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Super-dosing effects of phytase in poultry and other monogastrics

Published online by Cambridge University Press:  20 June 2011

A.J. COWIESON ,
P. WILCOCK  and
M.R. BEDFORD
A.J. COWIESON
Affiliation:
Poultry Research Foundation, Faculty of Veterinary Science, University of Sydney, Camden, NSW 2570, Australia
P. WILCOCK
Affiliation:
AB Vista Feed Ingredients, 3 Woodstock Court, Blenheim Road, Marlborough Business Park, Marlborough, Wiltshire, UK, SN8 4AN
M.R. BEDFORD*
Affiliation:
AB Vista Feed Ingredients, 3 Woodstock Court, Blenheim Road, Marlborough Business Park, Marlborough, Wiltshire, UK, SN8 4AN
*
Corresponding author: [email protected]
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Abstract

Phytases have been used commercially since the early 1990s and have been the focus of considerable and sustained research for many decades. Despite this heroic effort there are still areas of persistent uncertainty such as the obscurity surrounding total compared with digestible calcium, appropriate modification to dietary sodium (and other electrolyte) concentrations, the usefulness of the amino acid and energy digestibility improvements and ultimately the effect of phytase on nutrient requirement. One further area which has attracted some attention recently is the effect of unconventionally high doses of phytase (i.e. >2,500 FTU/kg from Aspergillus niger or Escherichia coli) in an attempt to ostensibly ‘de-phytinise’ the diet. The effects of such ‘super’ doses of phytase can be considerable, and often beyond that which may be reasonably expected based on improvement in P digestibility per se. This review article addresses these effects and suggests mechanisms by which they may be explained.

Keywords

phytasedosagephytateinositolmonogastrics
Type
Review Article
Information
World's Poultry Science Journal , Volume 67 , Issue 2 , June 2011 , pp. 225 - 236
Copyright
Copyright © World's Poultry Science Association 2011

