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Dietary arginine: metabolic, environmental, immunological and physiological interrelationships

Published online by Cambridge University Press:  17 December 2010

F. KHAJALI  and
R.F. WIDEMAN
F. KHAJALI*
Affiliation:
Department of Animal Science, Shahrekord University, Shahrekord, Iran
R.F. WIDEMAN
Affiliation:
Center of Excellence for Poultry Science, University of Arkansas, Fayetteville AR 72703, USA
*
Corresponding author: [email protected]; [email protected]
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Abstract

Arginine is an essential amino acid for chickens due to the absence of a functional urea cycle in birds. Arginine plays critical roles in metabolic pathways associated with growth and immune-competence. Likewise, as a precursor of nitric oxide synthesis, arginine is important as the key vasodilator that opposes the onset of pulmonary hypertension in broiler (meat-type) chickens. Dietary arginine levels in commercial broiler diets meet NRC recommendations. However, this review shows that NRC recommendations may not be adequate to support maximal growth, support arginine-depleting immune responses, and prevent the onset of pulmonary hypertension in broilers reared under rigorous environmental conditions. Dietary composition is highly important and broiler performance may suffer when insufficient levels of arginine are included in the diet. Fortification of broiler diets with supplemental arginine may be necessary under such circumstances.

Keywords

arginineimmunitypulmonary hypertensionpoultryrequirements
Type
Review Article
Information
World's Poultry Science Journal , Volume 66 , Issue 4 , December 2010 , pp. 751 - 766
Copyright
Copyright © World's Poultry Science Association 2010

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References

ABDUKALYKOVA, S.T., ZHAO, X. and RUIZ-FERIA, C.A. (2008) Arginine and vitamin E modulate the subpopulations of T lymphocytes in broiler chickens. Poultry Science 87: 50-55.CrossRefGoogle ScholarPubMed
ALLEN, P.C. and FETTERER, R.H. (2000) Effect of Eimeria acervulina infections on plasma L-arginine. Poultry Science 79: 1414-1417.CrossRefGoogle ScholarPubMed
ALLEN, P.C. and Lillehoj, H.S. (1998) Genetic influence on nitric oxide production during Eimeria tenella infections in chickens. Avian Disease 42: 397-403.CrossRefGoogle ScholarPubMed
ALMQUIST, H.J., MECCHIANDF, E. and KRATZER, H. (1941) Creatine formation in the chick. Journal of Biological Chemistry 141: 365-373.CrossRefGoogle Scholar
ARNAL, J.F., DINH-XUAN, A.T., PUEYO, M., DARBLADE, B. and RAMI, J. (1999) Endothelium-derived nitric oxide and vascular physiology and pathology. Cellular and Molecular Life Science 55: 1078-1087.CrossRefGoogle ScholarPubMed
AUSTIC, R.E. and NESHEIM, M.C. (1970) Role of kidney arginase in variations of the arginine requirement of chicks. Journal of Nutrition 100: 855-868.CrossRefGoogle ScholarPubMed
AUSTIC, R.E. (1973) Conversion of arginine to proline in the chick. Journal of Nutrition 103: 999-1007.CrossRefGoogle ScholarPubMed
AUSTIC, R.E. and SCOTT, R.L. (1975) Involvement of feed intake in the lysine-arginine antagonism in chicks. Journal of Nutrition 105: 1122-1131.CrossRefGoogle Scholar
AUSTIC, R.E. and CALVERT, C.C. (1981) Nutritional interrelationships of electrolytes and amino acids. Federation Proceedings 40: 63-67.Google Scholar
