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Lycopene: a natural antioxidant for prevention of heat-induced oxidative stress in poultry

Published online by Cambridge University Press:  28 December 2017

M.A. ARAIN Open the ORCID record for M.A. ARAIN [Opens in a new window] ,
Z MEI ,
F.U. HASSAN ,
M. SAEED ,
M ALAGAWANY ,
A.H. SHAR  and
I.R. RAJPUT
M.A. ARAIN
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100 Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Balochistan, Pakistan 3800
Z MEI
Affiliation:
College of Science Shantou University, Shantou, Guangdong, P.R. China
F.U. HASSAN
Affiliation:
Institute of Animal and Dairy Sciences, Faculty of Animal Husbandry, University of Agriculture Faisalabad, Pakistan
M. SAEED
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100
M ALAGAWANY
Affiliation:
Poultry Department, Faculty of Agriculture, Zagazig University, 44511 Zagazig, Egypt
A.H. SHAR
Affiliation:
College of Life Sciences, Northwest A&F University, Yangling, 712100, China
I.R. RAJPUT*
Affiliation:
College of Science Shantou University, Shantou, Guangdong, P.R. China Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Balochistan, Pakistan 3800
*
Corresponding author: [email protected]
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Abstract

Heat stress is one of the most important physiological factors challenging poultry production throughout the world especially in tropical and sub-tropical countries. Oxidative stress induced by heat stress not only compromises productivity and performance but also results in morbidity and mortality losses leading to the economic burden for poultry producers. It reduces the shelf life of poultry product in addition to poor meat and egg quality. Recently, a trend towards using phytochemicals derived from natural sources with potential antioxidant activities has increased. Lycopene is a predominant carotenoid pigment which is universally found in fruits and vegetables, with tomatoes and their products being key sources. Several in vivo and in vitro studies have suggested that lycopene is a powerful antioxidant compared to other carotenoids. Supplementation of tomato (Solanum lycopersicum) derived lycopene revealed numerous health promoting activities in poultry birds, such as anti-oxidant, anti-inflammatory, immunomodulation, improved performance and better meat as well as egg quality. Lycopene maintains oxidative balance in birds through various ways including serving as a free radical scavenger, inhibiting signalling pathways and activating host antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT). The aims of this current review are to summarise mechanisms of action through which lycopene quench reactive species and maintain oxidative balance, highlight the potential role of lycopene as a natural antioxidant agent for poultry industry and examine the benefits to poultry producers when using this natural antioxidant on commercial basis in poultry diets to alleviate the adverse effects of heat stress.

Keywords

heat stresslycopeneantioxidantpoultryoxidative stress
Type
Reviews
Information
World's Poultry Science Journal , Volume 74 , Issue 1 , March 2018 , pp. 89 - 100
Copyright
Copyright © World's Poultry Science Association 2018 

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References

AENGWANICH, W. (2010) Pathological changes and the effects of ascorbic acid on lesion scores of bursa of fabricius in broilers under chronic heat stress. Comprehensive Therapy 1: 62-66.Google Scholar
AKBARIAN, A., MICHIELS, J., DEGROOTE, J., MAJDEDDIN, M., GOLIAN, A. and DE SMET, S. (2016) Association between heat stress and oxidative stress in poultry; mitochondrial dysfunction and dietary interventions with phytochemicals. Journal of Animal Science and Biotechnology 7: 1-14.Google Scholar
