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Bioactive egg components and their potential uses

Published online by Cambridge University Press:  01 September 2006

M. ANTON ,
F. NAU  and
Y. NYS
M. ANTON*
Affiliation:
INRA BIA, ISD Group, BP 71627, 44316 Nantes cedex 3, France;
F. NAU
Affiliation:
UMR 1253 INRA-Agrocampus Rennes, 65 rue de Saint-Brieuc, CS84215, 35042Rennes cedex, France;
Y. NYS
Affiliation:
INRA Station de Recherches Avicoles, 37380Nouzilly, France
*
*Corresponding author: [email protected]
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Abstract

The hen's egg plays a crucial role in the embryonic development of the bird. It serves first as a source of energy and nutrients of high digestibility and, second, protects the embryonic bird against external aggressions. The unique structure of an egg with yolk containing the embryo surrounded by albumen and shell as physical barriers, is the first element of this protection. The second one consists of the specific composition of yolk, albumen and shell with many molecules possessing elevated biological properties. Thus, these molecules represent a major source of active principles usable by medical, pharmaceutical, cosmetic, nutraceutical and biotechnological industries. In this review, we will focus particularly on nutritional, health, and biotechnological activities of egg molecules and on the approaches, which are proposed by European research groups, to exploit this bioactive potential.

Keywords

eggmoleculesbiological properties
Type
Review Article
Information
World's Poultry Science Journal , Volume 62 , Issue 3 , September 2006 , pp. 429 - 438
Copyright
Copyright © World's Poultry Science Association 2006

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Footnotes

From a paper first presented at the XIth European Symposium on the Quality of Eggs and Egg Products, Doorwerth, The Netherlands, 23–26 May 2005

