Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-26T04:55:57.089Z Has data issue: false hasContentIssue false
  • English
  • Français

Does cigarette smoking really have a clinical effect on folliculogenesis and oocyte maturation?

Published online by Cambridge University Press:  27 April 2020

Burcu Ozbakir  and
Pinar Tulay Open the ORCID record for Pinar Tulay [Opens in a new window]
Burcu Ozbakir
Affiliation:
Near East University, Faculty of Medicine, Department of Obstetrics and Gynecology, Nicosia, Cyprus Near East University, DESAM Institute, Nicosia, Cyprus
Pinar Tulay*
Affiliation:
Near East University, DESAM Institute, Nicosia, Cyprus Near East University, Faculty of Medicine, Department of Medical Genetics, Nicosia, Cyprus
*
Author for correspondence: Pinar Tulay, Near East University, Faculty of Medicine, Department of Medical Genetics, DESAM Institute, Nicosia, Cyprus, Near East Boulevard, Nicosia North, Cyprus. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Summary

Infertility is the most common issue in the field of reproductive medicine. Many factors affect fertility status, including life-style choices such as cigarette smoking or alcohol use. The aim of this study was to investigate the effects of cigarette smoking on oocyte quality as well the quantity in young fertile women. In total, 56 young fertile women who were undergoing oocyte donation programmes were included in this study. The effects of cigarette smoking on antral follicle count, number of follicles and oocytes retrieved and morphology were assessed by an expert embryologist. The results of this study showed that cigarette smoking did not have a significant effect on the follicle count or the number of oocytes retrieved from young and fertile women. However, a significant difference was observed in the morphological assessment. In conclusion, although cigarette smoking does not seem to affect oocyte development, it had an effect on cytoplasmic anomalies and therefore may lower pregnancy chance. Therefore, it is crucial to give proper counselling to patients who are trying to become pregnant both naturally and by in vitro fertilization.