AKDEMIR, F., ORHAN, C., SAHIN, N., SAHIN, K. and HAYIRLI, A. (2012) Tomato powder in laying hen diets: Effects on concentrations of yolk carotenoids and lipid peroxidation. British Poultry Science 53: 675-680.CrossRefGoogle Scholar
ALTAN, O., PABUCCUOGLU, A., ALTAN, A., KONYALIOGLU, S. and BAYRAKTAR, H. (2003) Effect of heat stress on oxidative stress, lipid peroxidation and some stress parameters in broilers. British Poultry Science 44: 545-550.CrossRefGoogle Scholar
ANON (2012) Foods high in lycopene. http://www.dietandfitnesstoday.com/nutritioncontentsorted.php?nutid=337. Accessed 6 June 2012. Accessed on September 2017.Google Scholar
BARTLETT, J.R. and SMITH, M.O. (2003) Effects of different levels of zinc on the performance and immunocompetence of broilers under heat stress. Poultry Science 82: 1580-1588.Google Scholar
BLOKHINA, O., VIROLAINEN, E. and FAGERSTEDT, K.V. (2003) Antioxidants, oxidative damage and oxygen deprivation stress: A review. Annals of Botany 91: 179-194.Google Scholar
DAVIES, K.J. (1995) Oxidative stress: The paradox of aerobic life. Biochemical Society Symposium 61: 1-31.Google Scholar
DEATON, J.W., REECE, F.N., MCNAUGHTON, J.L. and LOTT, B.D. (1981) Effect of differing temperature cycles on egg shell quality and layer performance. Poultry Science 60: 733-737.CrossRefGoogle Scholar
DHAMA, K., LATHEEF, S.K., MANI, S., SAMAD, H.A., KARTHIK, K., TIWARI, R., KHAN, R.U., ALAGAWANY, M., FARAG, M.R., ALAM, G.M., LAUDADIO, V. and TUFARELLI, V. (2015) Multiple beneficial applications and modes of action of herbs in poultry health and production-a review. International Journal of Pharmacology 11: 152-176.Google Scholar
DOTAS, D., ZAMANIDIS, S. and BALIOS, J. (1999) Effect of dried tomato pulp on the performance and egg traits of laying hens. British Poultry Science 40: 695-697.Google Scholar
DROGE, W. (2002) Free radicals in the physiological control of cell function. Physiological Review 82: 47-95.Google Scholar
ENGLMAIEROVA, M., BUBANCOVA, I., VIT, T. and SKRIVAN, M. (2011) The effect of lycopene and vitamin e on growth performance, quality and oxidative stability of chicken leg meat. Czech Journal of Animal Science 56: 536-543.Google Scholar
FELVERGANT, J.N., MACK, L.A., DENNIS, R.L., EICHER, S.D. and CHENG, H.W. (2012) Genetic variations alter physiological responses following heat stress in 2 strains of laying hens. Poultry Science 91: 1542-1551.Google Scholar
GHAZI, S., HABIBIAN, M., MOEINI, M.M. and ABDOLMOHAMMADI, A.R. (2012) Effects of different levels of organic and inorganic chromium on growth performance and immunocompetence of broilers under heat stress. Biology of Trace Element Research 146: 309-317.Google Scholar
GORALCZYK, R. and SILER, U. (2003) The role of lycopene in health and disease, in: FENWICK, R. (Ed) Phytochemicals in health and disease, pp. 285-309 (Dekker, New York, NY).Google Scholar
GU, X.H., HAO, Y. and WANG, X.L. (2012) Overexpression of heat shock protein 70 and its relationship to intestine under acute heat stress in broilers: 2. Intestinal oxidative stress. Poultry Science 91: 790-799.Google Scholar
HABIBIAN, M., GHAZI, S., MOEINI, M.M. and ABDOLMOHAMMADI, A. (2014) Effects of dietary selenium and vitamin e on immune response and biological blood parameters of broilers reared under thermoneutral or heat stress conditions. International Journal of Biometeorology 58: 741-752.CrossRefGoogle Scholar
HALLIWELL, B. and WHITEMAN, M. (2004) Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean? British Journal of Pharmacology 142: 231.CrossRefGoogle Scholar
HEBER, D. and LU, Q.Y. (2002) Overview of mechanisms of action of lycopene. Experimental Biology and Medicine 227: 920-923.CrossRefGoogle Scholar
HOSSEINI-VASHAN, S.J., GOLIAN, A. and YAGHOBFAR, A. (2016) Growth, immune, antioxidant, and bone responses of heat stress-exposed broilers fed diets supplemented with tomato pomace. International Journal of Biometeorology 60: 1183-1192.Google Scholar
