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Every egg may have a targeted purpose: toward a differential approach to egg according to composition and functional effect

Published online by Cambridge University Press:  12 July 2010

N. SHAPIRA
N. SHAPIRA*
Affiliation:
Tel Aviv University, Stanley Steyer School of Health Professions, Tel Aviv, Israel
*
Corresponding author: [email protected]
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Abstract

Despite the suggested health advantages of traditionally- over industrially-produced western 'regular' eggs and the flexibility of egg composition, studies on the effects of egg intake refer mostly to quantity and lack qualitative information. The possibility of lending differential nutritional enhancement and functional advantages, i.e. vs. cardiovascular disease (CVD) or for perinatal health, could impact the current egg intake debate. N-3 polyunsaturated fatty acid (PUFA)/long-chain PUFA (LCPUFA) fortification of regular eggs by feeding extruded linseed (5%) yielded 3.8-fold higher total n-3 PUFA and 2.4-fold higher docosahexaenoic acid (DHA), with 3.6-fold lower n-6:n-3 PUFA ratio (p≤0.0005). This resulted in human dietary contributions of 10-20% of the n-3 PUFA Dietary Reference Intake (DRI) and 40% for DHA. Together with antioxidants, they may be beneficial against CVD risks as associated with oxidative stress, endothelial dysfunction, dyslipidemia, and inflammatory processes, especially in diabetics. Eggs fortified via poultry feed supplementation could attain higher %DRI for pregnancy or lactation for key nutrients, i.e. DHA (≈120- 130%), vitamins A (9.0-15.2%) and E (51.6-65.3%), iodine (15.2-20.1%), and selenium (33.7-39.3%). For infants aged 1-3 years, the improvement in %DRI for vitamins, minerals, and n-3 PUFA needed during peak brain development could be even higher. Compared to increased low-density lipoprotein (LDL) oxidation as seen with intake of two regular high n-6 PUFA eggs/day, eggs with reduced n-6 PUFA (by 40%), increased n-9 monounsaturated FA (MUFA) (by 30%), reduced PUFA:MUFA ratio (by 50%), and increased antioxidants vitamin E and carotenoids (by >200%), were associated with a 30% drop in LDL oxidisability (p<0.01), back to levels seen with a low-egg diet (2-4 eggs/week). Because egg composition is highly feed-dependent and closely affects plasma nutrients and lipoprotein composition and physiological qualities, it has much potential for imparting both nutritional and functional benefits. Poultry feeding could be carefully tailored for egg modification to address specific risks and requirements in consumers, warranting further research regarding differential effects and corresponding quantitative recommendations for egg intake, to maximise beneficial and preventative potential.

Keywords

eggn-3 PUFAn-9 MUFAantioxidantsperinatal nutritionCVD
Type
Review Article
Information
World's Poultry Science Journal , Volume 66 , Issue 2 , June 2010 , pp. 271 - 284
Copyright
World's Poultry Science Association 2010

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References

AMERICAN EGG BOARD (AEB), (2008) US Population, egg production and consumption 2004. http://www.aeb.org/egg-industry/industry-facts/egg-production-and-consumption.Google Scholar
ANDERSON, R.A., JONES, C.J. and GOODFELLOW, J. (2001) Is the fatty meal a trigger for acute coronary syndromes. Atherosclerosis 159: 9-15.CrossRefGoogle Scholar
