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Estrogen receptor β localization in the lizard (Podarcis s. sicula) testis

Published online by Cambridge University Press:  24 May 2004

Paolo Chieffi  and
Bruno Varriale
Paolo Chieffi
Affiliation:
Dipartimento di Medicina Sperimentale, II Università di Napoli, Naples, Italy
Bruno Varriale
Affiliation:
Dipartimento di Medicina Sperimentale, II Università di Napoli, Naples, Italy
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Abstract

There is increasing evidence that 17β-estradiol is necessary for normal male fertility. The aim of the present study was to characterize estrogen receptor β (ERβ) expression in a non-mammalian vertebrate model, the lizard (Podarcis s. sicula) testis. Immunocytochemical analysis shows that ERβ proteins are present among germ cells in the nucleus of the spermatogonia, in primary spermatocytes and spermatids. Western blot analysis with antibodies against the ERβ gene product revealed an isoform with a specific weight of 55 kDa. In conclusion, the widespread expression of ERβ in the Podarcis s. sicula testis is consistent with a role for estrogens in modulating spermatogenesis in the male.

Keywords

Estrogen receptorFertilityProliferationSpermatogenesisTestis
Type
Research Article
Information
Zygote , Volume 12 , Issue 1 , February 2004 , pp. 39 - 42
Copyright
2004 Cambridge University Press

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