Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-22T09:12:23.683Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of in vitro exposure of sheep ovarian tissue to zearalenone and matairesinol on preantral follicles

Published online by Cambridge University Press:  25 October 2021

D.C.C. Brito ,
I.P. Silva ,
A.C.A. Ferreira ,
N.A.R. Sá ,
M.I.F. Guedes ,
A.P.R. Rodrigues ,
R.R. Santos Open the ORCID record for R.R. Santos [Opens in a new window]  and
J.R. Figueiredo
D.C.C. Brito
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
I.P. Silva
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
A.C.A. Ferreira
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
N.A.R. Sá
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
M.I.F. Guedes
Affiliation:
Laboratory of Biotechnology and Molecular Biology (LBBM), State University of Ceará, Fortaleza60714-903, CE, Brazil
A.P.R. Rodrigues
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
R.R. Santos*
Affiliation:
Schothorst Feed Research, 8218 NA Lelystad, The Netherlands
J.R. Figueiredo
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-Antral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceará, Fortaleza60714-903, CE, Brazil
*
Author for correspondence: R.R. Santos. Schothorst Feed Research, 8218 NA Lelystad, The Netherlands. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Summary

The aim of this study was to evaluate the effect of 1 µmol/l zearalenone (ZEN) and 1 µmol/l matairesinol (MAT), alone or in combination, on the morphology of in vitro-cultured ovarian preantral follicles. Ovaries from four adult sheep were collected at a local slaughterhouse and fragmented, and the ovarian pieces were submitted to in vitro culture for 3 days in the presence or absence of the test compounds. The morphology of primordial and primary follicles was impaired by ZEN. The plant lignan MAT alone did not maintain the morphology of the ovarian follicles; its combination with ZEN counteracted the negative effects observed when follicles were cultured in the presence of the mycotoxin alone. However, MAT was not able to promote the in vitro development of the ovarian follicles.

