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Effects of substance exposure on gametes and pre-implantation embryos: a narrative review

Published online by Cambridge University Press:  11 November 2024

Shayesteh Mehdinejadiani ,
Zahra Khosravizadeh ,
Akram Alizadeh  and
Nahid Azad Open the ORCID record for Nahid Azad [Opens in a new window]
Shayesteh Mehdinejadiani
Affiliation:
Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Zahra Khosravizadeh
Affiliation:
Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
Akram Alizadeh
Affiliation:
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Nahid Azad*
Affiliation:
Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran
*
Corresponding author: Nahid Azad; Email: [email protected]
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Abstract

Substance use refers to the consumption of drugs that have varying degrees of impact on a persons’ physical, mental and emotional well-being. While the adverse health effects of drugs have been extensively documented, further research is needed to understand their impact on fertility. Studies have indicated that substance use affects both the male and female reproductive systems. As substance use is more prevalent among young adults compared with the elderly, it appears that individuals of reproductive age are particularly vulnerable to the reproductive impairments associated with substance use. Although numerous studies have reported detrimental effects of substance use on pregnant women and their foetus during the post-implantation stages, there are limited studies on critical pre-implantation period and gamete stages. In this narrative review, we aimed to focus on the most significant evidence regarding the impact of substances on gametes and pre-implantation embryos.

Keywords

druginfertilityoocytepre-implantation embryospermsubstance
Type
Review Article
Information
Zygote , Volume 32 , Issue 6 , December 2024 , pp. 405 - 420
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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