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Anti-aflatoxin activities of milk thistle (Silybum marianum) in broiler

Published online by Cambridge University Press:  31 July 2017

I.A. ALHIDARY ,
Z. REHMAN ,
R.U. KHAN  and
M. TAHIR
I.A. ALHIDARY*
Affiliation:
Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia
Z. REHMAN
Affiliation:
Faculty of Animal Husbandry & Veterinary Sciences, The University of Agriculture, Peshawar, Pakistan
R.U. KHAN
Affiliation:
Faculty of Animal Husbandry & Veterinary Sciences, The University of Agriculture, Peshawar, Pakistan
M. TAHIR
Affiliation:
Faculty of Animal Husbandry & Veterinary Sciences, The University of Agriculture, Peshawar, Pakistan
*
Corresponding author: [email protected]
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Abstract

Mycotoxins are secondary fungal metabolites of structurally diverse groups occurring worldwide as contaminants of cereals such as wheat, corn, maize, peanut, and barley, which comprise the main ingredients of poultry diets. Milk thistle (Silybum marianum) has wide range of beneficial properties, including data showing its positive effects in protecting the liver of birds exposed to aflatoxins. Trials have shown that in broilers affected by aflatoxicosis, which adversely affected feed intake, weight gain, feed efficiency, serum biochemistry and immune status, supplementation of diets with silymarin reduced the detrimental effects, thereby improving the productivity and health. Although promising results have been reported, established doses and further research on the standardisation of this herb will increase its uses as alternative to synthetic drugs. The following review discusses several important aspects of the beneficial properties of milk thistle on poultry growth performance in experimentally induced aflatoxicosis.

Keywords

aflatoxicosismilk thistleliverperformance
Type
Reviews
Information
World's Poultry Science Journal , Volume 73 , Issue 3 , September 2017 , pp. 559 - 566
Copyright
Copyright © World's Poultry Science Association 2017 

