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Female fertility preservation strategies: cryopreservation and ovarian tissue in vitro culture, current state of the art and future perspectives

Published online by Cambridge University Press:  04 May 2016

M.A. Filatov ,
Y.V. Khramova ,
M.V. Kiseleva ,
I.V. Malinova ,
E.V. Komarova  and
M.L. Semenova
M.A. Filatov*
Affiliation:
Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1, bld. 12, Moscow 119991, Russia.
Y.V. Khramova
Affiliation:
Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1, bld. 12, Moscow 119991, Russia.
M.V. Kiseleva
Affiliation:
Medical Radiological Research Centre, Ministry of Health of the Russian Federation (MMRC), Koroleva st. 4, Obninsk 249036, Russia.
I.V. Malinova
Affiliation:
Medical Radiological Research Centre, Ministry of Health of the Russian Federation (MMRC), Koroleva st. 4, Obninsk 249036, Russia.
E.V. Komarova
Affiliation:
Medical Radiological Research Centre, Ministry of Health of the Russian Federation (MMRC), Koroleva st. 4, Obninsk 249036, Russia.
M.L. Semenova
Affiliation:
Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1, bld. 12, Moscow 119991, Russia.
*
All correspondence to: M.A. Filatov. Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1, bld. 12, Moscow 119991, Russia. Tel: +7 495 939 39 00. E-mail: [email protected]
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Summary

In the present review, the main strategies of female fertility preservation are covered. Procedures of fertility preservation are necessary for women who suffer from diseases whose treatment requires the use of aggressive therapies, such as chemotherapy and radiotherapy. These kinds of therapy negatively influence the health of gametes and their progenitors. The most commonly used method of female fertility preservation is ovarian tissue cryopreservation, followed by the retransplantation of thawed tissue. Another approach to female fertility preservation that has been actively developed lately is the ovarian tissue in vitro culture. The principal methods, advantages and drawbacks of these two strategies are discussed in this article.

Keywords

CryopreservationIn vitroOncologyOvaryTissue
Type
Research Article
Information
Zygote , Volume 24 , Issue 5 , October 2016 , pp. 635 - 653
Copyright
Copyright © Cambridge University Press 2016 

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