BAKER, D.H. (2003) Ideal amino acid patterns for broiler chicks, in: D'MELLO, J.P.F. (Ed.) Amino acids in animal nutrition, pp. 223-236 (CABI Publishing).Google Scholar
BALL, R.O., URSCHEL, K.L. and PENCHARZ, P.B. (2007) Nutritional consequences of interspecies differences in arginine and lysine metabolism. Journal of Nutrition 137: 1626S-1641S.CrossRefGoogle ScholarPubMed
BALNAVE, D. and BRAKE, J. (2002) Re-evaluation of the classical dietary arginine:lysine interaction for modern poultry diets: a review. World's Poultry Science Journal 58: 275-289.CrossRefGoogle Scholar
BARBUL, A. (1986) Arginine: biochemistry, physiology, and therapeutic implications. Journal of Parenteral and Enteral Nutrition 10: 227-238.CrossRefGoogle ScholarPubMed
BEDFORD, M.R., SMITH, T.K. and SUMMERS, J.D. (1987) Effect of dietary lysine on polyamine synthesis in the chick. Journal of Nutrition 117: 1852-1858.CrossRefGoogle ScholarPubMed
BEDFORD, M.R., SMITH, T.K. and SUMMERS, J.D. (1988) Regulation of polyamine synthesis by dietary α-aminoisobutyric acid and ornithine. Proceedings of the Society for Experimental Biology and Medicine 188: 509-514.CrossRefGoogle Scholar
BEQUETTE, B. J. (2003) Amino acid metabolism in animals, in: D'MELLO, J.P.F. (Ed.) Amino Acids in Animal Nutrition, pp. 87-101 (CABI Publishing).Google Scholar
BOORMAN, K.N., FALCONER, I.R. and LEWIS, D. (1968) The effect of lysine infusion on the renal reabsorption of arginine in the cockerel. Proceedings of the Nutrition Society 27: 61-62A.Google Scholar
BOWEN, O.T, ERF, G.F., ANTHNONY, N.B. and WIDEMAN, R.F. JR (2006) Pulmonary hypertension triggered by Lipopolysaccharide in ascites-susceptible and –resistant broilers is not amplified by aminoguanidine, a specific inhibitor of inducible nitric oxide synthase. Poultry Science 85: 528-536.CrossRefGoogle Scholar
BOWEN, O.T., ERF, G.F., CHAPMAN, M.E. and WIDEMAN, R.F. (2007) Plasma nitric oxide concentrations in broilers after Intravenous injections of lipopolysaccharide or microparticles. Poultry Science 86: 2550-2554.CrossRefGoogle ScholarPubMed
BRAKE, J., BALNAVE, D. and DIBNER, J.J. (1998) Optimum dietary arginine: lysine ratio for broiler chickens is altered during heat stress in association with changes in intestinal uptake and sodium chloride. British Poultry Science 39: 639-647.CrossRefGoogle ScholarPubMed
BRAKE, J. and BALNAVE, D. (1995) Essentiality of arginine in broilers during hot weather. Proceedings of 12th Annual Biokyowa Amino Acid Council Meeting. Oct. 3-5. St Louis, Mo.Google Scholar
BRONTE, V. and ZANOVELLO, P. (2005) Regulation of immune responses by L-arginine metabolism. Nature Reviews Immunology 5: 641-654.CrossRefGoogle ScholarPubMed
BURTON, E.M. and WALDROUP, P.W. (1979) Arginine and lysine needs of young broiler chicks. Nutrition Report International 19: 607-614.Google Scholar
CHAMRUSPOLLERT, G., PESTI, G.M. and BAKALLI, R.I. (2002) Dietary interrelationships among arginine, methionine, and lysine in young broiler chicks. British Journal of Nutrition 88: 655-660.CrossRefGoogle ScholarPubMed
CHAMRUSPOLLERT, G., PESTI, G.M. and BAKALLI, R.I. (2004) Influence of temperature on the arginine and methionine requirements of young broiler chicks. Journal of Applied Poultry Research 13: 628-638.CrossRefGoogle Scholar
CHAPMAN, M.E. and WIDEMAN, R.F. JR (2006) Evaluation of total plasma nitric oxide concentrations in broilers infused intravenously with sodium nitrite, lipopolysaccharide, aminoguanidine, and sodium nitroprusside. Poultry Science 85: 312-320.CrossRefGoogle ScholarPubMed