KARADAS, F., GRAMMENIDIS, E., SURAI, P.F., ACAMOVIC, T. and SPARKS, N.H. (2006) Effects of carotenoids from lucerne, marigold and tomato on egg yolk pigmentation and carotenoid composition. British Poultry Science 47: 561-566.CrossRefGoogle Scholar
LARA, L.J. and ROSTAGNO, M.H. (2013) Impact of heat stress on poultry production. Animals 3: 356-369.Google Scholar
LAURETANI, F., SEMBA, R.D., DAYHOFF-BRANNIGAN, M., CORSI, A.M., DI IORIO, A., BUIATTI, E., BANDINELLI, S., GURALNIK, J.M. and FERRUCCI, L. (2008) Low total plasma carotenoids are independent predictors of mortality among older persons - the inchianti study. European Journal of Nutrition 47: 335-340.CrossRefGoogle Scholar
LEAL, M., SHIMADA, A., RUIZ, F. and GONZALEZ DE MEJIA, E. (1999) Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by t-2 toxin in vivo. Toxicology Letters 109: 1-10.CrossRefGoogle Scholar
LIN, H., DECUYPERE, E. and BUYSE, J. (2006) Acute heat stress induces oxidative stress in broiler chickens. Comparative Biochemistry and Physiology A-Molecular and Integrative Physiology 144: 11-17.Google Scholar
LINGEN, C., ERNSTER, L. and LINDBERG, O. (1959) The promoting effect of lycopene on the non-specific resistance of animals. Experimental Cell Research 16: 384-393.Google Scholar
MARKETON, J.I.W. and GLASER, R. (2008) Stress hormones and immune function. Cellular Immunology 252: 16-26.Google Scholar
MARSDEN, A. and MORRIS, T.R. (1987) Quantitative review of the effects of environmental temperature on food intake, egg output and energy balance in laying pullets. British Poultry Science 28: 693-704.Google Scholar
MARTINEZ, A., RODRIGUEZ-GIRONES, M.A., BARBOSA, A. and COSTAS, M. (2008) Donator acceptor map for carotenoids, melatonin and vitamins. Journal of Physical Chemistry A 112: 9037-9042.CrossRefGoogle Scholar
MINVIELLE, F. (2009) What are quail good for in a chicken-focused world? World's Poultry Science Journal, 65: 601-608.Google Scholar
MUJAHID, A., AKIBA, Y. and TOYOMIZU, M. (2007) Acute heat stress induces oxidative stress and decreases adaptation in young white leghorn cockerels by downregulation of avian uncoupling protein. Poultry Science 86: 364-371.CrossRefGoogle Scholar
MUJAHID, A., YOSHIKI, Y., AKIBA, Y. and TOYOMIZU, M. (2005) Superoxide radical production in chicken skeletal muscle induced by acute heat stress. Poultry Science 84: 307-314.Google Scholar
NIU, Z.Y., LIU, F.Z., YAN, Q.L. and LI, W.C. (2009) Effects of different levels of vitamin e on growth performance and immune responses of broilers under heat stress. Poultry Science 88: 2101-2107.Google Scholar
OLSON, J.B., WARD, N.E. and KOUTSOS, E.A. (2008) Lycopene incorporation into egg yolk and effects on laying hen immune function. Poultry Science 87: 2573-2580.Google Scholar
ONO, H., NAKAO, N. and YOSHIMURA, T. (2009) Identification of the photoperiodic signalling pathway regulating seasonal reproduction using the functional genomics approach. General and Comparative Endocrinology 163: 2-6.CrossRefGoogle Scholar
PALOZZA, P., CATALANO, A., SIMONE, R. and CITTADINI, A. (2012a) Lycopene as a guardian of redox signalling. Acta Biochimica Polonica 59: 21-25.Google Scholar
PALOZZA, P., CATALANO, A., SIMONE, R.E., MELE, M.C. and CITTADINI, A. (2012b) Effect of lycopene and tomato products on cholesterol metabolism. Annals of Nutrition and Metabolism 61: 126-134.CrossRefGoogle Scholar
PALOZZA, P., PARRONE, N., SIMONE, R. and CATALANO, A. (2011) Role of lycopene in the control of ros-mediated cell growth: Implications in cancer prevention. Current Medical Chemistry 18: 1846-1860.Google Scholar
RAO, A.V. and AGARWAL, S. (1999) Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: A review. Nutrition Research 19: 305-323.Google Scholar