Keywords

CigaretteFertilityIVFOocyte qualitySmoking
Type
Research Article
Information
Zygote , Volume 28 , Issue 4 , August 2020 , pp. 318 - 321
Copyright
© Cambridge University Press 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barbieri, R, Sluss, P and Powers, R (2005). Association of body mass index, age, and cigarette smoking with serum testosterone levels in cycling women undergoing in vitro fertilization. Fertil Steril 83, 302–8.CrossRefGoogle ScholarPubMed
Budani, M and Tiboni, G (2017). Ovotoxicity of cigarette smoke: A systematic review of the literature. Reprod Toxicol 72, 164–81.CrossRefGoogle ScholarPubMed
Camlin, NJ, Sobinoff, AP, Sutherland, JM, Beckett, EL, Jarnicki, AG, Vanders, RL, Hansbro, PM, McLaughlin, EA and Holt, JE (2016). Maternal smoke exposure impairs the long-term fertility of female offspring in a murine model. Biol Reprod 39, 1–12.Google Scholar
Cinar, O, Dilbaz, S, Terzioglu, F, Karahaili, B, Yucel, C, Turk, R, Taskin, L and Kose, SK (2014). Does cigarette smoking really have detrimental effects on outcomes of IVF? Eur J Obstet Gynecol Reprod Biol 174, 106–10.CrossRefGoogle ScholarPubMed
Das, S, Chattopadhyay, R, Ghosh, S, Goswami, S, Chakravarty, B and Chaudhury, K (2006). Reactive oxygen species level in follicular fluid – embryo quality marker in IVF? Hum Reprod 21, 2403–7.CrossRefGoogle ScholarPubMed
Dechanet, C, Anahory, T, Daude, J, Quantin, X, Reyftmann, L and Hamamah, S (2011). Effects of cigarette smoking on reproduction. Hum Reprod Update 17, 76–95.CrossRefGoogle ScholarPubMed
El-Nemr, A, Al-Shawaf, T, Sabatini, L, Wilson, C, Lower, A and Grudzinskas, J (1998). Effect of smoking on ovarian reserve and ovarian stimulation in in-vitro fertilization and embryo transfer. Hum Reprod 13, 2192–8.CrossRefGoogle ScholarPubMed
Fowles, J and Dybing, E (2003). Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob Control 12, 424–30.CrossRefGoogle ScholarPubMed
Freour, T, Masson, D, Dessolle, L, Allaoua, D, Dejoie, T and Mirallie, S (2012). Ovarian reserve and in vitro fertilization cycles outcome according to women smoking status and stimulation regimen. Arch Gynecol Obstet 285, 1177–82.CrossRefGoogle ScholarPubMed
Fuentes, A, Munoz, A, Barnhart, K, Arguello, B, Diaz, M and Pommer, R (2010). Recent cigarette smoking and assisted reproductive technologies outcome. Fertil Steril 93, 89–95.CrossRefGoogle ScholarPubMed
Gruber, I, Just, A, Birner, M and Lösch, A (2008). Effect of a woman’s smoking status on oocyte, zygote, and day 3 pre-embryo quality in in vitro fertilization and embryo transfer program. Fertil Steril 90, 1249–52.CrossRefGoogle ScholarPubMed
Harrison, KL, Breen, TM, and Hennessey, JF (1990). The effect of patient smoking habit on the outcome of IVF and GIFT treatment. Aust N Z J Obstet Gynaecol 30, 340–2.CrossRefGoogle ScholarPubMed
Hassa, H, Gurer, F and Tanir, HM (2007). Effect of cigarette smoke and alpha- tocopherol (vitamin E) on fertilization, cleavage, and embryo development rates in mice: an experimental in vitro fertilization mice model study. Eur J Obstet Gynecol Reprod Biol 135, 177–82.CrossRefGoogle ScholarPubMed
Huang, J, Okuka, M, McLean, M, Keefe, DL and Liu, L (2010). Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro. Free Radic Biol Med 48, 1663–1676.CrossRefGoogle ScholarPubMed
Jennings, P, Merriman, J, Beckett, E, Hansbro, P and Jones, KT (2011). Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking mice. Reprod Biol 26, 878–84.Google ScholarPubMed
Kazemi, A, Ramezanzadeh, F, Esfahani, MH, Saboor-Yaraghi, AA, Nejat, S and Rahimi-Foroshani, A (2013). Impact of environmental tobacco smoke exposure in women on oxidative stress in the antral follicle and assisted reproduction outcomes. J Res Med Sci 18, 688–94.Google ScholarPubMed
Kharrazi, M, DeLorenze, G and Kaufman, F (2004). Environmental tobacco smoke and pregnancy outcome. Epidemiology 15, 660–70.CrossRefGoogle ScholarPubMed
Kinney, A, Kline, J, Kelly, A, Reuss, ML and Levin, B (2007). Smoking, alcohol and caffeine in relation to ovarian age during the reproductive years. Hum Reprod 22, 1175–85.CrossRefGoogle ScholarPubMed
Klonoff-Cohen, H, Natarajan, L, Marrs, R and Yee, B (2001). Effects of female and male smoking on success rates of IVF and gamete intra-fallopian transfer. Hum Reprod 16, 1382–90.CrossRefGoogle ScholarPubMed