CUCA, M. and JENSEN, L.S. (1990) Arginine requirement of starting broiler chicks. Poultry Science 69: 1377-1382.CrossRefGoogle ScholarPubMed
DAVIS, I. and MATALON, S. (2001) Reactive species in viral pneumonitis: Lessons from animal models. News in Physiological Science 16: 185-190.Google ScholarPubMed
DENG, K., WONG, C.W. and NOLAN, J.V. (2005) Long-term effects of early life L-arginine supplementation on growth performance, lymphoid organs and immune responses in Leghorn-type chickens. British Poultry Science 46: 318-324.CrossRefGoogle ScholarPubMed
DIETERT, R.R. and AUSTIC, R.E. (1994) Environment-immune interactions. Poultry Science 73: 1062-1076.CrossRefGoogle ScholarPubMed
DIL, N. and QURESHI, M.A. (2002a) Differential expression of inducible nitric oxide synthase is associated with differential Toll-like receptor-4 expression in chicken macrophages from different genetic backgrounds. Veterinary Immunology and Immunopathology 84: 191-207.CrossRefGoogle ScholarPubMed
DIL, N. and QURESHI, M.A. (2002b) Involvement of LPS-related receptors and nuclear factor kappa-b in differential expression of inducible nitric oxide synthase in chicken macrophages from different genetic backgrounds. Veterinary Immunology and Immunopathology 84: 149-161.CrossRefGoogle Scholar
D'MELLO, J.P.F. and LEWIS, D. (1970) Amino acid interactions in chick nutrition. 3. Interdependence in amino acid requirements. British Poultry Science 11: 367-385.CrossRefGoogle ScholarPubMed
D'MELLO, J.P.F., ACAMOVIC, D. and WALKER, A.G. (1989) Nutritive value of jack beans (Canavalia ensiformis) for young chicks: effects of amino acid supplementation. Tropical Agriculture (Trinidad) 66: 201-205.Google Scholar
D'MELLO, J.P.F. (2003a) Amino acids as multifunctional molecules, in: D'MELLO, J.P.F. Jr. (Ed.) Amino Acids in Animal Nutrition, pp. 87-101 (CABI Publishing).Google Scholar
D'MELLO, J.P.F. (2003b) Adverse effects of amino acids. in: D'MELLO, J.P.F. Jr. (Ed.) Amino Acids in Animal Nutrition, pp. 125-143 (CABI Publishing).Google Scholar
DOMINICZAK, A.F. and BOHR, D.F. (1995) Nitric oxide and its putative role in hypertension. Hypertension 25: 1202-1211.CrossRefGoogle ScholarPubMed
FERNANDEZ, J.I.M., MURAKAMI, A.E., MARTINS, E.N., SAKAMOTO, M.I. and GARCIA, E.R.M. (2009) Effect of arginine on the development of the pectoralis muscle and the diameter and the protein:deoxyribonucleic acid rate of its skeletal myofibers in broilers. Poultry Science 88: 1399-1406.CrossRefGoogle Scholar
FULLER, H.L., CHANG, S.I. and POTTER, D.K. (1967) Detoxication of dietary tannic acid by chicks. Journal of Nutrition 91: 477-483.CrossRefGoogle ScholarPubMed
GHOFRANI, H.A., SEEGER, W. and GRIMMINGER, F. (2008) Phosphodiesterase-5 inhibitors in pulmonary arterial hypertension, in: BARST, R.J. (Ed.) Pulmonary Arterial Hypertension, pp.105-125 (John Wiley & Sons Ltd., NY).Google Scholar
GOKCE, N. (2004) L-arginine and hypertension. Journal of Nutrition 134: 2807S-2811S.CrossRefGoogle ScholarPubMed
HAMAL, K.R., WIDEMAN, R.F. JR, ANTHONY, N. and ERF, G.F. (2008) Expression of inducible nitric oxide synthase in lungs of broiler chickens following intravenous cellulose microparticle injection. Poultry Science 87: 636-644.CrossRefGoogle ScholarPubMed