RENAUDEAU, D., COLLIN, A., YAHAV, S., DE BASILIO, V., GOURDINE, J.L. and COLLIER, R.J. (2012) Adaptation to hot climate and strategies to alleviate heat stress in livestock production. Animal 6: 707-728.Google Scholar
SAEED, M., ABD EL-HACK, M.E., ALAGAWANY, M., ARAIN, M.A., ARIF, M., MIRZA, M.A., NAVEED, M., CHAO, S., SARWAR, M., SAYAB, M. and DHAMA, K. (2017a) Chicory (cichorium intybus) herb: Chemical composition, pharmacology, nutritional and healthical applications. International Journal of Pharmacology 13: 351-360.CrossRefGoogle Scholar
SAEED, M., ABD ELHACK, M.E., ARIF, M., ELHINDAWY, M.M., ATTIA, A.I., MAHROSE, K.M., BASHIR, I., SIYAL, F.A., ARAIN, M.A. and FAZLANI, S.A. (2017b) Impacts of distiller's dried grains with solubles as replacement of soybean meal plus vitamin e supplementation on production, egg quality and blood chemistry of laying hens. Annals of Animal Science 17 (3): 849-862.Google Scholar
SAEED, M., ARAIN, M.A., ARIF, M., LAGAWANY, M., ABD EL-HACK, M.E., KAKAR, M.U., MANZOOR, R., ERDENEE, S. and CHAO, S. (2017c) Jatropha (Jatropha curcas) meal is an alternative protein source in poultry nutrition. World's Poultry Science Journal 73: 783-790.Google Scholar
SAEED, M., BABAZADEH, D., ARIF, M., ARAIN, M.A., BHUTTO, Z.A., SHAR, A.H., KAKAR, M.U., ANZOOR, R. and CHAO, S. (2017d) Silymarin: a potent hepatoprotective agent in poultry industry, World's Poultry Science Journal 73 (3): 483-492.Google Scholar
SAEED, M., BALOCH, A.R., WANG, M., SOOMRO, R.N., BALOCH, A.M., BUX, B.A., ARIAN, M.A., FARAZ, S.S. and ZAKRIYA, H.M. (2015) Use of cichorium intybus leaf extract as growth promoter, hepatoprotectant and immune modulent in broilers. Journal of Animal Production Advances 5: 585-591.Google Scholar
SAEED, M., NAVEED, M., ARAIN, M.A., ARIF, M., EL-HACK, M.E.A., ALAGAWANY, M., SIYAL, F.A., SOOMRO, R.N. and SUN, C. (2017e) Quercetin: Nutritional and beneficial effects in poultry. Worlds Poultry Science Journal 73: 355-364.Google Scholar
SAEED, M., XU, Y.T., REHMAN, Z.U., ARAIN, M.A., SOOMRO, R.N., ABD EL-HACK, M.E., BHUTTO, Z.A., ABBASI, B., DHAMA, K., SARWAR, M. and CHAO, S. (2017f) Nutritional and healthical aspects of yacon (smallanthus sonchifolius) for human, animals and poultry. International Journal of Pharmacology 13: 361-369.CrossRefGoogle Scholar
SAHIN, K., ONDERCI, M., SAHIN, N., GURSU, M.F. and KUCUK, O. (2003) Dietary vitamin C and folic acid supplementation ameliorates the detrimental effects of heat stress in Japanese quail. Journal of Nutrition 133:1882-1886.Google Scholar
SAHIN, K. (2015) Modulation of nf-κb and nrf2 pathways by lycopene supplementation in heat-stressed poultry. Worlds Poultry Science Journal 71: 271-284.Google Scholar
SAHIN, K., ONDERCI, M., SAHIN, N., GURSU, M.F., GURSU, M.F. and KUCUK, O. (2006a) Effects of lycopene supplementation on antioxidant status, oxidative stress, performance and carcass characteristics in heat-stressed japanese quail. Journal of Thermal Biology 31: 307-312.Google Scholar
SAHIN, N., SAHIN, K., ONDERCI, M., KARATEPE, M., SMITH, M.O. and KUCUK, O. (2006b) Effects of dietary lycopene and vitamin E on egg production, antioxidant status and cholesterol levels in Japanese quail. Asian Australasian Journal of Animal Sciences 19: 224-230.Google Scholar
SAHIN, K., ORHAN, C., AKDEMIR, F., TUZCU, M., ALI, S. and SAHIN, N. (2011) Tomato powder supplementation activates nrf-2 via erk/akt signalling pathway and attenuates heat stress-related responses in quails. Animal Feed Science and Technology 165: 230-237.Google Scholar
SAHIN, K., ORHAN, C., SMITH, M.O. and SAHIN, N. (2013a) Molecular targets of dietary phytochemicals for the alleviation of heat stress in poultry. Worlds Poultry Science Journal 69: 113-123.CrossRefGoogle Scholar
SAHIN, K., ORHAN, C., TUZCU, M. and SAHIN, N. (2013b) The Effects of lycopene on the meat lycopene levels, antioxidant enzymes and Nrf2 pathway in broiler chickens. 2nd International Poultry Meat Congress. 24-28 April 2013 Antalya, Turkey.Google Scholar
