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A case report of a successful pregnancy after intracytoplasmic sperm injection when all oocytes contained abnormal inclusions in the perivitelline space

Published online by Cambridge University Press:  21 March 2025

Juan Peng ,
Wenda Zou ,
Liyu Zhu ,
Xinlin Guo ,
Juan Zhang  and
Hui Li Open the ORCID record for Hui Li [Opens in a new window]
Juan Peng
Affiliation:
Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, HN, China
Wenda Zou
Affiliation:
Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, HN, China
Liyu Zhu
Affiliation:
Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, HN, China
Xinlin Guo
Affiliation:
Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, HN, China
Juan Zhang
Affiliation:
Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, HN, China
Hui Li*
Affiliation:
Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, HN, China
*
Corresponding author: Hui Li; Email: [email protected]
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Abstract

Background:

The relationship between oocyte morphology and developmental potential has been a hot research topic in assisted reproductive technology (ART). Whether inclusions in the perivitelline space (PVS) affect ART outcomes remains controversial.

Case Presentation:

We present a case report of a 34-year-old G3P1A2 woman who sought ART treatment because of sequelae of pelvic disease. As her husband had severe oligospermia due to the stress on the day of oocyte retrieval, intracytoplasmic sperm injection (ICSI) was performed. After denudation, varying degrees of debris were found in the PVS, but all the oocytes were subjected to ICSI. Among the eleven retrieved oocytes, eight were fertilized. The morphology of the embryos was scored on Days 2 and 3. Five embryos were frozen on Day 3, and two best-quality embryos were subsequently transferred via frozen embryo transfer.

Conclusion:

Severe debris in the PVS seems to affect embryo quality but not fertilization. Mild debris in the PVS may have little effect on the outcome of ART treatment. In our patient, after two embryos that were derived from oocytes with relatively few debris in the PVS were transferred, a successful live birth occurred.

Keywords

case reportdebrisembryoperivitelline spaceoocyte
Type
Research Article
Information
Zygote , First View , pp. 1 - 6
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Copyright
© The Author(s), 2025. Published by Cambridge University Press

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