References

ANTON, M. and GANDEMER, G. (1997) Composition, solubility and emulsifying properties of granules and plasma of hen egg yolk. Journal of Food Science 62 (3): 484–487.CrossRefGoogle Scholar
ARAKI, S., SUZUKI, M. and FUJIMOTO, M. (1992) Enhanced resistance to bacterial infections in mice by oral administration of an active egg white product. Journal of Veterinary Medical Science 54 (5): 1055–1056.CrossRefGoogle ScholarPubMed
ARO, H. (2003) Simultaneous pilot-scale extraction and precipitation of egg yolk phospholipids using supercritical techniques. Xth European Symposium on the Quality of Eggs and Egg Products, Ploufragan, 23–26th sept.Google Scholar
BABINI, G.S. and LIVERMORE, D.M. (2000) Effect of conalbumin on the activity of Syn2190, a 1,5 dihydroxy-4-pyridon monobactam inhibitor of AmpC β-lactamases. Journal of Antimicrobial Chemotherapy 45: 105–109.CrossRefGoogle ScholarPubMed
BARON, F. (1998) Etude du comportement de Salmonella enteritidis dans le blanc d'œuf. PhD thesis, ENSA Rennes, France, 120 p.Google Scholar
BAYER, E.A. and WILCHEK, M. (1994) Modified avidins for application in avidin-biotin technology: an improvement on nature. In: Egg uses and processing technologies, new developments, Sim, Nakai Eds, CAB Int., Oxon, UK,pp158–176.Google Scholar
CANSELL, M., NACKA, F. and COMBE, N. (2003) Marine lipid-based liposomes increase in vivo fatty acid bioavailability. Lipids 38: 551–559.CrossRefGoogle Scholar
CASTELLANI, O., GUÉRIN-DUBIARD, C., DAVID-BRIAND, E. and ANTON, M. (2004) Influence of physico-chemical conditions and technological treatment on the iron binding capacity of hen egg phosvitin. Food Chemistry 85: 569–577.CrossRefGoogle Scholar
COOK, W.H. and MARTIN, W.G. (1969) Egg lipoproteins. In: Tria, E, Scanu, AM (eds) Structural and Functional Aspects of Lipoproteins in Living Systems. New York: Academic Press, pp 579–615.Google Scholar
CROGUENNEC, T., NAU, F., PÉZENNEC, S., PIOT, M. and BRULÉ, G. (2001) Two-step chromatographic procedure for the preparation of hen egg white ovotransferrin. European Food Research and Technology 212: 296–301.CrossRefGoogle Scholar
DE DOUDER, C. and MORIAS, J. (1974) On lysozyme therapy. II. Topical treatment of viral and non viral cutaneous lesions with lysozyme ointment. Medickon 3: 21–22.Google Scholar
DE GRAAF, L.A. and KOLSTER, P. (1998) Industrial proteins as a green alternative for ‘PETRO’ polymers: potentials and limitations. Macromolecular Symposia 127: 51–58.CrossRefGoogle Scholar
DEL GIACCO, G.S., LEONE, A.L. and FERLAZZO, A. (1985) Total IgE in newborns treated prophylactically with conalbumin. International Journal of Tissue Reactivity 7: 535–537.Google ScholarPubMed
FOULKES, J.A. (1977) The separation of lipoproteins from egg yolk and their effect on the motility and integrity of bovine spermatozoa. Journal of Reproduction and Fertility 49: 277–284.CrossRefGoogle ScholarPubMed
FUJITA, H., SASAKI, R. and YOSHIKAWA, M. (1995) Potentiation of the antihypertensive activity of orally administered ovokinin, a vasorelaxing peptide derived from ovalbumin, by emulsification in egg phosphatidyl-choline. Bioscience, Biotechnology and Biochemistry 59 (12): 2344–2345.CrossRefGoogle Scholar
GASPARRI, A., MORO, M., CURNIS, F., SACCHI, A., PAGANO, S., VEGLIA, F., CASORATI, G., SICCARDI, A.G., DELLABONA, P. and CORTI, A. (1999) Tumour pretargeting with avidin improves the therapeutic index of biotinylated tumour necrosis factor a in mouse models. Cancer Research 59: 2917–2923.Google ScholarPubMed
GAVRILENKO, T.I., SIURIN, S.A., LOLAEVA, L.T. and SAUCHENKO, V.M. (1992) The characteristics of lysozyme and carbenicillin action on the clinico-immunological status of patients with chronic bronchitis. Vrachebnoe Delo 8: 42–45.Google Scholar
GRAHAM, J.K. and FOOTE, R.H. (1987) Effect of several lipids. fatty acyl chain length and degree of unsaturation on the motility of bull spermatozoa after cold shock and freezing. Cryobiology 24: 42–52.CrossRefGoogle ScholarPubMed
GUTIERREZ, M.A., TAKAHASHI, H. and JUNEJA, L.R. (1997) Nutritive evaluation of hen eggs, In: Yamamoto, T., Juneja, L., Hatta, H., Kim, M. (Eds.), CRC Press, Boca Raton (USA) pp. 25–35.Google Scholar
IBRAHIM, H.R., SUGIMOTO, Y. and AOKI, T. (2000) Ovotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism. Biochimica Biophysica Acta 1523: 196–205.CrossRefGoogle ScholarPubMed
ITOH, T., ABE, Y. and ADACHI, S. (1983) Comparative studies on the α- and β-phosvitin from hen's egg yolk. Journal of Food Science 48: 1755–1757.CrossRefGoogle Scholar
JEREZ, A., PARTAL, P., MARTINEZ, I., GALLEGOS, C. and GUERRERO, A. (2005) Rheology and processing of gluten based bioplastics. Biochemical Engineering Journal 26: 131–138.CrossRefGoogle Scholar
JOHNSON, E.A. (1994) Egg white lysozyme as a preservative for use in foods. In: Egg uses and processing technologies, new developments, Sim, Nakai Eds, CAB Int., Oxon, UK, pp 177–191.Google Scholar
JUNEJA, L.R. (1997) Egg yolk yolk lipids, In: Yamamoto, T., Juneja, L., Hatta, H., Kim, M. (Eds.), CRC Press, Boca Raton (USA) pp. 73–98.Google Scholar