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References

ABOU-SHEHEMA, B.M., RAWIA, S.H, KHALIFAH, M.M. and ABDALLA, A.A. (2016) Effect of silymarin supplementation on the performance of developed chickens under summer condition 2-during laying period. Egyptian Poultry Science 36: 1233-1249.Google Scholar
ABUDABOS, A.M., ALYEMNI, A.H., DAFALLA, Y.M. and KHAN, R.U. (2017) Effect of organic acid blend and Bacillus subtilis alone or in combination on growth traits, blood biochemical and antioxidant status in broiler exposed to Salmonella typhimurium challenge during the starter phase. Journal of Applied Animal Research 45: 538-542.CrossRefGoogle Scholar
AHSAN, S., BHATTI, I.A., ASI, M.R., BHATTI, H.N. and SHEIKH, M.A. (2010) Occurrence of aflatoxins in maize grains from central areas of Punjab. International Journal of Agriculture and Biology 12: 571-575.Google Scholar
ALZAWQARI, M.H., AL-BADDANY, A.A., AL-BAADANI, H.H., ALHIDARY, I.A., KHAN, R.U., AQIL, G.M. and ABDURAB, A. (2016) Effect of feeding dried sweet orange (Citrus sinensis) peel and lemon grass (Cymbopogon citratus) leaves on growth performance, carcass traits, serum metabolites and antioxidant status in broiler during the finisher phase. Environmental Science and Pollution Research 23: 17077-17082.Google Scholar
ARAFA, A.S., BLOOMER, R.J., WILSON, H.R., SIMPSON, C.F. and HARMS, R.H. (1981) Susceptibility of various poultry species to dietary aflatoxin. British Poultry Science 22: 431-436.Google Scholar
ASIM, A., KHAN, K.N.M., CHEEMA, A.H., MIR, F.A. and AFZAL, M. (1990) Occurrence of aflatoxins in poultry liver and associated pathological changes. Pakistan Veterinary Journal 10: 51-54.Google Scholar
AMIRIDUMARI, H., SARIR, H., AFZALI, N. and FANIMAKKI, O. (2013) Effects of milk thistle seed against aflatoxin B1 in broiler model. Journal of Research in Medical Sciences 18:786-790.Google ScholarPubMed
BASAGA, H., POLI, G., TEKKAYA, C. and ARAS, I. (1997) Free radical scavenging and antioxidative properties of ‘silibin’ complexes on microsomal lipid per oxidation. Cell Biochemistry and Function 15: 27-33.Google Scholar
BAER-DUBOWSKA, W., SZAEFER, H. and KRAJKA-KUZNIAK, V. (1998) Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds. Xenobiotica 28: 735-743.Google Scholar
CHAND, N., DIN, M., DURRANI, F.R. and SAHIBZADA, S. (2011) Protective Effects of Milk Thistle (Silybum marianum) against Aflatoxin B1 in Broiler Chicks. Asian-Australasian Journal of Animal Sciences 24: 1011-1018.CrossRefGoogle Scholar
CHAKARVERTY, A. and PARSAD, J. (1991) Study on the effect of Milk Thistle extract on the performance of broiler chicks. Indian Poultry Advise 24: 37-38.Google Scholar
CHAND, N., MUHAMMAD, S., KHAN, R.U., ALHIDARY, I.A. and RAHMAN, Z.U. (2016) Ameliorative effect of synthetic γ-aminobutyric acid (GABA) on performance traits, antioxidant status and immune response in broiler exposed to cyclic heat stress. Environmental Science and Pollution Research 23: 23930-23935.Google Scholar
CHU, F.S. (1991) Mycotoxins Food contamination, mechanism, carcinogenic potential and preventive measures. Mutation Research 259: 291-306.Google Scholar
DENLI, M. and OKAN, F. (2006) Efficacy of different adsorbents in reducing the toxic effects of aflatoxin B1 in broiler diets. South African Journal of Animal Science 36: 222-228 Google Scholar
DUMARI, M.A., SARIR, H., MAKKI, O.F. and AFZALI, N. (2014) Effect of milk thistle (Silybum marianumL.) on biochemical parameters and immunity of broiler chicks fed Aflatoxin B1 after three weeks. Iranian Journal of Toxicology 8: 1098-1103.Google Scholar
ELLIS, W.O., SMITH, J.P., SIMPSON, B.K. and OLDHAM, J.H. (1991) Aflatoxin in food: Occurrence, biosynthesis, effects on organisms, detection and methods of control. Critical reviews in food science and nutrition 30: 403-439.Google Scholar
FAULSTICH, H., JAHN, W. and WIELAND, T. (1980) Silybin inhibition of amatoxin uptake in Ne perfuse rat liver. Drug Research 30 3: 452-454.Google Scholar