HAMAL, K.R., WIDEMAN, R.F. JR, ANTHONY, N. and ERF, G.F. (2010) Differential expression of vasoactive mediators in the microparticle-challenged lungs of chickens that differ in susceptibility to pulmonary arterial hypertension. American Journal of Physiology Regulatory Integrative and Comparative Physiology 298: R235-R242.CrossRefGoogle ScholarPubMed
HAMPL, V. and HERGET, J. (2000) Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension. Physiological Reviews 80: 1337-1361.CrossRefGoogle ScholarPubMed
HILL, D.C. and SHAO, T.C. (1968) Effect of arginine on weight gain of chicks consuming diets first-limiting in lysine or tryptophan. Journal of Nutrition 95: 63-66.CrossRefGoogle ScholarPubMed
HUANG, P.L., HUANG, Z., MASHIMO, H., BLOCH, K.D., MOSKOWITZ, M.A. and BEVAN, J.A. (1995) Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377: 239-242.CrossRefGoogle ScholarPubMed
HUSSAIN, I. and QURESHI, M.A. (1997) Nitric oxide synthase and mRNA expression in chicken macrophages. Poultry Science 76: 1524-1530.CrossRefGoogle ScholarPubMed
HUSSAIN, I. and QURESHI, M.A. (1998) The expression and regulation of inducible nitric oxide synthase gene differ in macrophages from chickens of different genetic background. Veterinary Immunology and Immunopathology 61: 317-329.CrossRefGoogle ScholarPubMed
IZADINIA, M., NOBAKHT, M., KHAJALI, F., FARAJI, M., ZAMANI, F.D., QUJEQ, D. and KARIMI, I. (2010) Pulmonary hypertension and ascites as affected by dietary protein source in broiler chickens reared in cool temperature at high altitudes. Animal Feed Science and Technology 155: 194-200.CrossRefGoogle Scholar
JAHANIAN, R. (2009) Immunological responses as affected by dietary protein and arginine concentrations in starting broiler chicks. Poultry Science 88: 1818-1824.CrossRefGoogle ScholarPubMed
JANEWAY, C.A. and MEDZHITOV, R. (2002) Innate immune recognition. Annual Review of Immunology 20: 197-216.CrossRefGoogle ScholarPubMed
KESHAVARZ, K. and FULLER, H.L. (1971a) Relationship of arginine and methionine in the nutrition of the chick and the significance of creatine biosynthesis in their interaction. Journal of Nutrition 101: 217-222.CrossRefGoogle ScholarPubMed
KESHAVARZ, K. and FULLER, H.L. (1971b) Relationship of arginine and methionine to creatine formation in chicks. Journal of Nutrition 101: 855-862.CrossRefGoogle ScholarPubMed
KESSLER, J.W. and THOMAS, O.P. (1976) The arginine requirement of the 4-7 week old broiler. Poultry Science 55: 2379-2382.CrossRefGoogle ScholarPubMed
KHAJALI, F. and IZADINIA, M. (2010) A novel factor that affects the nutritional value of canola meal for broiler strains reared at high altitudes. Proceedings of 13th European Poultry Conference, August 23-27, Tours, France.Google Scholar
KIDD, M.T., PEEBLES, E.D., WHITMARSH, S.K., YEATMAN, J.B. and WIDEMAN, R.F. JR (2001) Growth and immunity of broiler chicks as affected by dietary arginine. Poultry Science 80: 1535-1542.CrossRefGoogle ScholarPubMed
KRAUTMANN, B.A., HAUGE, S.M., MERTZ, E.T. and CARRICK, C.W. (1957) The arginine level for chicks as influenced by ingredients. Poultry Science 36: 935-941.CrossRefGoogle Scholar
KWAK, H., AUSTIC, R.E. and DIETERT, R.R. (1999) Influence of Dietary Arginine Concentration on lymphoid Organ Growth in Chickens. Poultry Science 78: 1536-1541.CrossRefGoogle ScholarPubMed
LABADAN, M.C. JR, HSU, K.N. and AUSTIC, R.E. (2001) Lysine and arginine requirements of broiler chickens at two to three-week intervals to eight weeks of age. Poultry Science 80: 599-606.CrossRefGoogle ScholarPubMed