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References

AGRANOFF, B.W. and SPIVEY-FOX, M.R. (1959) Antagonism of choline and inositol. Nature 183: 1259-1260.CrossRefGoogle ScholarPubMed
ANGEL, R. and APPLEGATE, T. (2002) Phytase use – what do we know? Proceedings of the 62nd Minnesota Nutrition Conference, pp: 1-15.Google Scholar
AUGSPURGER, N.R. and BAKER, D.H. (2004) High dietary phytase levels maximize phytate-phosphorus utilization but do not affect protein utilization in chicks fed phosphorus- or amino acid-deficient diets. Journal of Animal Science 82: 1100-1107.CrossRefGoogle ScholarPubMed
BIRGE, S.J. and AVIOLI, R.C. (1981) Intestinal phosphate transport and alkaline phosphatase activity in the chick. American Journal of Physiology (Endocrinology Metabolism) 240: 384-390.CrossRefGoogle ScholarPubMed
BRANA, D.V., ELLIS, M., CASTANEDA, E.O. and SANDS, J.S. (2006) Effect of a novel phytase on growth performance, bone ash, mineral digestibility in nursery and grower-finisher pigs. Journal of Animal Science 84: 1839-1849.CrossRefGoogle ScholarPubMed
CLEMENTS, R.S. and DARNELL, B. (1980) Myo-inositol content of common foods: development of a high-myo-inositol diet. American Journal of Clinical Nutrition 33: 1954-1967.CrossRefGoogle ScholarPubMed
COSTELLO, A.J.R., GLONEK, T. and MYERS, T.C. (1976) 31P nuclear magnetic resonance-pH titrations of myo-inositol hexaphosphate. Carbohydrate Chemistry 46: 159-171.CrossRefGoogle ScholarPubMed
COWIESON, A.J. and RAVINDRAN, V. (2007) Effect of phytic acid and microbial phytase on the flow and amino acid composition of endogenous protein at the terminal ileum of growing broiler chickens. British Journal of Nutrition 98: 745-752.CrossRefGoogle ScholarPubMed
COWIESON, A.J., ACAMOVIC, T. and BEDFORD, M.R. (2004) The effect of phytase and phytic acid on endogenous losses from broiler chickens. British Poultry Science 45: 101-108.CrossRefGoogle ScholarPubMed
COWIESON, A.J., ACAMOVIC, T. and BEDFORD, M.R. (2006) Phytic acid and phytase: implications for protein utilization by poultry. Poultry Science 85: 878-885.CrossRefGoogle ScholarPubMed
COWIESON, A.J., BEDFORD, M.R., SELLE, P.H. and RAVINDRAN, V. (2009) Phytate and microbial phytase: implications for endogenous nitrogen losses and nutrient availability. World's Poultry Science Journal 65: 401-418.CrossRefGoogle Scholar
COWIESON, A.J., RAVINDRAN, V. and SELLE, P.H. (2008) Influence of dietary phytic acid and source of microbial phytase on ileal endogenous amino acid flows in broiler chickens. Poultry Science 87: 2287-2299.CrossRefGoogle ScholarPubMed
COWIESON, A.J. and COWIESON, N.P. (2011) Phytate and the thermodynamics of water. Proceedings of the Australian Poultry Science Symposium. In press.Google Scholar
DAM, H. (1944) Studies on vitamin E deficiency in chicks. Journal of Nutrition 27: 193-211.CrossRefGoogle Scholar
DRIVER, J.P., PESTI, G.M., BAKALLI, R.I. and EDWARDS, H.M. (2005) Effects of calcium and nonphytate phosphorus concentrations on phytase efficacy in broiler chicks . Poultry Science 84: 1406-1417.CrossRefGoogle ScholarPubMed
EASTCOTT, E.V. (1928) The isolation and identification of "Bios 1". Journal of Physical Chemistry 32: 1094-1111.CrossRefGoogle Scholar
GAVIN, G. and McHENRY, E.W. (1941) The effects of biotin upon fat synthesis and metabolism. Journal of Biological Chemistry 141: 619-625.CrossRefGoogle Scholar
GREINER, R. and FAROUK, A. (2007) Purification and characterisation of a bacterial phytase whose properties make it exceptionally useful as a feed supplement. The Protein Journal 26: 467-474.CrossRefGoogle ScholarPubMed
HARLAND, B.F. and MORRIS, E.R. (1995) Phytate: A good or bad food component? Nutrition Research 15: 733-754.CrossRefGoogle Scholar
HARMS, R.H., WALDROUP, P.W., SHIRLEY, R.L. and AMMERMAN, C.B. (1962) Availability of phytic acid phosphorus for chicks. Poultry Science 41: 1189-1991.CrossRefGoogle Scholar
HARTIG, T. (1855) . Uber das klebermehl. Botanische Zeitung 13: 881-885.Google Scholar
HEGSTED, D.M., MILLS, R.C., ELVEHJEM, C.A. and HART, E.B. (1941) Inositol in chick nutrition. Proceedings of the Society of Experimental Biological Medicine 47: 376-377.CrossRefGoogle Scholar
