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The role of propofol on mouse oocyte meiotic maturation and early embryo development

Published online by Cambridge University Press:  16 July 2018

Xia-Guang Duan ,
Zai-Qing Huang ,
Chun-Guang Hao ,
Xiao-Jun Zhi ,
Xiao-Bing Qi ,
Ling Ren ,
Sheng-Hui Luan  and
Cheng-Guang Liang
Xia-Guang Duan
Affiliation:
The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, The Research Center for Laboratory Animal Science, College of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia, People’s Republic of China Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Zai-Qing Huang
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Chun-Guang Hao
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Xiao-Jun Zhi
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Xiao-Bing Qi
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Ling Ren
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Sheng-Hui Luan
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Cheng-Guang Liang*
Affiliation:
The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, The Research Center for Laboratory Animal Science, College of Life Science, Inner Mongolia University, No. 24 Zhao Jun Road, Hohhot, Inner Mongolia, People’s Republic of China
*
1All correspondence to: Cheng-Guang Liang, E-mail: [email protected]
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Summary

Propofol is a intravenous anaesthetic most commonly used in ultrasound oocyte retrieval. We studied if the use of propofol had an effect on mouse oocyte maturation, pregnancy, childbirth and progeny and investigated the correlation between propofol side effects and reproductive performance in mice. There was no statistical difference in mating, pregnancy, childbirth, litter size, the number of stillbirths and survival between each group (P>0.05). Propofol also had no effect on polar body extrusion in oocyte maturation as well as on pronucleus formation and, subsequently, early embryo development (P>0.05). An increased concentration of propofol had no effect on this result, although propofol at more than 0.01 mg/ml reduced polar body extrusion. Different concentrations of propofol had no effect on oocyte culture in vitro, pronucleus formation and early embryo development.

Keywords

DeliveryEmbryo developmentLive birth ratesOocytePropofol
Type
Research Article
Information
Zygote , Volume 26 , Issue 4 , August 2018 , pp. 261 - 269
Copyright
© Cambridge University Press 2018 

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