LEE, J.E., AUSTIC, R.E., NAQI, S.A., GOLEMBOSKI, K.A. and DIETERT, R.R. (2002) Dietary arginine intake alters avian leukocyte population distribution during infectious bronchitis challenge. Poultry Science 81: 793-798.CrossRefGoogle ScholarPubMed
LEWIS, D. (1966) Amino acid interrelationships in poultry nutrition, in: HORTON-SMITH, C. & AMAROSO-OLIVER, E.C. (Eds) Boyd Physiology of the Domestic Fowl, p. 155 (Edinburgh and London).Google Scholar
MARTINEZ-LEMUS, L.A., HESTER, R.K., BECKER, E.J., RAMIREZ, G.A. and ODOM, T.W. (2003) Pulmonary artery vasoactivity in broiler and leghorn chickens: an age profile. Poultry Science 82: 1857-1964.CrossRefGoogle ScholarPubMed
MORENO de SANDINO, M. and HERNANDEZ, A. (2003) Nitric oxide synthase expression in the endothelium of pulmonary arterioles in normal and pulmonary hypertensive chickens subjected to chronic hypobaric hypoxia. Avian Diseases 47: 1291-1297.CrossRefGoogle ScholarPubMed
MORENO de SANDINO, M. and HERNANDEZ, A. (2006) Pulmonary arteriole remodeling in hypoxic broilers expressing different amounts of endothelial nitric oxide synthase. Poultry Science 85: 899-901.CrossRefGoogle ScholarPubMed
MORRIS, S.M. JR (2007) Arginine metabolism: Boundaries of our knowledge. Journal of Nutrition 137: 1602S-1609S.CrossRefGoogle ScholarPubMed
MURAKAMI, K. and TRABER, D.L. (2003) Pathophysiology basis of smoke inhalation injury. News in Physiological Sciences 18: 125-129.Google ScholarPubMed
MURAMATSU, T. and OKUMURA, J. (1980) Influence of dietary energy on the nitrogen sparing action of methionine and arginine in chicks fed a protein-free diet. Journal of Nutrition 110: 59-65.CrossRefGoogle ScholarPubMed
NESHEIM, M.C. (1968) Kidney arginase activity and lysine tolerance in strains of chickens selected for a high or low requirement of arginine. Journal of Nutrition 95: 79-87.CrossRefGoogle ScholarPubMed
NATIONAL RESEARCH COUNCIL, (1994) Nutrient Requirements of Poultry, 9th ed. National Academy Press, Washington DC.Google Scholar
ODELL, B.L. and SAVAGE, J.E. (1966) Arginine-lysine antagonism in the chick and its relationship to dietary cations. Journal of Nutrition 90: 364-370.CrossRefGoogle ScholarPubMed
ODOM, T.W., MARTINEZ-LEMUS, L.A., HESTER, R.K., BECKER, E.J., JEFFREY, J.S., MEININGER, G.A. and RAMIREZ, G.A. (2004) In vitro hypoxia differentially affects constriction and relaxation responses of isolated pulmonary arteries from broiler and leghorn chickens. Poultry Science 83: 835-841.CrossRefGoogle ScholarPubMed
POPOVIC, P.J., ZEH, H.Z. and OCHOA, J.B. (2007) Arginine and immunity. Journal of Nutrition 137: 1681S-1686S.CrossRefGoogle ScholarPubMed
QURESHI, M.A. (2003) Avian Macrophage and Immune Response: An Overview. Poultry Science 82: 691-698.CrossRefGoogle ScholarPubMed
RICCIARDOLO, F.L.M., STERK, P.J., GASTON, B. and GERTFOLKERTS, B. (2004) Nitric oxide in health and disease of the respiratory system. Physiological Review 84: 731-765.CrossRefGoogle ScholarPubMed
RUEDA, E., MICHELANGELI, C. and GONZALEZ-MUJICA, F. (2003) L-Canavanine inhibits L-arginine uptake by broiler chicken intestinal brush border membrane vesicles. British Poultry Science 44: 620-625.CrossRefGoogle Scholar
RUIZ-FERIA, C.A., KIDD, M.T. and WIDEMAN, R.F. JR (2001) Plasma levels of arginine, ornithine, and urea, and growth performance of broilers fed supplemental L-arginine during cool temperature exposure. Poultry Science 80: 358-369.CrossRefGoogle ScholarPubMed