AVIRAM, M. and EIAS, K. (1993) Dietary olive oil reduces low-density lipoprotein uptake by macrophages and decreases the susceptibility of the lipoprotein to undergo lipid peroxidation. Annals of Nutrition and Metabolism 37: 75-84.CrossRefGoogle ScholarPubMed
BARONI, S.S., AMELIO, M., SANGIORGI, Z., GADDI, A. and BATTINO, M. (1999) Solid monounsaturated diet lowers LDL unsaturation trait and oxidisability in hypercholesterolemic (type IIb) patients. Free Radical Research 30: 275-285.CrossRefGoogle ScholarPubMed
BHOMBAL, S., BOTHWELL, M.R. and BAUER, S.M. (2006) Prevalence of elevated total IgE and food allergies in a consecutive series of ENT pediatric patients. Otolaryngology, Head and Neck Surgery 134(4): 578-580.CrossRefGoogle Scholar
BOROD, E., ATKINSON, R., BARCLAY, W.R. and CARLSON, S.E. (1999) Effects of third trimester consumption of eggs high in docosahexaenoic acid on docosahexaenoic acid status and pregnancy. Lipids 34Suppl: S231.CrossRefGoogle ScholarPubMed
BOURRE, J.M. and GALEA, F. (2006) An important source of omega-3 fatty acids, vitamins D and E, carotenoids, iodine and selenium: a new natural multi-enriched egg. Journal of Nutrition in Health and Aging 10(5): 371-376.Google Scholar
BOURRE, J.M. (2005) New multi-enriched natural egg: exceptional nutrient content, especially in omega-3 fatty acids, vitamins, minerals and carotenoids. Medical Nutrition 41: 116-134.CrossRefGoogle Scholar
BOURRE, J.M. (2006a) Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. Journal of Nutrition in Health and Aging 10: 377-385.Google ScholarPubMed
BOURRE, J.M. (2006b) Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2: macronutrients. Journal of Nutrition in Health and Aging. 10: 386-399.Google ScholarPubMed
BRUCKNER, G. (1997) Microcirculation, vitamin E and omega 3 fatty acids: an overview. Advances in Experimental Medicine and Biology 415: 195-208.CrossRefGoogle ScholarPubMed
BURDGE, G.C. and CALDER, P.C. (2005) Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reproduction, Nutrition, Development 45: 581-597.CrossRefGoogle ScholarPubMed
CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC), (2006) Health, United States, with chartbook on trends in the health of Americans (Hyattsville, National Center for Health Statistics).Google Scholar
CHANCHARME, L., THEROND, P., NIGON, F., ZAREV, S., MALLET, A., BRUCKERT, E. and CHAPMAN, M.J. (2002) LDL particle subclasses in hypercholesterolemia. Molecular determinants of reduced lipid hydroperoxide stability. Journal of Lipid Research 43: 453-462.CrossRefGoogle ScholarPubMed
CRAWFORD, M.A. (2006) Docosahexaenoic acid in neural signaling systems. Nutrition and Health 18(3): 263-276.CrossRefGoogle ScholarPubMed
DE CATERINA, R., LIAO, J.K. and LIBBY, P. (2000) Fatty acid modulation of endothelial activation. American Journal of Clinical Nutrition 71(suppl 1): 213S-223S.CrossRefGoogle ScholarPubMed
DIMITRIADIS, E., GRIFFIN, M., COLLINS, P., JOHNSON, A., OWENS, D. and TOMKIN, G.H. (1996) Lipoprotein composition in NIDDM: effects of dietary oleic acid on the composition, oxidisability and function of low and high density lipoproteins. Diabetologia 39: 667-76.CrossRefGoogle ScholarPubMed
DJOUSSÉ, L. and GAZIANO, J.M. (2008) Egg consumption in relation to cardiovascular disease and mortality: the Physicians’ Health Study. American Journal of Clinical Nutrition 87(4): 964-969.CrossRefGoogle ScholarPubMed
DJOUSSÉ, L., GAZIANO, J.M., BURING, J.E. and LEE, I.M. (2009) Egg consumption and risk of type 2 diabetes in men and women. Diabetes Care 32(2): 295-300.CrossRefGoogle ScholarPubMed