Lambert-Messerlian, G and Harlow, B (2006). The influence of depression, body mass index, and smoking on serum inhibin B levels in late reproductive-aged women. J Clin Endocrinol Metab 91, 1496–500.CrossRefGoogle ScholarPubMed
Mai, Z, Lei, M, Yu, B, Du, H and Liu, J (2014). The effects of cigarette smoke extract on ovulation, oocyte morphology and ovarian gene expression in mice. PLoS One 9, e95945.CrossRefGoogle ScholarPubMed
Mailhes, JB, Young, D, Caldito, G and London, SN (2000). Sensitivity of mouse oocytes to nicotine-induced perturbations during oocyte meiotic maturation and aneuploidy in vivo and in vitro. Mol Hum Reprod 6, 232–7.CrossRefGoogle ScholarPubMed
Neal, MS, Hughes, EG, Holloway, AC and Foster, WG (2005). Sidestream smoking is equally as damaging as mainstream smoking on IVF outcomes. Hum Reprod 20, 2531–5.CrossRefGoogle ScholarPubMed
Neal, MS, Zhu, J and Foster, WG (2008). Quantification of benzo-[a]-pyrene and other PAHs in the serum and follicular fluid of smokers versus non-smokers. Reprod Toxicol 25, 100–6.CrossRefGoogle ScholarPubMed
Paixao, LL, Gaspar-Reis, RP, Gonzalez, GP, Santos, AS, Santana, AC, Santos, RMM, Spritzer, PM and Nascimento-Saba, CCA (2012). Cigarette smoke impairs granulosa cell proliferation and oocyte growth after exposure cessation in young Swiss mice: an experimental study. J Ovarian Res 5, 25.CrossRefGoogle ScholarPubMed
Pattinson, HA, Taylor, P and Pattinson, MH (1991). The effect of cigarette smoking on ovarian function and early pregnancy outcome of in vitro fertilization treatment. Fertil Steril 55, 780–3.CrossRefGoogle ScholarPubMed
Richardson, MC, Guo, M, Fauser, BC and Macklo, NS (2014). Environmental and developmental origins of ovarian reserve. Hum Reprod Update 20, 353–69.CrossRefGoogle ScholarPubMed
Sadeu, JC and Foster, WG (2011a). Effect of in vitro exposure to benzo-[a]-pyrene, a component of cigarette smoking, on folliculogenesis, steroidogenesis and oocyte nuclear maturation. Reprod Toxicol 31, 402–8.CrossRefGoogle Scholar
Sadeu, JC and Foster, WG (2011b). Cigarette smoking condensate exposure delays follicular development and function in a stage-dependent manner. Fertil Steril 95, 2410–7.CrossRefGoogle Scholar
Shiloh, H, LahavBaratz, S, Koifman, M, Ishai, D, Bidder, D and Weiner-Meganzi, Z (2004). The effect of cigarette smoking on zona pellucida thickness of oocytes and embryos prior to transfer into the uterine cavity. Hum Reprod 19, 157–9.CrossRefGoogle ScholarPubMed
Soldin, OP, Makamb, KHi, Soldin, SJ and O’Mara, DM (2011). Steroid hormone levels associated with passive and active smoking. Steroids 76, 653–9.CrossRefGoogle ScholarPubMed
Sterzik, K, Strehler, E and De Santo, M (1996). Influence of smoking on fertility in women attending an in vitro fertilization program. Fertil Steril 65, 810–4.CrossRefGoogle ScholarPubMed
Strohsnitter, WC, Hatch, EE, Hyer, M, Troisi, R, Kaufman, RH, Robboy, SJ, Palmer, JR, Titus-Ernstoff, L, Anderson, D, Hoover, RN and Noller, KL (2008). The association between in utero cigarette smoke exposure and age at menopause. Am J Epidemiol 167, 727–33.CrossRefGoogle ScholarPubMed
Tiboni, GM, Bucciarelli, T, Giampietro, F, Sulplizio, M and Ilio, CD (2004). Influence of cigarette smoking on vitamin E, vitamin A, β-carotene and lycopene concentrations in human pre-ovulatory follicular fluid. Int J Immunopathol Pharmacol 17, 389–93.CrossRefGoogle ScholarPubMed
Van Voorhis, BJ, Syrop, CH, Hammitt, DG, Dunn, MS and Snyder, GD (1992). Effects of smoking on ovulation induction for assisted reproductive techniques. Fertil Steril 58, 981–5.CrossRefGoogle ScholarPubMed
Vrsanska, S, Nagyova, E, Miynarcikova, A, Fickova, M and Kolena, J (2003). Components of cigarette smoke inhibit expansion of oocyte cumulus complexes from porcine follicles. Physiol Res 52, 383–7.Google ScholarPubMed
Weigert, M, Hofstetter, G and Kaipl, D (1999). The effect of smoking on oocyte quality and hormonal parameters of patients undergoing in vitro fertilization–embryo transfer. J Assist Reprod Genet 16, 287–93.CrossRefGoogle ScholarPubMed
Wright, K, Trimarchi, J, Allsworth, J and Keefe, D (2006). The effect of female tobacco smoking on IVF outcomes. Hum Reprod 21, 2930–4.CrossRefGoogle ScholarPubMed