RUIZ-FERIA, C.A. (2009) Concurrent supplementation of arginine, vitamin E, and vitamin C improve cardiopulmonary performance in broilers chickens. Poultry Science 88: 526-535.CrossRefGoogle ScholarPubMed
RUIZ-FERIA C.A., and ABDUKALYKOVA, S.T. (2009) Arginine and Vitamin E improve the antibody responses to infectious bursal disease virus (IBDV) and sheep red blood cells in broiler chickens. British Poultry Science 50: 291-29CrossRefGoogle ScholarPubMed
SMITH, T.K. (1990) Effect of dietary putrescine on whole body growth and polyamine metabolism. Proceedings of the Society for Experimental Biology and Medicine 194: 332-336.CrossRefGoogle ScholarPubMed
SNETSINGER, D.C. and SCOTT, H.M. (1961) Efficacy of glycine and arginine in alleviating the stress induced by dietary excesses of single amino acids. Poultry Science 40: 1675-1681.CrossRefGoogle Scholar
SRINONGKOTE, S., SMRIGA, M. and TORIDE, Y. (2004) Diet supplied with L-lysine and L-arginine during chronic stress of high stock density normalizes growth of broilers. Animal Science Journal 75: 339-343.CrossRefGoogle Scholar
SU, C.L. and AUSTIC, R.E. (1999) The recycling of L-citrulline to L-arginine in a chicken macrophage cell line. Poultry Science 78: 353-355.CrossRefGoogle Scholar
SUCHNER, U., HEYLAND, D.K. and PETER, K. (2002) Immune-modulatory actions of arginine in the critically ill. British Journal of Nutrition 87: S121-S132.CrossRefGoogle ScholarPubMed
SUNG, Y.J., HOTCHKISS, J.H., AUSTIC, R.E. and DIETERT, R.R. (1991) L-Arginine-dependent production of a reactive nitrogen intermediate by macrophages of a uricotelic species. Journal of Leukocyte Biology 50: 49-56.CrossRefGoogle ScholarPubMed
TAMIR, H. and RATNER, S. (1963a) Enzymes of arginine metabolism in chicks. Archive for Biochemistry and Biophysics 102: 249-258.CrossRefGoogle ScholarPubMed
TAMIR, H. and RATNER, S. (1963b) A study of ornithine, citrulline, and arginase synthesis in growing chicks. Archive for Biochemistry and Biophysics 102: 259-269.CrossRefGoogle Scholar
TAN, X., PAN, J.Q., LI, J.C., LIU, Y.J., SUN, W.D. and WANG, X.L. (2005) L-arginine inhibiting pulmonary vascular remodelling is associated with promotion of apoptosis in pulmonary arterioles smooth muscle cells in broilers. Research in Veterinary Science 79: 203-209.CrossRefGoogle ScholarPubMed
TAN, X., SUN, W.D., HU, X.Y., LI, J.C., PAN, J.Q., WANG, J.Y. and WANG, X.L. (2006) Changes in pulmonary arteriole protein kinase Cα expression associated with supplemental L-arginine in broilers during cool temperature exposure. British Poultry Science 47: 230-236.CrossRefGoogle ScholarPubMed
TAN, X., HU, S. and WANG, X.L. (2007) Possible role of nitric oxide in the pathogenesis of pulmonary hypertension in broilers: a synopsis. Avian Pathology 36: 261-267.CrossRefGoogle ScholarPubMed
TAYLOR, R.L., AUSTIC, R.E. and DIETERT, R.R. (1992) Dietary arginine influences Rous sarcoma growth in a major histocompatibility B complex progressor genotype. Proceedings of Society of Experimental Biology and Medicine 199: 38-41.CrossRefGoogle Scholar
TESHFAM, M., BRUJENI, G.M. and HASSANPOUR, H. (2006) Evaluation of endothelial and inducible nitric oxide synthase mRNA expression in the lung of broiler chickens with developmental pulmonary hypertension due to cold stress. British Poultry Science 47: 223-229.CrossRefGoogle ScholarPubMed