DUBNOV, G. and BERRY, M.E. (2003) Omega-6/omega-3 fatty acid ratio: the Israeli paradox. World Reviews in Nutrition and Diet 92: 81-91.CrossRefGoogle ScholarPubMed
ENDEVELT, R. and SHAHAR, D.R. (2004) Omega-3: the vanishing nutrient beyond cardiovascular prevention and treatment. Israel Medical Association Journal 6: 2359.Google ScholarPubMed
ERVIN, R.B., WRIGHT, J.D., WANG, C. and KENNEDY-STEPHENSON, J. (2004) Advance data from vital and health statistics. Centers for Disease Control and Prevention (CDC), United States Department of Health and Human Services, National Center for Health Statistics 348: 1-7.Google Scholar
FORAN, J.A., GOOD, D.H., CARPENTER, D.O., HAMILTON, M.C., KNUTH, B.A. and SCHWAGER, S.J. (2005) Quantitative analysis of the benefits and risks of consuming farmed and wild salmon. Journal of Nutrition 135: 2639-2643.CrossRefGoogle ScholarPubMed
GOODE, G.K., GARCIA, S. and HEAGERTY, A.M. (1997) Dietary supplementation with marine fish oil improves in vitro small artery endothelial function in hypercholesterolemic patients: a double-blind placebo controlled study. Circulation 96: 2802-2807.CrossRefGoogle ScholarPubMed
GOODFELLOW, J., BELLAMY, M.F., RAMSEY, M.W., JONES, C.J. and LEWIS, M.J. (2000) Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. Journal of the American College of Cardiology 36: 265-270.CrossRefGoogle Scholar
GREENE, C.M., WATERS, D., CLARK, R.M., CONTOIS, J.H. and FERNANDEZ, M.L. (2006) Plasma LDL and HDL characteristics and carotenoid content are positively influenced by egg consumption in an elderly population. Nutrition and Metabolism (London) 3: 6.CrossRefGoogle Scholar
GRIFFIN, M.D., SANDERS, T.A., DAVIES, I.G., MORGAN, L.M., MILLWARD, D.J., LEWIS, F., SLAUGHTER, S., COOPER, J.A., MILLER, G.J. and GRIFFIN, B.A. (2006) Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. American Journal of Clinical Nutrition 84(6): 1290-1298.CrossRefGoogle ScholarPubMed
HARGROVE, R.L., ETHERTON, T.D., PEARSON, T.A., HARRISON, E.H. and KRIS-ETHERTON, P.M. (2001) Low fat and high monounsaturated fat diets decrease human low-density lipoprotein oxidative susceptibility in vitro. Journal of Nutrition 131: 1758-1763.CrossRefGoogle ScholarPubMed
HARRIS, W.S., MOZAFFARIAN, D., RIMM, E., KRIS-ETHERTON, P., RUDEL, L.L., APPEL, L.J., ENGLER, , M, M., ENGLER, M.B. and SACKS, F. (2009)Circulation 119(6): 902-907.CrossRefGoogle Scholar
HENNIG, B., TOBOREK, M. and MCCLAIN, J. (2001) High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. Journal of the American College of Nutrition 20(2 Suppl): 97-105.CrossRefGoogle ScholarPubMed
HU, F.B. and WILLETT, W.C. (2002) Optimal diets for prevention of coronary heart disease. Journal of the American Medical Association 288: 2569-2578.CrossRefGoogle ScholarPubMed
HU, F.B., STAMPFER, M.J., RIMM, E.B., MANSON, J.E., ASCHERIO, A., COLDITZ, G.A., ROSNER, B.A., SPIEGELMAN, D., SPEIZER, F.E., SACKS, F.M., HENNEKENS, C.H. and WILLETT, W.C. (1999) A prospective study of egg consumption and risk of cardiovascular disease in men and women. Journal of the American Medical Association 281(15): 1387-1394.CrossRefGoogle ScholarPubMed
INSTITUTES OF MEDICINE (IOM), (2002) Food and Nutrition Board. Dietary Reference Intakes. Washington D.C., National Academy Press.Google Scholar
ISRAEL CENTERS FOR DISEASE CONTROL (ICDC), (2003) MABAT. First Israeli National Health and Nutrition Survey 1999-2001. Part 1: General Findings, Publication No. 225.Google Scholar
ISRAEL CENTERS FOR DISEASE CONTROL (ICDC), (2004) MABAT. First Israeli National Health and Nutrition Survey 1999-2001. Part 2: What Israelis Eat, Publication No. 228.Google Scholar
