Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-23T14:26:44.372Z Has data issue: false hasContentIssue false

Progress in Chlamydia psittaci vaccine development in poultry

Published online by Cambridge University Press:  31 July 2017

A.M.M. QUILICOT
Affiliation:
Department of Poultry Diseases with Clinic, Faculty of Veterinary Medicine, University of Zagreb, Croatia College of Veterinary Medicine, Visayas State University, ViSCA, Baybay City 6521-A Leyte, Philippines
Ž. GOTTSTEIN*
Affiliation:
Department of Poultry Diseases with Clinic, Faculty of Veterinary Medicine, University of Zagreb, Croatia
D. HORVATEK TOMIĆ
Affiliation:
Department of Poultry Diseases with Clinic, Faculty of Veterinary Medicine, University of Zagreb, Croatia
E. PRUKNER-RADOVČIĆ
Affiliation:
Department of Poultry Diseases with Clinic, Faculty of Veterinary Medicine, University of Zagreb, Croatia
*
Corresponding author: [email protected]
Get access

Abstract

Chlamydia psittaci, depending on its serovar, can infect humans, birds, and other animals and livestock. Its economic impact on poultry production, especially on turkeys and chickens, and potential zoonotic risk have driven the search for an effective vaccination protocol to prevent and control the infection and shedding of the organism. Currently, no vaccine is approved for use against avian chlamydiosis despite efforts in the past decades. The present genomic era presents an opportunity to establish an effective vaccination scheme, taking advantage of the major outer membrane protein (MOMP) as the major protective antigen of C. psittaci. The plasmid DNA expressing MOMP can be coupled with optimisation of controllable factors during vaccination such as codon optimisation (through formation of polyplexes and lipoplexes), route of administration, vaccination schedule, addition of adjuvants/co-stimulatory factors such as cytokines and CpG motifs, and recombination with other poultry pathogens such as viruses. The development of an effective vaccine against C. psittaci will protect susceptible poultry from infection and production performance losses and reduce the zoonotic risk and minimise the emergence of antibiotic-resistant C. psittaci strains.

Type
Reviews
Copyright
Copyright © World's Poultry Science Association 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

