Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-03T00:29:33.422Z Has data issue: false hasContentIssue false

Oocyte-secreted factros regulate granulosa cell steroidogenesis

Published online by Cambridge University Press:  26 September 2008

Barbara C. Vanderhyden*
Affiliation:
Ottawa Regional Cancer Centre, and Departments of Medicine, Physiology, and Obstetrics & Gynecology, University of Ottawa, Ottawa, Ontario, Canada.
*
Dr Barbara Vanderhyden, Ottawa Regional Cancer Centre, Cancer Research Laboratories, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6. Telephone: +1(613)247-6895. Fax: +1(613) 247-6897. e-mail: [email protected].

Extract

Investigations of strains of mice defective in germ cell development have revealed the importance of oocytes for the initial stages of folliculogenesis (Pellas et al., 1991; Huang et al., 1993). Various aspects of follicular development are dependent upon and/or influenced by the presence of oocytes, including granulosa cell proliferation (Vanderhyden et al., 1990, 1992) and cumulus expansion (Buccione et al., 1990; Salustri et al., 1990; Vanderhyden et al., 1990; Vanderhyden, 1993). We are investigating the possibility that oocytes influence one of the primary functions of granulosa cells: steroidogenesis. In many species, granulosa cells removed from preovulatory follicles luteinise in vitro (Channing et al., 1982), presumably due to loss of contact with follicular luteinisation inhibitory factor(s). Indeed, follicular fluid can prevent granulosa cell luteinisation in vitro (Ledwitz-Rigby et al., 1977). Follicular fluid, however, may simply be the medium for transport of factors secreted by oocytes to regulate granulosa cell activities.