JAMES, M.J., GIBSON, R.A. and CLELAND, L.G. (2000) Dietary polyunsaturated fatty acids and inflammatory mediator production. American Journal of Clinical Nutrition 71(1 Suppl): 343S-348S.CrossRefGoogle ScholarPubMed
JENKINS, D.J., SIEVENPIPER, J.L., PAULY, D., SUMAILA, U.R., KENDALL, C.W. and MOWAT, F.M. (2009) Are dietary recommendations for the use of fish oils sustainable? Canadian Medical Association Journal 180(6): 633-637.CrossRefGoogle ScholarPubMed
JIANG, Z. and SIM, J.S. (1993) Consumption of n-3 polyunsaturated fatty acid-enriched eggs and changes in plasma lipids of human subjects. Nutrition 9: 513-518.Google ScholarPubMed
KAPLAN, M. and AVIRAM, M. (1999) Oxidized low density lipoprotein: atherogenic and proinflammatory characteristics during macrophage foam cell formation. An inhibitory role for nutritional antioxidants and serum paraoxonase. Clinical Chemistry and Laboratory Medicine 37(8): 777-787.CrossRefGoogle ScholarPubMed
KNOPP, R.H. and PARAMSOTHY, P. (2006) Oxidized LDL and abdominal obesity: a key to understanding the metabolic syndrome. American Journal of Clinical Nutrition 83: 1-2.CrossRefGoogle ScholarPubMed
KRATZ, M., CULLEN, P., KANNENBERG, F., KASSNER, A., FOBKER, M., ABUJA, P.M., ASSMANN, G.M. and WAHRBURG, U. (2002) Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein. European Journal of Clinical Nutrition 56: 72-81.CrossRefGoogle ScholarPubMed
LEVY, Y., MAOR, I., PRESSER, D. and AVIRAMERICAN, M. (1996) Consumption of eggs with meals increases the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Annals of Nutrition Metabolism 40: 243-251.CrossRefGoogle ScholarPubMed
LEVY, Y., SHAPIRA, N., MAOR, I., PRESER, D., MOSHE, R. and AVIRAM, M. (1997) Is it possible to reduce LDL oxidizability in normolipidemic subjects by antioxidant and fat modification of egg? 11th International Symposium on Atherosclerosis, Paris.Google Scholar
LEWIS, N.M., SEBURG, S. and FLANAGAN, N.L. (2000) Enriched eggs as a source of N-3 polyunsaturated fatty acids for humans. Poultry Science 79: 971-974.CrossRefGoogle ScholarPubMed
MAKRIDES, M. and GIBSON, R.A. (2000) Long-chain polyunsaturated fatty acid requirements during pregnancy and lactation. American Journal of Clinical Nutrition 71(1 Suppl): 307S-311S.CrossRefGoogle ScholarPubMed
MAKRIDES, M., HAWKES, J.S., NEUMANN, M.A. and GIBSON, R.A. (2002) Nutritional effect of including egg yolk in the weaning diet of breast- and formula-fed infants: a randomized controlled trial. American Journal of Clinical Nutrition 75: 1084-1092.CrossRefGoogle ScholarPubMed
MATA, P., VARELA, O., ALONSO, R., LAHOZ, C., DE OYA, M. and BADIMON, L. (1997) Monounsaturated and polyunsaturated n-6 fatty acid-enriched diets modify LDL oxidation and decrease human coronary smooth muscle cell DNA synthesis. Arteriosclerosis, Thrombosis, and Vascular Biology 17: 2088-2095.CrossRefGoogle ScholarPubMed
MORI, T.A., WATTS, G.F., BURKE, V., HILME, E., PUDDEY, I.B. and BEILIN, J. (2000) Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation 102: 1264-1269.CrossRefGoogle ScholarPubMed
NETTLETON, J.A. ON BEHALF OF THE ALASKA SEAFOOD MARKETING INSTITUTE (ASMI) (2004) Increasing the consumption of long-chain ome-3 polyunsaturated fatty acids by Americans. Testimony to the Joint USDA/HHS 2005 Dietary Guidelines Advisory Committee.Google Scholar
NITSAN, Z., MOKADY, S. and SUKENIK, A. (1999) Enrichment of poultry products with omega3 fatty acids by dietary supplementation with the alga Nannochloropsis and mantur oil. Journal of Agriculture and Food Chemistry 47: 5127-5132.CrossRefGoogle ScholarPubMed
