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Evaluation of the antifertility activity of the broom Spartium junceum in the mammalian male

Published online by Cambridge University Press:  26 September 2008

B. Baccetti ,
A.G. Burrini ,
J.S. Chen ,
G. Collodel ,
D. Giachetti ,
F. Matteucci ,
M.G. Menesini-Chen ,
E. Moretti ,
P. Piomboni  and
C. Sensini
B. Baccetti*
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
A.G. Burrini
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
J.S. Chen
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
G. Collodel
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
D. Giachetti
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
F. Matteucci
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
M.G. Menesini-Chen
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
E. Moretti
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
P. Piomboni
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
C. Sensini
Affiliation:
Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Siena, Italy
*
Professor Baccio Baccetti, Istituto Biologia Generale and Centro Studio Cellule Germinali, CNR, Via T. Pendola 62, 53100 Siena, Italy. Telephone: 0039 577 284173. Fax: 0039 577 44474.
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Summary

Male adult rabbits and rats treated with Spartium junceum showed a significant decrease in fertility, demonstrated by a lower number of pregnancies. The target of the drug seems to be the acrosomal protease system, the activity of which appears greatly reduced, while the morphology of testicular cells and epididymal spermatozoa is only partially affected. The antifertility effect is completely reversible.

Keywords

AcrosomeContraceptionRabbitRatSpartium junceum
Type
Article
Information
Zygote , Volume 1 , Issue 1 , February 1993 , pp. 71 - 78
Copyright
Copyright © Cambridge University Press 1993

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References

Bhargava, S.K. (1987). Antifertility agents from plants. Fit oterapia 59, 163–77.Google Scholar
Bingel, A.S. & Fong, H.H.S.(1988).Potential fertility-regulating agents from plants. Econ. Med. Plant Res. 2, 73–118.Google Scholar
Chen, J.S., Barbetti, M., Menesini Chen, M.G., Sensini, C. & Baccetti, B.(1991). Benzamidine resistant protease in acid extracted bull epididymal spermatozoa. In: Comparative Spermatology Twenty Years After, ed. Baccetti, B. pp. 125–8. Serono Symposia vol. 75. New York: Raven Press.Google Scholar
Giachetti, D., Matteucci, F.,Burrini, A.G., Baccetti, B., Collodel, G. & Piomboni, P. (1991). Effects of Spartium junceufn on male fertility. In: Comparative Spermatology Twenty Years After, ed.Baccetti, B. pp. 829–34. Serono Symposia vol. 75. New York: Raven Press.Google Scholar
International Federation of Clinical Chemistry (1980). Clin. Chim. Acta 105, 147F.Google Scholar
Kong, J.C., Xie, J.X. & But, P.P.H.(1986).Fertility regulating agents from traditional Chinese medicines. J. Ethnopharm acology 15, 1–44.CrossRefGoogle ScholarPubMed
Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randal, R.J.(1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265–75.CrossRefGoogle ScholarPubMed
Lurz, G., Greinwald, R., Witte, L. & Czygan, F.C. (1990). Quinolizidine alkaloids in Spartium junceum. In: Proc. International Joint Symposium on Biology and Chemistry of Active Natural Substances, Bonn, p. 33.Google Scholar
Pei-Gen, X. &Nai-Gong, W. (1991). Can ethnopharmacology contribute to the development of anti-fertility drugs? J. Ethnopharmacol. 32, 167–77.Google Scholar
Waller, D.P., Zaneveld, L.J.D. &Farnsworth, N.R.(1985). Gossypol: pharmacology and current status as a male contraceptive. Econ. Med. Plant Res. 1, 87–112.Google Scholar
Weniger, B.(1982).Plants of Haiti used as antifertility agents. J. Ethnopharmacol. 6, 67–84.CrossRefGoogle ScholarPubMed
Wu, F.C.W. (1988). Male contraception: current status and future prospects. Clin. Endocrinol. 29, 443–65.CrossRefGoogle ScholarPubMed
Younes, M. & Siegers, C.P.(1981). Inhibitory action of some flavonoids on enhanced spontaneous lipid peroxidation following glutathione depletion. Planta Med. 43, 240–4.CrossRefGoogle ScholarPubMed