HOLUB, B.J. (1986) Metabolism and function of myo-inositol and inositol phospholipids. Annual Reviews of Nutrition 6: 563-597.CrossRefGoogle ScholarPubMed
HUYGHEBAERT, G., DE GROOTE, G. and GEERSE, C. (1992) Effect of microbial phytase on the utilization of phosphorus by broiler chickens. 1. Effect on the availability of phosphorus and calcium. Reviews in Agriculture 45: 217-228.Google Scholar
KARADAS, F., PIRGOZLIEV, V., PAPPAS, A.C., ACAMOVIC, T. and BEDFORD, M.R. (2010) Effects of different dietary phytase activities on the concentration of antioxidants in the liver of growing broilers. Journal of Animal Physiology and Animal Nutrition 94: 519-526.Google Scholar
KATAYAMA, T. (1997) Effect of dietary myo-inositol or phytic acid on heptatic concentrations of lipids and heptatic activities of lipogenic enzymes in rats fed on corn starch or sucrose. Nutrition Research 17: 721-728.CrossRefGoogle Scholar
KATAYAMA, T. (1999) Hypolipidemic action of phytic acid (IP6): prevention of fatty liver. Anticancer Research 19: 3695-3698.Google ScholarPubMed
KIES, A.K., KEMME, P.A., SEBEK, L.B.J., DIEPEN, J.T.M. and JONGBLOED, A.W. (2006) Effect of graded doses and a high dose of microbial phytase on the digestibility of various minerals in weaner pigs. Journal of Animal Science 84: 1169-1175.CrossRefGoogle Scholar
LANCE, B.G. and HOGAN, A.G. (1948) Vitamin B, inositol and nicotinic acid in the nutrition of the turkey. Journal of Nutrition 36: 369-379.CrossRefGoogle ScholarPubMed
LIU, N., RU, Y.J., LI, F.D. and COWIESON, A.J. (2008) Effect of diet containing phytate and phytase on the activity and messenger ribonucleic acid expression of carbohydrase and transporter in chickens. Journal of Animal Science 86: 3432-3439.CrossRefGoogle ScholarPubMed
LOTT, J.N.A., OCKENDEN, I., RABOY, V. and BATTEN, G.D. (2000) Phytic acid and phosphorus in crop seeds and fruits : a global estimate. Seed Science Research 10: 11-33.CrossRefGoogle Scholar
LUTTRELL, B.M. (1992) The biological relevance of the binding of calcium ions by inositol phosphates. The Journal of Biological Chemistry 268: 1521-1524.CrossRefGoogle Scholar
MAENZ, D.D. and CLASSEN, H.L. (1998) Phytase activity in the small intestinal brush border membrane of the chicken. Poultry Science 77: 557-563.CrossRefGoogle ScholarPubMed
McCOLLUM, E.V. and HART, E.B. (1908) On the occurrence of a phytin-splitting enzyme in animal tissues. The Journal of Biological Chemistry 4: 497-500.CrossRefGoogle Scholar
MIYAZAWA, E., IWABUCHI, A. and YOSHIDA, T. (1996) Phytate breakdown and apparent absorption of phosphorus, calcium and magnesium in germfree and conventionalised rats. Nutrition Research 16: 603-613.CrossRefGoogle Scholar
MOORE, R.J. and VEUM, T.L. (1983) Adaptive increase in phytate digestibility by phosphorus-deprived rats and the relationship of intestinal phytase (EC 3.1.3.8) and alkaline phosphatase (EC 3.1.3.1) to phytate utilization. British Journal of Nutrition 49: 145-152.CrossRefGoogle Scholar
MORSE, D., HEAD, H.H. and WILCOX, C.J. (1992) Disappearance of phosphorus in phytate from concentrates in vitro and from rations fed to lactating. Journal of Dairy Science 75: 1979-1986.CrossRefGoogle ScholarPubMed
MOTHES, R., SCHWENKE, K.D., ZIRWER, D. and GAST, K. (1990) Rapeseed protein - polyanion interactions. Soluble complexes between the 2 S protein fraction (napin) and phytic acid. Die Nahrung 34: 375-385.CrossRefGoogle Scholar
NAHAPETIAN, A. and YOUNG, V.R. (1980) Metabolism of C14-Phytate in rats: effect of low and high dietary calcium intakes. Journal of Nutrition 110: 1458-1472.CrossRefGoogle ScholarPubMed
NELSON, T.S. and KIRBY, L.K. (1987) The calcium-binding properties of natural phytate in chick diets. Nutrition Reports International 35: 949-956.Google Scholar
NELSON, T.S., SHIEH, T.R., WODZINSKI, R.J. and WARE, J.H. (1971) Effect of supplemental phytase on the utilization of phytate phosphorus by chicks. Journal of Nutrition 101: 1289-1294.CrossRefGoogle ScholarPubMed