FRASCHINI, F., DEMARTINI, G. and ESPOSTI, D. (2002) Pharmacology of silymarin. Clinical Drug Investigation 22: 51-65.Google Scholar
GAZAK, R., WALTEROVA, D. and KREN, V. (2007) Silybin and Silymarin-New and emerging applications in medicine. Current Medicinal Chemistry 14: 1-24.Google Scholar
GOWDA, S.K. and SASTRY, V.R.B. (2000) Neem (Azadirachta indica) seed cake in animal feeding-scope and limitation- Review. Asian-Australasian Journal of Animal Sciences 13: 720-728.CrossRefGoogle Scholar
HUSSAIN, Z., KHAN, M.Z. and HASSAN, Z.U. (2008) Production of aflatoxins from aspergillus flavus and acute aflatoxicosis in young broiler chicks. Pakistan Journal of Agricultural Sciences 45: 95-102.Google Scholar
HUSSEIN, H.S. and BRASEL, J.M. (2001) Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 167:101-34.Google Scholar
INDRESH, H., DEVEGOWDA, G., RUBAN, S.W. and SHIVAKUMAR, M.C. (2013) Effects of high grade bentonite on performance, organ weights and serum biochemistry during aflatoxicosis in broilers. Veterinary World 6: 313-317.Google Scholar
JAHANIAN, E., MAHDAVI, A.H., ASGARY, S. and JAHANIAN, R. (2017) Effects of dietary inclusion of silymarin on performance, intestinal morphology and ileal bacterial count in aflatoxin-challenged broiler chicks. Journal of Animal Physiology and Animal Nutrition: DOI: 10.1111/jpn.12556.CrossRefGoogle Scholar
KALOREY, D.R., KURKURE, N.V., RAMGAONKAR, I.S., SAKHARE, P.S., WARKE, S. and NIGOT, N.K. (2005) Effect of polyherbal feed supplement “Growell” during induced aflatoxicosis, ochratoxicosis and combined mycotoxicoses in broilers. Asian-Australasian Journal of Animal Sciences 18: 375-383.CrossRefGoogle Scholar
KECECI, T., OGUZ, H., KURTOGLU, V. and DEMET, O. (1998) Effects of polyvinylpolypyrrolidone, synthetic zeolite, and bentonite on serum biochemical and hematological characters of broiler chickens during aflatoxicosis. British Poultry Science 39: 452-458.Google Scholar
KOSINA, P., KREN, V., GEBHARDT, R., GRAMBAL, F., ULRICHOVA, J. and WALTEROVA, D. (2002) Antioxidant properties of silybin glycosides. Phytotherapy Research 16: S33-S39.Google Scholar
LUDOVICO, A., CAPASSO, R., MILIC, N. and CAPASSO, F. (2010) Milk thistle in liver diseases: past, present, future. Phytotherapy Research 24: 1423-1432.Google Scholar
MADHESWARAN, R., BALACHANDRAN, C. and MURALI MANOHAR, B. (2004) Influence of dietary culture material containing aflatoxin and T (2) toxin on certain serum biochemical constituents in Japanese quail. Mycopathologia 158: 337-341.CrossRefGoogle Scholar
MALEKINEJAD, P., AFZALI, N., MOHAMMADI, A. and SARIR, H. (2015) Protective effects of milk thistle (silybum marianum) seeds and sodium bentonite in ameliorating the toxic effects of aflatoxin b1 in broiler chicks. Archives of Medical Laboratory Sciences 1: 67-73.Google Scholar
MATUR, E., ERGUL, E., AKYAZI, I., ERASLAN, E. and CIRAKLI, Z.T. (2010) The effects of Saccharomyces cerevisiae extract on the weight of some organs, liver, and pancreatic digestive enzyme activity in breeder hens fed diets contaminated with aflatoxins. Poultry Science 89: 2213-2220.CrossRefGoogle ScholarPubMed
MIGUEZ, M.P., ANUNDI, I., SAINZ-PARDO, L.A. and LINDROS, K.O. (1994) Hepatoprotective mechanism of silymarin; no evidence for involvement of cytochrome P450 2E1. Chemico-Biological Interactions 91: 51-63.Google Scholar
MOROVAT, M., CHAMANI, M., ZAREI, A. and SADEGHI, A.A. (2016) Dietary but not in ovo feeding of Silybum marianum extract resulted in an improvement in performance, immunity and carcass characteristics and decreased the adverse effects of high temperatures in broilers, British Poultry Science 57: 105-113.Google Scholar
MUHAMMAD, D., CHAND, N., KHAN, S., SULTAN, A., MUSHTAQ, M. and RAFIULLAH, (2012) Hepatoprotective role of milk thistle (Silybum Marianum) in meat type chicken fed aflatoxin B1 contaminated feed. Pakistan Veterinary Journal 32: 443-446.Google Scholar
MURIEL, P. and MOURELLE, M. (1990) Prevention by silymarin of membrane alterations in acute CCL4 liver damage. Journal of Applied Toxicology 10: 275-279.CrossRefGoogle ScholarPubMed
