcomes and their potential relation to pesticide exposure. J Ovarian Res 10, 42.CrossRefGoogle ScholarPubMed
Murber, A, Fancsovits, P, Ledo, N, Gilan, ZT, Rigo, J Jr and Urbancsek, J (2009) Impact of GnRH analogues on oocyte/embryo quality and embryo development in in vitro fertilization/intracytoplasmic sperm injection cycles: a case control study. Reprod Biol Endocrinol 7, 103.CrossRefGoogle ScholarPubMed
Otsuki, J, Okada, A, Morimoto, K, Nagai, Y and Kubo, H (2004) The relationship between pregnancy outcome and smooth endoplasmic reticulum clusters in MII human oocytes. Hum Reprod 19, 1591–7.CrossRefGoogle ScholarPubMed
Pacchiarotti, A, Selman, H, Valeri, C, Napoletano, S, Sbracia, M, Antonini, G, Biagiotti, G and Pacchiarotti, A (2016) Ovarian stimulation protocol in IVF: an up-to-date review of the literature. Curr Pharm Biotechnol 17, 303–315.CrossRefGoogle ScholarPubMed
Plachot, M (2001) Chromosomal abnormalities in oocytes. Mol Cell Endocrinol 183 Suppl 1, S59–63.CrossRefGoogle ScholarPubMed
Reh, A, Krey, L and Noyes, N (2010) Are gonadotropin-releasing hormone agonists losing popularity? Current trends at a large fertility center. Fertil Steril 93, 101–8.CrossRefGoogle Scholar
Rienzi, L, Ubaldi, FM, Iacobelli, M, Minasi, MG, Romano, S, Ferrero, S, Sapienza, F, Baroni, E, Litwicka, K and Greco, E (2008) Significance of metaphase II human oocyte morphology on ICSI outcome. Fertil Steril 90, 1692–700.CrossRefGoogle ScholarPubMed
Rienzi, L, Balaban, B, Ebner, T and Mandelbaum, J (2012) The oocyte. Hum Reprod, 27 Suppl 1, i2–21.CrossRefGoogle ScholarPubMed
Serhal, PF, Ranieri, DM, Kinis, A, Marchant, S, Davies, M and Khadum, IM (1997) Oocyte morphology predicts outcome of intracytoplasmic sperm injection. Hum Reprod 12, 1267–70.CrossRefGoogle ScholarPubMed
Strickland, S and Beers, WH (1976) Studies on the role of plasminogen activator in ovulation. In vitro response of granulosa cells to gonadotropins, cyclic nucleotides, and prostaglandins. J Biol Chem 251, 5694–702.Google ScholarPubMed
Swain, JE (2012) Is there an optimal pH for culture media used in clinical IVF? Hum Reprod Update 18, 333–9.CrossRefGoogle ScholarPubMed
Van Blerkom, J (1990) Occurrence and developmental consequences of aberrant cellular organization in meiotically mature human oocytes after exogenous ovarian hyperstimulation. J Electron Microsc Tech 16, 324–46.CrossRefGoogle ScholarPubMed
Yding Andersen, C, Leonardsen, L, Ulloa-Aguirre, A, Barrios-De-Tomasi, J, Moore, L and Byskov, AG (1999) FSH-induced resumption of meiosis in mouse oocytes: effect of different isoforms. Mol Hum Reprod 5, 726–31.CrossRefGoogle ScholarPubMed
Zeleznik, AJ, Schuler, HM and Reichert, LE Jr (1981) Gonadotropin-binding sites in the rhesus monkey ovary: role of the vasculature in the selective distribution of human chorionic gonadotropin to the preovulatory follicle. Endocrinology 109, 356–62.CrossRefGoogle ScholarPubMed
Zelinski-Wooten, MB, Hutchison, JS, Hess, DL, Wolf, DP and Stouffer, RL (1995) Follicle stimulating hormone alone supports follicle growth and oocyte development in gonadotrophin-releasing hormone antagonist-treated monkeys. Hum Reprod 10, 1658–66.CrossRefGoogle ScholarPubMed