NELSON, T.S. (1967) The utilization of phytate phosphorus by poultry – a review. Poultry Science 46: 862-871.CrossRefGoogle ScholarPubMed
ONYANGO, E.M., ASEM, E.K. and ADEOLA, O. (2008) Phytates reduce uptake of leucine and glutamate but not lysine and glucose from the intestinal lumen of chickens: short communication. Acta Veterinaria Hungarica 56: 511-514.CrossRefGoogle Scholar
OSHIMA, M., TAYLOR, T.G. and WILLIAMS, A. (1964) Variations in the concentration of phytic acid in the blood of the domestic fowl. Biochemistry 92: 42-46.Google ScholarPubMed
PEARCE, J. (1975) The effects of choline and inositol on hepatic lipid metabolism and the incidence of fatty liver and kidney syndrome in broilers. British Poultry Science 16: 565-570.CrossRefGoogle ScholarPubMed
PERSSON, H., TURK, M., NYMAN, M. and SANDBERG, A.-S. (1998) Binding of Cu2+, Zn2+ and Cd2+ to inositol tri-, tetra-, penta- and hexa-phosphates. Journal of Agriculture and Food Chemistry 46: 3194-3200.CrossRefGoogle Scholar
PETER, C.M., PARR, T.M., PARR, E.N., WEBEL, D.M. and BAKER, D.H. (2009) The effects of phytase on growth performance, carcass characteristics, and bone mineralization of late-finishing pigs fed maize-soyabean meal diets containing no supplemental phosphorus, zinc, copper and manganese. Animal Feed Science and Technology 94: 199-205.Google Scholar
PIRGOZLIEV, V., ODUGUWA, O., ACAMOVIC, T. and BEDFORD, M.R. (2007) Diets containing Escherichia coli-derived phytase on young chickens and turkeys: Effects on performance, metabolisable energy and endogenous secretions and intestinal morphology. Poultry Science 86: 705-713.CrossRefGoogle Scholar
SCHLEGEL, P., NYS, Y. and JONDREVILLE, C. (2009) Zinc availability and digestive zinc solubility in piglets and broilers fed diets varying in their phytate contents, phytase activity and supplemented zinc source. Animal 14: 200-209.Google Scholar
SCHLEMMER, U., JANY, K.-D., BERK, A., SCHULZ, E. and RECHKEMMER, G. (2001) Degradation of phytate in the gut of pigs - pathway of gastro-intestinal inositol phosphate hydrolysis and enzymes involved. Archives of Animal Nutrition 55: 255-280.Google ScholarPubMed
SHAN, A.S. and DAVIS, R.H. (1994) Effect of dietary phytate on growth and selenium status of chicks fed selenite or selenomethionine. British Poultry Science 35: 725-741.CrossRefGoogle ScholarPubMed
SHIRLEY, R.B. and EDWARDS, H.M. Jr (2003) Graded levels of phytase past industry standards improves broiler performance. Poultry Science 82: 671-680.CrossRefGoogle ScholarPubMed
SIMONS, P.C.M., VERSTEEGH, H.A.J., JONGBLOED, A.W., KEMME, P.A., SLUMP, P., BOS, K.D., WOLTERS, M.G.E., BEUDEKER, R.F. and VERSCHOOR, G.J. (1990) Improvement of phosphorous availability by microbial phytase in broilers and pigs. British Journal of Nutrition 64: 525-540.CrossRefGoogle ScholarPubMed
TAMIM, N.M. and ANGEL, R. (2003) Phytate phosphorus hydrolysis as influenced by dietary calcium and micromineral source in broiler diets. Journal of Agriculture and Food Chemistry 51: 4687-4693.CrossRefGoogle Scholar
TAMIM, N.M., ANGEL, R. and CHRISTMAN, M. (2004) Influence of dietary calcium and phytase on phytate phosphorus hydrolysis in broiler chickens. Poultry Science 83: 1358-1367.CrossRefGoogle ScholarPubMed
VERBSKY, J.W., WILSON, M.P., KISSELEVA, M.V., MAJERUS, P.W. and WENTE, S.R. (2002) The synthesis of inositol hexakisphosphate: characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase. The Journal of Biological Chemistry 277: 31857-31862.CrossRefGoogle ScholarPubMed
WOOLLEY, D.W. (1944) The nutritional significance of inositol. Journal of Nutrition 28: 305-314.CrossRefGoogle Scholar
WYSS, M., BRUGGER, R., KRONENBERGER, A., REMY, R., FIMBEL, R., OESTERHELT, G., LEHMANN, M. and VAN LOON, A.P.G.M. (1999) Biochemical characterization of fungal phytases (myo-Inositol hexakisphosphate phosphohydrolases): catalytic properties. Applied Environmental Microbiology 65: 367-373.CrossRefGoogle ScholarPubMed
ZHANG, Z.B., KORNEGAY, E.T., RADCLIFFE, J.S., DENBOW, D.M., VEIT, H.P. and LARSEN, C.T. (2000) Comparison of genetically engineered microbial and plant phytase for young broilers. Poultry Science 79: 709-717CrossRefGoogle ScholarPubMed