OHMAN, M., AKERFELDT, , T, , . NILSSON, I., ROSEN, C., HANSSON, L.O., CARLSSON, M. and LARSSON, A. (2008) Upsalla Journal of Medical Science 113(3): 315-323.CrossRefGoogle Scholar
OKEN, E., KLEINMAN, K.P., BERLAND, W.E., SIMON, S.R., RICH-EDWARDS J.W., and GILLMAN, M.W. (2003) Decline in fish consumption among pregnant women after a national mercury advisory. Obstetrics and Gynecology 102(2): 346-351.Google ScholarPubMed
OKUDA, , Y, , KAWASHIMA, K., SAWADA, T., TSURUMARU, K., ASANO, M., SUZUKI, S., SOMA, M., NAKAJIMA, T. and YAMASHITA, K. (1997) Eicosapentanoic acid enhances nitric oxide production by cultured human endothelial cells. Biochemical and Biophysical Research Communications 232: 487-491.CrossRefGoogle ScholarPubMed
PALMER, D.J. and MAKRIDES, M. (2006) Diet of lactating women and allergic reactions in their infants. Current Opinion in Clinical Nutrition and Metabolic Care 9(3): 284-288.CrossRefGoogle ScholarPubMed
PRENTICE, A., JARJOU, L.M., DRURY, P.J., DEWIT, O. and CRAWFORD, M.A. (1989) Breastmilk fatty acids of rural Gambian mothers: effects of diet and maternal parity. Journal of Pediatric Gastroenterology and Nutrition 8(4):486-490.Google ScholarPubMed
QURESHI, A.I., SURI, F.K., AHMED, S., NASA, A. DIVANI, A.A., and KIRMANI, J.F. (2007) Regular egg consumption does not increase the risk of stroke and cardiovascular disease. Medical Science Monitor2007 13: CR1-CR8.Google ScholarPubMed
REAVEN, P.D., GRASSE, B.J. and TRIBBLE, D.L. (1994) Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans. Arteriosclerosis, Thrombosis, and Vascular Biology 14: 557-566.CrossRefGoogle ScholarPubMed
REAVEN, P.D. and WITZTUM, J.L. (1996) Oxidized low-density lipoproteins in atherogenesis: role of dietary modification. Annual Reviews in Nutrition 16: 51-71.CrossRefGoogle ScholarPubMed
RIVELLESE, A.A., MAFFETTONE, A., VESSBY, B., UUSITUPA, M., HERMANSEN, K., BERGLUND, L., LOUHERANTA, A., MEYER, B.J. and RICCARDI, G.E. (2003) Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects. Atherosclerosis 167(1): 149-158CrossRefGoogle ScholarPubMed
SAUSENTHALER, S., KOLETZKO, S., SCHAAF, B., LEHMANN, I., BORTE, M., HERBARTH, O., VON BERG, A., WICHMANN, H.E. and HEINRICH, J. for the LISA STUDY GROUP (2007) Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age. American Journal of Clinical Nutrition 85(2): 530-537.CrossRefGoogle ScholarPubMed
SCHWAB, U.S., SARKKINEN, E.S., LICHTENSTEIN, A.H., LI, Z., ORDOVAS, J.M., SCHAEFER, E.J. and UUSITUPA, M.I. (1998) The effect of quality and amount of dietary fat on the susceptibility of low-density lipoprotein to oxidation in subjects with impaired glucose tolerance. European Journal of Clinical Nutrition 52: 452-458.CrossRefGoogle ScholarPubMed
SEO, T., BLANER, W.S. and DECKELBAUM, R.J. (2005) Omega-3 fatty acids: molecular approaches to optimal biological outcomes. Current Opinion in Lipidology 16: 11-18.CrossRefGoogle ScholarPubMed
SHAPIRA, N. (2009) Modified egg as a nutritional supplement during peak brain development: a new target for fortification. Nutrition and Health 20(2): 107-118.CrossRefGoogle ScholarPubMed
SHAPIRA, N. (2008) Egg composition vs. CVD risk: from wild-traditional to designer eggs vs. lipid, endothelial, and inflammatory hypotheses. II.5. In: Wild type food in health promotion and disease prevention: the Columbus concept (Totowa, Humana Press).CrossRefGoogle Scholar