Keywords

Follicular developmentHistologyIn vitro cultureMycoestrogenPhytoestrogen
Type
Short Communication
Information
Zygote , Volume 30 , Issue 3 , June 2022 , pp. 419 - 422
Copyright
© The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abir, R, Roizman, P, Fisch, B, Nitke, S, Okon, E, Orvieto, R and Ben Rafael, Z (1999). Pilot study of isolated early human follicles cultured in collagen gels for 24 hours. Hum Reprod 14, 1299–301.CrossRefGoogle ScholarPubMed
Abir, R, Fisch, B, Nitke, S, Okon, E, Raz, A and Ben Rafael, Z (2001). Morphological study of fully and partially isolated early human follicles. Fertil Steril 75, 141–6.CrossRefGoogle ScholarPubMed
Asadi-Azarbaijani, B, Santos, RR, Jahnukainen, K, Braber, S, van Duursen, MBM, Toppari, J, Saugstad, OD, Nurmio, M and Oskam, IC (2017). Developmental effects of imatinib mesylate on follicle assembly and early activation of primordial follicle pool in postnatal rat ovary. Reprod Biol 17, 25–33.CrossRefGoogle ScholarPubMed
Barbasz, A, Rudolphi-Skórska, E, Filek, M and Janeczko, A (2019). Exposure of human lymphoma cells (U-937) to the action of a single mycotoxin as well as in mixtures with the potential protectors 24-epibrassinolide and selenium ions. Mycotoxin Res 35, 89–98.CrossRefGoogle Scholar
Brito, AB, Brito, DCC, Silva, WB, Rodrigues, APR, Figueiredo, JR, Domingues, SFS and Santos, RR (2018). Morphology and morphometry of preantral follicles, and immunolocalization of angiogenic factors in ovarian tissue from the Neotropical primate Sapajus apella . Zygote 26, 424–9.CrossRefGoogle ScholarPubMed
Brito, AB, Santos, RR, van den Hurk, R, Lima, JS, Miranda, MS, Ohashi, OM and Domingues, SFS (2013). Short-term culture of ovarian cortical strips from capuchin monkeys (Sapajus apella): a morphological, viability, and molecular study of preantral follicular development in vitro . Reprod Sci 20, 990–7.CrossRefGoogle ScholarPubMed
Caroprese, M, Ciliberti, MG, Albenzio, M, Annicchiarico, G and Sevi, A (2015). Dietary polyunsaturated fatty acids from flaxseed affect immune responses of dairy sheep around parturition. Vet Immunol Immunopathol 168, 56–60.CrossRefGoogle ScholarPubMed
Didarkhah, M, Vatandoost, M, Dirandeh, E and Dadashpour Davachi, N (2020). Effects of flaxseed-rich diet on reproductive performance in estrous-synchronized baluchi ewes. Arch Razi Inst 75, 397–404.Google ScholarPubMed
Draper, HH and Hadley, M (1990). Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186, 421–31.CrossRefGoogle ScholarPubMed
Green, LC, Tannenbaum, SR and Goldman, P (1981). Nitrate synthesis in the germfree and conventional rat. Science 212, 56–8.CrossRefGoogle ScholarPubMed
Hueza, IM, Raspantini, PCF, Raspantini, LER, Latorre, AO and Górniak, SL (2014). Zearalenone, an estrogenic mycotoxin, is an immunotoxic compound. Toxins 6, 1080–95.CrossRefGoogle ScholarPubMed
Hunter, MG, Robinson, RS, Mann, GE and Webb, R (2004). Endocrine and paracrine control of follicular development and ovulation rate in farm species. Anim Reprod Sci 82–83, 461–77, 461–77.CrossRefGoogle ScholarPubMed
Lass, A, Silye, R, Abrams, DC, Krausz, T, Hovatta, O, Margara, R and Winston, RM (1997). Follicular density in ovarian biopsy of infertile women: a novel method to assess ovarian reserve. Hum Reprod 12, 1028–31.CrossRefGoogle ScholarPubMed
Lee, B, Kim, KH, Jung, HJ and Kwon, HJ (2012). Matairesinol inhibits angiogenesis via suppression of mitochondrial reactive oxygen species. Biochem Biophys Res Commun 421, 76–80.CrossRefGoogle ScholarPubMed
Liggins, J, Grimwood, R and Bingham, SA (2000). Extraction and quantification of lignan phytoestrogens in food and human samples. Anal Biochem 287, 102–9.CrossRefGoogle ScholarPubMed
Niemeyer, HB, Honig, DM, Kulling, SE and Metzler, M (2003). Studies on the metabolism of the plant lignans secoisolariciresinol and matairesinol. J Agric Food Chem 51, 6317–25.CrossRefGoogle Scholar
Otero, JA, García-Mateos, D, Alvarez-Fernández, I, García-Villalba, R, Espín, JC, Álvarez, AI and Merino, G (2018). Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep. BMC Vet Res 14, 14.CrossRefGoogle ScholarPubMed
Qin, X, Cao, M, Lai, F, Yang, F, Ge, W, Zhang, X, Cheng, S, Sun, X, Qin, G, Shen, W and Li, L (2015). Oxidative stress induced by zearalenone in porcine granulosa cells and its rescue by curcumin in vitro . PLOS ONE 10, e0127551.CrossRefGoogle ScholarPubMed
Rogowska, A, Pomastowski, P, Sagandykova, G and Buszewski, B (2019). Zearalenone and its metabolites: effect on human health, metabolism and neutralisation methods. Toxicon 162, 46–56.CrossRefGoogle ScholarPubMed
Sales, AD, Duarte, AB, Santos, RR, Alves, KA, Lima, LF, Rodrigues, GQ, Brito, IR, Lobo, CH, Bruno, JB, Locatelli, Y, Figueiredo, JR and Rodrigues, APR (2016). Modulation of aquaporins 3 and 9 after exposure of ovine ovarian tissue to cryoprotectants followed by in vitro culture. Cell Tissue Res 365, 415–24.CrossRefGoogle ScholarPubMed
Samik, A and Safitri, E (2017). Mycotoxin binders potential on histological of ovary mice exposed by zearalenone. Vet World 10, 353–7.CrossRefGoogle ScholarPubMed
Santos, RR, Rodrigues, AP, Costa, SH, Silva, JR, Matos, MH, Lucci, CM, Báo, SN, van den Hurk, R and Figueiredo, JR (2006). Histological and ultrastructural analysis of cryopreserved sheep preantral follicles. Anim Reprod Sci 91, 249–63.CrossRefGoogle ScholarPubMed
Santos, RR, Vermeulen, S, Haritova, A and Fink-Gremmels, J (2011). Isotherm modeling of organic activated bentonite and humic acid polymer used as mycotoxin adsorbents. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 28, 1578–89.CrossRefGoogle ScholarPubMed
Santos, RR, Schoevers, EJ, Roelen, BAJ and Fink-Gremmels, J (2013). Mycotoxins and female reproduction: in vitro approaches. World Mycotoxin J 6, 245–53.CrossRefGoogle Scholar
Schoevers, EJ, Santos, RR, Colenbrander, B, Fink-Gremmels, J and Roelen, BAJ (2012). Transgenerational toxicity of zearalenone in pigs. Reprod Toxicol 34, 110–9.CrossRefGoogle ScholarPubMed
Silva, TES, de Brito, DCC, de Sá, NAR, da Silva, RF, Ferreira, ACA, da Silva, JYG, Guedes, MIF, Rodrigues, APR, Dos Santos, RR and de Figueiredo, JR (2019). Equol: a microbiota metabolite able to alleviate the negative effects of zearalenone during in vitro culture of ovine preantral follicles. Toxins 11, 652.CrossRefGoogle ScholarPubMed