Type
Article
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Buccione, R., Vanderhyden, B.C., Caron, P.J. & Eppig, J.J. (1990). FSH–induced expansion of the mouse cumulus oophorus in vitro is dependent upon a specific factor(s) secreted by the oocyte. Dev. Biol. 138, 1625CrossRefGoogle ScholarPubMed
Channing, C.P. & Tsafriri, A. (1977). Lack of an inhibitory influence of oocytes upon luteinisation of porcine granulosa cells in culture. J. Reprod. Fert. 50, 103–5.CrossRefGoogle ScholarPubMed
Channing, C.P., Anderson, L.D., Hoover, D.J., Kolena, J., Osteen, K.G., Pomerantz, S.H. & Tanabe, K. (1982). The role of nonsteroidal regulators in control of oocyte and follicular maturation. Recent Prog. Horm. Res. 38, 331400.Google ScholarPubMed
Coskun, S., Uzumcu, M., Lin, Y.C., Friedman, C.I. & Alak, B.M. (1995).Regulation of cumulus cell Steroidogenesis by the porcine oocyte and preliminary characterisation of oocyte-produced factor(s). Biol. Reprod. 53, 670–5.CrossRefGoogle ScholarPubMed
El-Fouly, M.A., CooK, B., Nekola, M. & Nalbandov, A.V. (1970). Role of the ovum in follicular luteinisation. Endocrinology. 87, 288–93.CrossRefGoogle Scholar
Hillier, S.G., Knazek, R.A. & Ross, G.T.(1977). Androgenic stimulation of progesterone production by granulosa cells from preantral ovarian follicles: further in vitro studies using replicate cell cultures. Endocrinology. 100. 1539–49.CrossRefGoogle ScholarPubMed
Huang, E.J., Manova, K., Packer, A.I., Sanchez, S., Bachvarova, R.F. & Besmer, P. (1993). The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles. Dee. Biol. 157, 101–9.Google ScholarPubMed
Hubbard, G.M. & Erickson, G.F. (1988). Luteinizing hormone–dependent luteinisation and ovulation in the hypophysectomised rat: a possible role for the oocyte? Biol. Reprod. 39, 183194.CrossRefGoogle Scholar
Ledwitz-Rigby, F., Rigby, B.W., Gay, V.L., Stetron, M., Young, J. & Channing, C.P. (1977). Inhibitory action of porcine follicular fluid upon granulosa cell luteinisation in vitro: assay and influence of follicular maturation. J. Endocrinol. 74, 175–84.CrossRefGoogle ScholarPubMed
Lindner, H.R., Tsafriri, A., Lieberman, M.E., Zor, U., Koch, Y., Bauminger, S. & Bamea, A. (1974). Gonadotropin action on cultured Graafian follicles: induction of maturation division of the mammalian oocyte and differentiation of the luteal cell. Recent Prog. Horm. Res. 30, 79138.Google ScholarPubMed
Nekola, M.V. & Nalbandov, A.V. (1971). Morphological changes of rat follicular cells as influenced by oocytes. Biol. Reprod. 4, 154–60.CrossRefGoogle ScholarPubMed
Nicosia, S.V. (1972). Luteinisation of rabbit preovulatory granulosa cells cultured in vitro in presence of follicular oocytes. I. Growth characteristics and progestin biosynthesis. Fert. Steril. 23, 791801.CrossRefGoogle ScholarPubMed
Pellas, T.C., Ramachandran, B., Duncan, M., Pan, S.S., Marone, M. & Chada, K. (1991). Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice. Proc. Natl. Acad. Sci. USA 88, 8787–91CrossRefGoogle ScholarPubMed
Salustri, A., Yanagishita, M. & Hascall, V.C. (1990). Mouse oocytes regulate hyaluronic acid synthesis and mucification by FSH-stimulated cumulus cells. Dev. Biol. 138, 2632.CrossRefGoogle ScholarPubMed
Seifer, D.B., Freeman, M.R., Gardiner, A.C., Hill, G.A., Schneyer, A.L. & Vanderhyden, B.C. (1996). Autologous granulosa cell coculture demonstrates zygote suppression of granulosa cell steroidogenesis. Fert. Steril. 66, 425–9.CrossRefGoogle ScholarPubMed
Stoklosowa, S. & Nalbandov, A.V. (1972). Luteinisation and steroidogenic activity of rat ovarian follicles cultured in vitro. Endocrinology 91, 2532.CrossRefGoogle Scholar
Vanderhyden, B.C. (1993). Species difference in the regulation of cumulus expansion by an oocyte-secreted factor(s). J. Reprod. Fertil. 98, 219–27.CrossRefGoogle ScholarPubMed
Vanderhyden, B.C. & Tonary, A.M. (1995). Differential regulation of progesterone and oestradiol production by mouse cumulus and mural granulosa cells by a factor(s) secreted by the oocyte. Biol. Reprod. 53, 1243–50.CrossRefGoogle ScholarPubMed
Vanderhyden, B.C., Caron, P.J., Buccione, R. & Eppig, J.J. (1990). Developmental pattern of the secretion of cumulus expansion-enabling factor by mouse oocytes and the role of oocytes in promoting granulosa cell differentiation. Dev. Biol. 140, 307–17.CrossRefGoogle ScholarPubMed
Vanderhyden, B.C., Cohen, J.N. & Morley, P. (1993). Mouse oocytes regulate granulosa cell steroidogenesis. Endocrinology. 133, 423–6.CrossRefGoogle ScholarPubMed
Vanderhyden, B.C., Telfer, E.E. & Eppig, J.J. (1992) Mouse oocytes promote proliferation of granulosa cells from preantral and antral follicles in vitro. Biol. Reprod. 46. 1196–204.CrossRefGoogle ScholarPubMed
Wallace, R.A. (1983). Interactions between somatic and the growing oocyte of Xenopus laevis. In Current Problems in Germ Cells, ed. McLaren, A. & Wylie, C.C., pp. 285306. Cambridge: Cambridge University Press.Google Scholar
Yoshimura, Y., Tischkau, S.A. & Bahr, J.M. (1994). Destruction of the germinal disc region of an immature preovulatory follicle suppresses follicular maturation and ovulation. Biol. Reprod. 51, 229–33.CrossRefGoogle ScholarPubMed