TOMAS-COBOS, T., MINAMBRES, R., RODRIGO, A., NAVARRO, A. and TOMAS, D. (2008) Arginine and the immune system. Proceedings of Nutrition Society 67(OCE) E3.CrossRefGoogle Scholar
VILLAMOR, E., RUIJTENBEEK, K., PULGAR, V., DE MEY, J.G.R. and BLANCO, C.E. (2002) Vascular reactivity in intrapulmonary arteries of chicken embryos during transition to ex ovo life. American Journal of Physiology 282: R917-R927.Google ScholarPubMed
WANG, J., WANG, X., XIANG, R. and SUN, W. (2002) Effect of L-NAME on pulmonary arterial pressure, plasma nitric oxide and pulmonary hypertension syndrome morbidity in broilers. British Poultry Science 43: 615-620.CrossRefGoogle ScholarPubMed
WEIDONG, S., XIAOLONG, W., JINYONG, W. and RUIPING, J. (2002) Pulmonary arterial pressure and electrocardiograms in broiler chickens infused intravenously with L-NAME, an inhibitor of nitric oxide synthase, or sodium nitroprusside (SNP), a nitric oxide donor. British Poultry Science 43: 306-312.CrossRefGoogle ScholarPubMed
WIDEMAN, R.F. and BOTTJE, W.G. (1993) Current understanding of the ascites syndrome and future research directions. Pages 1-20 In: Nutrition and Technical Symposium Proceedings. Novus International, Inc., St. Louis, MO.Google Scholar
WIDEMAN, R.F. JR, KIRBY, Y.K., ISMAIL, M., BOTTJE, W.G., MOORE, R.W. and VARDEMAN, R.C. (1995) Supplemental L-arginine attenuates pulmonary hypertension syndrome (ascites) in broilers. Poultry Science 74: 323-330.CrossRefGoogle ScholarPubMed
WIDEMAN, R.F. JR, KIRBY, Y.K., FORMAN, M., TACKET, C.D., MARSON, N.E. and MCNEW, R.W. (1996) Cardiopulmonary function during acute unilateral occlusion of pulmonary artery in broilers fed diets containing normal or high levels of arginine-HCl. Poultry Science 75: 1587-1602.CrossRefGoogle ScholarPubMed
WIDEMAN, R.F. JR, ERF, G.F. and CHAPMAN, M.E. (2001) Intravenous endotoxin triggers pulmonary vasoconstriction and pulmonary hypertension in broiler chickens. Poultry Science 80: 647-655.CrossRefGoogle ScholarPubMed
WIDEMAN, R.F. JR and CHAPMAN, M.E. (2004) Nω-nitro-L-arginine methyl ester (L-NAME) amplifies the pulmonary hypertensive response to endotoxin in broilers. Poultry Science 83: 485-494.CrossRefGoogle Scholar
WIDEMAN, R.F. JR, CHAPMAN, M.E., WANG, W. and EER, G.F. (2004) Immune modulation of the pulmonary hypertensive response to bacterial lipopolysaccharide (endotoxin) in broilers. Poultry Science 83: 624-637.CrossRefGoogle ScholarPubMed
WIDEMAN, R.F. JR, ERF, G.F. and CHAPMAN, M.E. (2005) Nω-nitro-L-arginine methyl ester (L-NAME) amplifies the pulmonary hypertensive response to microparticle injections in broilers. Poultry Science 84: 1077-1091.CrossRefGoogle ScholarPubMed
WIDEMAN, R.F. JR, BOWEN, O.T., ERF, G.F. and CHAPMAN, M.E. (2006) Influence of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on the pulmonary hypertensive response to micro-particle injections in broilers. Poultry Science 85: 511-527.CrossRefGoogle Scholar
WIDEMAN, R.F. JR, CHAPMAN, M.F., HAMAL, K., BOWEN, O.T., LORENZONI, A.G., ERF, G.F. and ANTHONY, N.B. (2007) An inadequate pulmonary vascular capacity and susceptibility to pulmonary arterial hypertension in broilers. Poultry Science 86: 984-998.CrossRefGoogle ScholarPubMed
WU, G., FLYNN, N.E., FLYNN, S.P., JOLLY, C.A. and DAVIS, P.K. (1999) Dietary protein or arginine deficiency impairs constitutive and inducible nitric oxide synthesis by young rats. Journal of Nutrition 129: 1347-1354.CrossRefGoogle ScholarPubMed