ANDERSEN, A.A. and VANROMPAY, D. (2000) Avian chlamydiosis. Revue Scientifique Et Technique De L'Office International Des Epizooties 19: 396-404.Google Scholar
BEECKMAN, D.S.A. and VANROMPAY, D.C.G. (2009) Zoonotic Chlamydophila psittaci infections from a clinical perspective. Clinical Microbiology and Infection 15: 11-17.Google Scholar
BRUNHAM, R.C., ZHANG, D.J., YANG, X. and MCCLARTY, G.M. (2000) The potential for vaccine development against chlamydial infection and disease. Journal of Infectious Diseases 181: 538-543.Google Scholar
DUNHAM, S.P. (2002) The application of nucleic acid vaccines in veterinary medicine. Research in Veterinary Science 73: 9-16.CrossRefGoogle ScholarPubMed
EKO, F.O., HE, Q., BROWN, T., MCMILLAN, L., IFERE, G.O., ANANABA, G.A., LYN, D., LUBITZ, W., KELLAR, K.L., BLACK, C.M. and IGIETSEME, J.U. (2004) A novel recombinant multisubunit vaccine against Chlamydia . The Journal of Immunology 173: 3375-3382.Google Scholar
GAEDE, W., RECKLING, K.-F., DRESENKAMP, B., KENKLIES, S., SCHUBERT, E., NOACK, U., IRMSCHER, H.-M., LUDWIG, C., HOTZEL, H. and SACHSE, K. (2008) Chlamydophila psittaci infections in humans during an outbreak of psittacosis from poultry in Germany. Zoonoses and Public Health 55: 184-188.CrossRefGoogle ScholarPubMed
GRANDI, G. (2001) Antibacterial vaccine design using genomics and proteomics. Trends in Biotechnology 19: 181-188.Google Scholar
HE, C., LI, S., YANG, L., HE, G., LIU, W. and YAO, B. (2007) Induction of a protective immune response against Chlamydophila psittaci in SPF chicken following vaccination with Omp-1 DNA and CpG oligonucleotides as an adjuvant. Bulletin-Veterinary Institute in Pulawy 51: 351.Google Scholar
IGIETSEME, J.U. and BLACK, C.M. (2013) Chlamydia vaccine development, in: BLACK, C.M. (Ed) Chlamydial Infection: A Clinical and Public Health Perspective, Vol. 7, pp. 115-130 (Basel, Switzerland, Karger Publishers).Google Scholar
KAISER, P. (2010) Advances in avian immunology—prospects for disease control: a review. Avian Pathology 39: 309-324.Google Scholar
KNITTLER, M.R. and SACHSE, K. (2015) Chlamydia psittaci: update on an underestimated zoonotic agent. Pathogens and Disease 73: 1-15.CrossRefGoogle Scholar
LAGAE, S. and VANROMPAY, D. (2015) Innate immune response in avian macrophages elicited by Chlamydia psittaci . Vlaams Diergeneeskundig Tijdschrift 84: 133-141.Google Scholar
LIU, S., SUN, W., CHU, J., HUANG, X., WU, Z., YAN, M., ZHANG, Q., ZHAO, P., IGIETSEME, J.U., BLACK, C.M., HE, C. and LI, Y. (2015) Construction of recombinant HVT expressing PmpD, and immunological evaluation against Chlamydia psittaci and Marek's disease virus. PLOS ONE 10: 1-16.Google Scholar
LONGBOTTOM, D. (2003) Chlamydial vaccine development. Journal of Medical Microbiology 52: 537-540.CrossRefGoogle ScholarPubMed
LOOTS, K., LOOCK, M.V., VANROMPAY, D. and GODDEERIS, B.M. (2006) CpG motifs as adjuvant in DNA vaccination against Chlamydophila psittaci in turkeys. Vaccine 24: 4598-4601.Google Scholar
OSHOP, G.L., ELANKUMARAN, S. and HECKERT, R.A. (2002) DNA vaccination in the avian. Veterinary Immunology and Immunopathology 89: 1-12.Google Scholar
QIU, C., ZHOU, J., CAO, X., LIN, G., ZHENG, F. and GONG, X. (2010) Immunisation trials with an avian chlamydial MOMP gene recombinant adenovirus. Bioengineered Bugs 1: 269-275.Google Scholar
RADOMSKI, N., EINENKEL, R., MÜLLER, A. and KNITTLER, M.R. (2016) Chlamydia-host cell interaction not only from a bird's eye view: some lessons from Chlamydia psittaci . FEBS Letters 590: 3920-3940.Google Scholar
RAPPUOLI, R., BLACK, S. and LAMBERT, P.H. (2011) Vaccine discovery and translation of new vaccine technology. The Lancet 378: 360-368.Google Scholar
SACHSE, K., LAROUCAU, K. and VANROMPAY, D. (2015) Avian chlamydiosis. Current Clinical Microbiology Reports 2: 10-21.Google Scholar
SCARSELLI, M., GIULIANI, M.M., ADU-BOBIE, J., PIZZA, M. and RAPPUOLI, R. (2005) The impact of genomics on vaccine design. Trends in Biotechnology 23: 84-91.Google Scholar
SERRUTO, D. and RAPPUOLI, R. (2006) Post-genomic vaccine development. FEBS Letters 580: 2985-2992.Google Scholar
SETTE, A. and RAPPUOLI, R. (2010) Reverse Vaccinology: Developing vaccines in the era of genomics. Immunity 33: 530-541.Google Scholar
SINGH, M. and O'HAGAN, D.T. (2003) Recent advances in veterinary vaccine adjuvants. International Journal for Parasitology 33: 469-478.Google Scholar
VAN DRUNEN LITTEL-VAN DEN HURK, S., GERDTS, V., LOEHR, B.I., PONTAROLLO, R., RANKIN, R., UWIERA, R. and BABIUK, L.A. (2000) Recent advances in the use of DNA vaccines for the treatment of diseases of farmed animals. Advanced Drug Delivery Reviews 43: 13-28.Google Scholar
VANROMPAY, D., COX, E., KAISER, P., LAWSON, S., VAN LOOCK, M., VOLCKAERT, G. and GODDEERIS, B. (2001) Protection of turkeys against Chlamydophila psittaci challenge by parenteral and mucosal inoculations and the effect of turkey interferon-γ on genetic immunisation. Immunology 103: 106-112.Google Scholar
VANROMPAY, D., COX, E., VANDENBUSSCHE, F., VOLCKAERT, G. and GODDEERIS, B. (1999a) Protection of turkeys against Chlamydia psittaci challenge by gene gun-based DNA immunisations. Vaccine 17: 2628-2635.Google Scholar
VANROMPAY, D., COX, E., VOLCKAERT, G. and GODDEERIS, B. (1999b) Turkeys are protected from infection with Chlamydia psittaci by plasmid DNA vaccination against the major outer membrane protein. Clinical and Experimental Immunology 118: 49-55.Google Scholar
VANROMPAY, D., HARKINEZHAD, T., VAN DE WALLE, M., BEECKMAN, D., van DROOGENBROECK, C., VERMINNEN, K., LETEN, R., MARTEL, A. and CAUWERTS, K. (2007) Chlamydophila psittaci transmission from pet birds to humans. Emerging Infectious Disease 13: 1108-1110.Google Scholar
VERMINNEN, K., BEECKMAN, D.S.A., SANDERS, N.N., DE SMEDT, S. and VANROMPAY, D.C.G. (2010) Vaccination of turkeys against Chlamydophila psittaci through optimised DNA formulation and administration. Vaccine 28: 3095-3105.CrossRefGoogle ScholarPubMed
WYRICK, P.B. (2000) Intracellular survival by Chlamydia . Cellular Microbiology 2: 275-282.Google Scholar