MUNTER, K., MAYER, D. and FAULSTICH, H. (1986) Characterisation of a transporting system in rat hepatocytes: studies with competitive and non-competitive inhibitors of phalloidin transport. Biochimica et Biophysica Acta 860: 91-98.CrossRefGoogle ScholarPubMed
OGUZ, H., KECECI, T., BIRDANE, Y.O., ONDER, F. and KURTOGLU, V. (2000) Effect of clinoptilolite on serum biochemical and hematological characters of broiler chickens during experimental aflatoxicosis. Research in Veterinary Science 69: 89-93.Google Scholar
OMID, F.M., OMID, A., AFZALI, N., SARI, H., FROUZANMEHR, M. and SHIBAK, A. (2014) Efficacy of silybum marianum seeds in ameliorating the toxic effects of aflatoxin B1 in broilers. Iranian Journal of Toxicology 8: 977-982.Google Scholar
OMID, F.M., AFZALI, N. and OMIDI, A. (2013) Effect of different levels of Silymarin (Silybum marianum) on growth rate, carcass variables and liver morphology of broiler chickens contaminated with aflatoxin B1. Poultry Science Journal 1: 105-116.Google Scholar
PIVA, G., GALVANO, F., PIETRI, A. and PIVA, A. (1995) Detoxification methods of aflatoxins. A review. Nutrition Research 15: 767-776.CrossRefGoogle Scholar
PRADHAN, S.C. and GIRISH, C. (2006) Hepato protective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian Journal of Medical Research 124: 491-504.Google Scholar
SABRI, M.A., SIDDIQUE, M., KHAN, M.Z. and SAMAD, H.A. (1989) Prevalence and pathology of mycotoxicosis in young broiler chicks in and around Faisalabad. Pakistan Veterinary Journal 9: 106-108.Google Scholar
SALIOU, C., RIHN, B., CILLARD, J., OKAMOTO, T. and PACKER, L. (1998) Selective inhibition of NF-κB activation by the flavonoid hepatoprotector silymarin in HepG2. FEBS Letters 440: 8-12.Google Scholar
SALLER, R., MEIER, R. and BRIGNOLI, R. (2001) The use silymarin in the treatment of liver diseases. Drugs 61: 2035-2063.Google Scholar
SANTURIO, J.M., MALLMANN, C.A., ROSA, A.P., APPEL, G., HEER, A. and DAGEFÖRDE, S. (1999) Effect of sodium bentonite on the performance and blood variables of broiler chickens intoxicated with aflatoxin. British Poultry Science 40:115-119.Google Scholar
SONNENBICHLER, J. and ZETL, I. (1986) Biochemical effects of the flavonolignane silibinin on RNA, protein and DNA synthesis in rat livers. Progress in Clinical and Biological Research 213: 319-331.Google ScholarPubMed
SURAI, P.F. (2015) Silymarin as a natural antioxidant: an overview of the current evidence and perspectives. Antioxidants 4: 204-247.Google Scholar
THYAGARAJAN, S., JAYARAM, S., GOPALAKRISHNAN, V., HARI, R., JEYAKUMAR, P. and SRIPATHI, M. (2002) Herbal medicines for liver diseases in India. Journal of Gastroenterology and Hepatology 17: S370-S376.Google Scholar
TEDESCO, D., DOMENEGHINI, C., SCIANNIMANICO, D., TAMENI, M., STEIDLER, S. and GALLETTI, S. (2004) Efficacy of silymarin phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks. Poultry Science 83: 1839-1843.CrossRefGoogle ScholarPubMed
WISEMANN, H. (1996) dietary influences on membrane function: Importance in protection against oxidative damage and disease. The Journal of Nutritional Biochemistry 7: 2-5.Google Scholar
WILASRUSMEE, C., KITTUR, S., SHAH, G., SIDDIQUI, J., BRUCH, D., WILASRUSMEE, S. and KITTUR, D.S. (2002) Immunostimulatory effect of Silybum marianum (Milk Thistle) extract. Medical Science Monitor 8: 439-443.Google Scholar
YUNUS, A.W., RAZZAZI-FAZELI, E. and BOHM, J. (2011) Aflatoxin B1 in affecting broiler's performance, immunity, and gastrointestinal tract: A review of history and contemporary issues. Toxins 3: 566-590.Google Scholar
YUNUS, A., NASIR, M., FAROOQ, U. and BÖHM, J. (2008) Prevalence of poultry diseases and their interaction with mycotoxicosis in district Chakwal: 1. Effects of age and flock size. Journa of Animal and Plant Sciences 18: 107-113.Google Scholar
ZAHID, R. and DURRANI, F.R. (2007) Biochemical, hematological, immunological and growth promotant role of feed added Milk Thistle (Silybum marianum) in broiler chicks. M.Sc (Hons) thesis submitted to NWFP Agric. Univ. Peshawar, Pakistan.Google Scholar