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Silymarin: a potent hepatoprotective agent in poultry industry

Published online by Cambridge University Press:  18 August 2017

M. SAEED ,
D. BABAZADEH ,
M. ARIF ,
M.A. ARAIN ,
Z.A. BHUTTO ,
A.H. SHAR ,
M.U. KAKAR ,
R. MANZOOR  and
S. CHAO
M. SAEED
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100
D. BABAZADEH
Affiliation:
Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
M. ARIF
Affiliation:
Department of Animal Sciences, University College of Agriculture, University of Sargodha, 40100, Pakistan
M.A. ARAIN
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100 Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, 3800, Uthal, Balochistan, Pakistan
Z.A. BHUTTO
Affiliation:
Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, 3800, Uthal, Balochistan, Pakistan
A.H. SHAR
Affiliation:
College of Life Sciences, Northwest A&F University, Yangling, 712100, China
M.U. KAKAR
Affiliation:
Faculty of Marine Sciences, Lasbela university of Agriculture, Water and Marine Sciences, Uthal, Balochistan, Pakistan3800
R. MANZOOR
Affiliation:
Faculty of Marine Sciences, Lasbela university of Agriculture, Water and Marine Sciences, Uthal, Balochistan, Pakistan3800
S. CHAO*
Affiliation:
Department of Animal Nutrition, College of Animal Sciences and Technology, Northwest A&F University, Yangling, China, 712100
*
Corresponding author: [email protected]
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Abstract

Silymarin is composed of flavonolignans and derived from the dry seed of milk thistle (Silybummarianum) herb. It is used as a hepatoprotective treatment for different liver ailments, mainly cirrhosis, jaundice, growth promotant, alcoholic liver disease, chronic hepatitis C, chronic liver diseases and hepatocellular carcinoma. Reported medicinal properties are anti-inflammatory, immunomodulating, anti-diabetic, antioxidant, low toxicity, promising pharmacokinetics, protective, preventive, regenerative and antifibrotic effects and has been shown to be extremely safe. The mode of action by which silymarin might protect liver cells includes stabilisation of membranes, free radical scavenging, stimulation of hepatocyte protein synthesis and modulation of the immune response. In addition, silymarin can be used to treat jaundice disorders by ameliorating the levels of various hepatic enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Moreover, silymarin is able to moderate the immune system, by boosting IL-4, IFN-γ, and IL-10. The hepatoprotective effect of silymarin in poultry farming is poorly understood, although it may be used as a cheap, non-toxic and safe feed additive to manage liver related disorders and to replace synthetic drugs in poultry diets. Hence, this review will allow scientists, veterinarians, researchers, poultry producers to gain a pragmatic edge as well as perspective usage of Silymarin. A main priority is in finding the effective level in poultry whereby it acts as a natural liver tonic in the poultry industry and could reduce veterinary expenses.

Keywords

hepatoprotectivehepatic enzymesmilk thistlepoultrysilymarin
Type
Reviews
Information
World's Poultry Science Journal , Volume 73 , Issue 3 , September 2017 , pp. 483 - 492
Copyright
Copyright © World's Poultry Science Association 2017 

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