SHAPIRA, N. and PINCHASOV, J. (2008) Modified egg composition to reduce low-density lipoprotein oxidizability: high monounsaturated fatty acids and antioxidants versus regular high n-6 polyunsaturated fatty acids. Journal of Agriculture and Food Chemistry 56(10): 3688-3693.CrossRefGoogle ScholarPubMed
SHAPIRA, N., WEILL, P. and LOEWENBACH, R. (2008) Egg fortification with n-3 polyunsaturated fatty acids (PUFA): nutritional benefits versus high n-6 PUFA western diets, and consumer acceptance. Israel Medical Association Journal 10(4): 262-265.Google ScholarPubMed
SHAPIRA, N. (2004) Mediterranean diet in the food chain: eggs vs. LDL oxidation, in: LAMBROU-PHILIPSON, C. & KONSTANTINIDIS, K. (Eds) Conference Publication: Mediet 2004, Traditional Mediterranean Diet: Past, Present and Future (Athens, Heliotopos).Google Scholar
SIMOPOULOS, A.P. (1999) New products from the agri-food industry: the return of n-3 fatty acids into the food supply. Lipids 34 Suppl: S297-S301.CrossRefGoogle ScholarPubMed
SIMOPOULOS, A.P. (2008) The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pacific Journal of Clinical Nutrition 17Suppl 1: 131-134.Google ScholarPubMed
SINGH, M. (2003) Nutrition, brain and environment: how to have smarter babies? Indian Pediatrics 40(3): 213-220.Google ScholarPubMed
SOSIN, E., BOROWIEC, F., STRZETELSKI, J. and SMULIKOWSKA, S. (2006) The effect of feeding regular or low a-linolenic acid linseed on the fatty acid composition of egg yolks. Journal of Animal Feed Science 15: 641-650.CrossRefGoogle Scholar
STEINBERG, D., PARTHASARATHY, S., CREW, T.E., KHOO, J.C. and WITZTUM, J.L. (1989) Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenecity. New England Journal of Medicine 320: 915-24.Google Scholar
STOCKER, R. and KEANEY, J.F. JR. (2004) Role of oxidative modifications in atherosclerosis. Physiology Reviews 84: 1381-1478.CrossRefGoogle ScholarPubMed
SURAI, P.F., MACPHERSON, A., SPEAKE, B.K. and SPARKS, N. (2000) Designer egg evaluation in a controlled trial. European Journal of Clinical Nutrition 54: 298-305.CrossRefGoogle ScholarPubMed
VANCE, G.H.S., LEWIS, S.A., GRIMSHAW, K.E.C., WOOD, P.J., BRIGGS, R.A., THORNTON, C.A. and WARNER, J.O. (2005) Exposure of the fetus and infant to hens' egg ovalbumin via the placenta and breast milk in relation to maternal intake of dietary egg. Clinical and Experimental Allergy 35(10): 1318-1326.CrossRefGoogle ScholarPubMed
WEAVER, K.L., IVESTER, P., CHILTON, J.A., WILSON, M.D., PANDEY, P. and CHILTON, F.H. (2008) The content of favorable and unfavorable polyunsaturated fatty acids found in commonly eaten fish. Journal of the American Diet Association 108(7): 1178-1185.CrossRefGoogle ScholarPubMed
WEILL, P., SCHMITT, B., CHESNEAU, G., DANIEL, N., SAFRAOU, F. and LEGRAND, P. (2002) Effects of introducing linseed in livestock diet on blood fatty acid composition of consumers of animal products. Annals of Nutrition and Metabolism 46: 182-191CrossRefGoogle ScholarPubMed
WEISMAN, D., MOTRO, M., SCHWAMMENTHAL, E., FISMAN, E.Z., TENENBAUM, A., TANNE, D. and ADLER, Y. (2004) Efficacy of omega-3 fatty acid supplementation in primary and secondary prevention of coronary heart disease. Israel Medical Association Journal 6: 227-232.Google ScholarPubMed
YAM, D., ELIRAZ, A. and BERRY, E.M. (1996) Diet and disease – the Israeli paradox: possible dangers of a high omega 6 polyunsaturated fatty acid diet. Israel Journal of Medical Science 32: 1134-1143.Google ScholarPubMed
YANNAKOPOULOS, A., TSERVENI-GOUSI, A. and CHRISTAKI, E. (2005) Enhanced egg production in practice: the case of bio-omega-3 egg. International Journal of Poultry Science 4: 531-535.Google Scholar