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Relationship of polar bodies morphology to embryo quality and pregnancy outcome

Published online by Cambridge University Press:  22 July 2015

Wenhui Zhou ,
Lei Fu ,
Wei Sha ,
Dapeng Chu  and
Yuan Li
Wenhui Zhou
Affiliation:
Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Lei Fu
Affiliation:
Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Wei Sha
Affiliation:
Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Dapeng Chu
Affiliation:
Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Yuan Li*
Affiliation:
Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China
*
All correspondence to: Yuan Li. Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China. Tel: +86 010 85231423. E-mail: [email protected]
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Summary

The aim of this study was to explore whether the morphology of polar bodies (PBs) estimated at 16–18 h after insemination can be used as an additional marker for predicting human embryo quality or pregnancy outcome. The data from 355 patients who received standard in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment after controlled ovarian hyperstimulation were recruited. Normal fertilized 3048 zygotes from 382 cycles were divided into two groups, PBs intact or fragmented, according to the morphology of PBs assessed at 16–18 h after insemination. Embryo quality and pregnancy outcome were compared between the two groups. It was shown that the day 3 (D3) good embryo rate, good quality blastocyst rate and available embryo rate of the PBs intact group were all significantly higher than that of the corresponding fragmented groups. However, no significant differences in pregnancy rate (PR) or implantation rate (IR) were observed between the intact and fragmented groups. Although PBs morphology estimated at 16–18 h after insemination had little effect on PR or IR in fresh embryo transfer cycles, a better embryo quality can be achieved in the PB-intact group, which is valuable for embryo selection.

Keywords

Embryo qualityImplantation ratePolar body morphologyPregnancy rateZygote competence
Type
Research Article
Information
Zygote , Volume 24 , Issue 3 , June 2016 , pp. 401 - 407
Copyright
Copyright © Cambridge University Press 2015 

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Footnotes

3

These authors contributed equally to this work.

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