SAHIN, K., ORHAN, C., TUZCU, M., SAHIN, N., HAYIRLI, A., BILGILI, S. and KUCUK, O. (2016) Lycopene activates antioxidant enzymes and nuclear transcription factor systems in heat-stressed broilers. Poultry Science 95: 1088-1095.Google Scholar
SAHIN, K., OZERCAN, R., ONDERCI, M., SAHIN, N., KHACHIK, F., SEREN, S. and KUCUK, O. (2007) Dietary tomato powder supplementation in the prevention of leiomyoma of the oviduct in the japanese quail. Nutrition and Cancer 59: 70-75.Google Scholar
SAHIN, N., ORHAN, C., TUZCU, M., SAHIN, K. and KUCUK, O. (2008) The effects of tomato powder supplementation on performance and lipid peroxidation in quail. Poultry Science 87: 276-283.Google Scholar
SAHIN, N., SAHIN, K., ONDERCI, M., KARATEPE, M., SMITH, M.O. and KUCUK, O. (2006c) Effects of dietary lycopene and vitamin e on egg prodcution, antioxidant status and cholesterol levels in japanese quail. Asian Australasian Journal of Animal Sciences 19: 224-230.Google Scholar
SELIM, N.A., YOUSSEF, S.F., ABDEL-SALAM, A.F. and NADA, S.A. (2013) Evaluations of some natural antioxidant sources in broiler diets: 1-effect on growth, physiological and immunological performance of broiler chicks. International Journal of Poultry Science 12: 561-571.Google Scholar
SELYE, H. (1976) Forty years of stress research: Principal remaining problems and misconceptions. Canadian Medical Association Journal 115: 53-56.Google Scholar
ŠEVČÍKOVÁ, S. and SKŘIVAN, G.D. (2008) The effect of lycopene supplementation on lipid profile and meat quality of broiler chickens. Czech Journal of Animalence 53: 431-440.Google Scholar
SRIVASTAVA, S. and SRIVASTAVA, A.K. (2015) Lycopene; chemistry, biosynthesis, metabolism and degradation under various abiotic parameters. Journal of Food Science and Technology-Mysore 52: 41-53.Google Scholar
SUN, B., CHEN, C., WANG, W., MA, J., XIE, Q., GAO, Y., CHEN, F., ZHANG, X. and BI, Y. (2015) Effects of lycopene supplementation in both maternal and offspring diets on growth performance, antioxidant capacity and biochemical parameters in chicks. Journal of animal physiology and animal nutrition 99: 42-49.Google Scholar
SUN, B., MA, J., ZHANG, J., SU, L., XIE, Q., GAO, Y., ZHU, J., SHU, D. and BI, Y. (2014) Lycopene reduces the negative effects induced by lipopolysaccharide in breeding hens. British Poultry Science 55: 628-634.Google Scholar
SYAFWAN, S., KWAKKEL, R.P. and VERSTEGEN, M.W.A. (2011) Heat stress and feeding strategies in meat-type chickens. World's Poultry Science Journal 67: 653-673.Google Scholar
TANAKA, T., SHNIMIZU, M. and MORIWAKI, H. (2012) Cancer chemoprevention by carotenoids. Molecules 17: 3202-3242.Google Scholar
VAN BREEMEN, R.B. and PAJKOVIC, N. (2008) Multitargeted therapy of cancer by lycopene. Cancer Letter 269: 339-351.Google Scholar
VOGELE, A.C. (1937) Effect of environmental factors upon the color of the tomato and the watermelon. Plant Physiology 12: 929-955.Google Scholar
YAHAV, S. (2009) Alleviating heat stress in domestic fowl: Different strategies. World's Poultry Science Journal 65: 719-732.Google Scholar
YANNAKOPOULOS, A.L., TSERVENI-GOUSI, A.S. and CHRISTAKI, E.V. (1992) Effect of locally produced tomato meal on the performance and the egg quality of laying hens. Animal Feed Science & Technology 36: 53-57.CrossRefGoogle Scholar
ZHANG, J., HOU, X., AHMAD, H., ZHANG, H., ZHANG, L. and WANG, T. (2014) Assessment of free radicals scavenging activity of seven natural pigments and protective effects in aaph-challenged chicken erythrocytes. Food Chemistry 145: 57-65.CrossRefGoogle Scholar
ZULKIFLI, I., DUNNINGTON, E.A., GROSS, W.B. and SIEGEL, P.B. (1994) Inhibition of adrenal steroidogenesis, food restriction and acclimation to high ambient temperatures in chickens. British Poultry Science 35: 417-426.Google Scholar