KATO, T., IMATANI, T., MIURA, T., MINAGUCHI, K., SAITOH, E. and OKUDA, K. (2000) Cytokineinducing activity of family 2 cystatins. Biological Chemistry 381: 1143–1147.CrossRefGoogle ScholarPubMed
KIJOWSKI, J. and LESNIEROWSKI, G. (1999) Separation, polymer formation and antibacterial activity of lysozym. Polish Journal of Food and Nutrition Sciences 49: 3–16.Google Scholar
LESKANISH, C.O. and NOBLE, R.C. (1997) Manipulation of the n-3 polyunsaturated fatty acid composition of avian egg and meat. World's Poultry Science Journal 53: 253–264.Google Scholar
LESLIE, G.A. and CLEM, L.W. (1969) Phylogeny of immunoglobulin structure and function. III. Immunoglobulin of the chicken. Journal of Experimental Medicine 130: 1337–1945.CrossRefGoogle Scholar
LOCK, J.L. and BOARD, R.G. (1992) Persistence of contamination of hen's egg albumen in vitro with Salmonella serotypes. Epidemiology and Infection 108: 389–396.CrossRefGoogle Scholar
LU, C.L. and BAKER, R.C. (1986) Characteristics of egg yolk phosvitin as an antioxidant for inhibiting metalcatalyzed phospholipid oxidation. Poultry Science 65: 2065–2073.CrossRefGoogle Scholar
MAKI, K.C., VAN ELSWYK, M.E., MCCARTHY, D., SEELEY, M.A., VEITH, P.E., HESS, S.P., INGRAM, K.A., HALVORSON, J.J., CALAGUAS, E.M. and DAVIDSON, M.H. (2003) Lipid responses in mildly hypertriglyceridemic men and women to consumption of docosahexaenoic acid-enriched eggs. International Journal for Vitamin and Nutrition Research 73: 357–368.CrossRefGoogle ScholarPubMed
MATTILA, P., LEHIKOINEN, K., KIISKINEN, T. and PIIRONEN, V. (1999) Cholecalciferol and 25-hydroxycholecalciferol content of chicken egg yolk as affected by the cholecalciferol content of feed. Journal of Agricultural and Food Chemistry 47: 4089–4092.CrossRefGoogle ScholarPubMed
MATOBA, N., USUI, H., FUJITA, H. and YOSHIKAWA, M. (1999) A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Letters 452: 181–184.CrossRefGoogle Scholar
MATOBA, N., YAMADA, Y., USUI, H., NAKAGIRI, R. and YOSHIKAWA, M. (2001) Designing potent derivatives of ovokinin(2–7), an anti-hypertensive peptide derived from ovalbumin. Bioscience, Biotechnology and Biochemistry 65 (3): 736–739.CrossRefGoogle ScholarPubMed
MIGUEL, M., RECIO, J.A., GOMEZ-RUIZ, A., RAMOS, M. and LOPEZ-FANDINO, R. (2004) Angiotensin I-converting enzyme inhibitory activity of peptides derived from egg white proteins by enzymatic hydrolysis. Journal of Food Protection 67: 1914–1920.CrossRefGoogle ScholarPubMed
MOUSSA, M., MARTINET, V., TRIMECHE, A., TAINTURIER, D. and ANTON, M. (2002) Low density lipoproteins extracted from hen egg yolk by an easy method: Cryoprotective effect on freeze-thaw bull semen. Theriogenology 57: 1695–1706.CrossRefGoogle Scholar
NAKAGAWA, J., OSAME, S., ICHIJO, S., ARAKI, S. and KIMURA, M. (1993) Effects of active egg white product on neutrophil function in calves. Journal of Veterinary Medical Science 55 (2): 259–263.CrossRefGoogle ScholarPubMed
NAKAI, S. (2000) Molecular modification of egg proteins for functional improvement. In: Egg nutrition and biotechnology, Sim, Nakai and Guenter, Eds,CAB Int., Oxon, UK, pp 205–217.Google Scholar
NAKAI, S., LI-CHAN, E. and LO, K.V. (1994) Separation of yolk immunoglobulin, In: Egg Uses & Processing Technologies. New Developments. Sim, J.S., Nakai, S. (Eds.), CAB International, Oxon (UK), pp. 94–105.Google Scholar
NAU, F., GUÉRIN-DUBIARD, C., DÉSERT, C., GAUTRON, J., BOUTON, S., GRIBONVAL, J. and LAGARRIGUE, S. (2003) Cloning and characterization of HEP21, a new member of the uPAR/Ly6 protein superfamily predominantly expressed in hen egg white. Poultry Science 82: 242–250.CrossRefGoogle ScholarPubMed
NAU, F., PASCO, M., DÉSERT, C., MOLLÉ, D., CROGUENNEC, T. and GUÉRIN-DUBIARD, C. (2005) Identification and characterization of ovalbumin gene Y in hen egg white. Journal of Agricultural and Food Chemistry 53: 2158–2163.CrossRefGoogle ScholarPubMed
NYS, Y., GAUTRON, J., GARCIA-RUIZ, J.M. and HINCKE, M.T. (2004) Avian eggshell mineralization: biochemical and functional characterization of matrix proteins. Comptes Rendus Palevo 3: 549–562.CrossRefGoogle Scholar
ROSE, M.E., ORLANS, E. and BUTTRESS, N. (1974) Immunoglobulin classes in the hen's egg: their segregation in yolk and white. European Journal of Immunology 4: 521–523.CrossRefGoogle ScholarPubMed
SAVA, G. (1996) Pharmacological aspects and therapeutic applications of lysozymes. Exs 75: 433–449.Google ScholarPubMed
SCHADE, R., STAAK, C., HENDRIKSEN, C., ERHARD, M., HUGL, H., KOCH, G., LARSSON, A., POLLMANN, W., VAN REGENMORTEL, M., RIJKE, E., SPIELMANN, H., STEINBUSCH, H. and STRAUGHAN, D. (1996) The production of avian (egg yolk) antibodies: IgY. ECVAM Workshop 21. ATLA 24, 925–934.Google Scholar
SCHADE, R. and SCHWÄGELE, F. (2004) Production of neutralizing IgY antibody against toxins and hazardous viruses. COST 923 workshop, 38.Google Scholar
SHIN, N., KIM, J., CHOI, I. and YOO, H. (2001) Control of swine respiratory disease using egg yolk antibodies. Korean Journal of Veterinary Research 41: 197–202.Google Scholar
TENOVUO, J., LUMIKARI, M. and SOUKKA, T. (1991) Salivary lysozyme, lactoferrin and peroxidases: antibacterial effects on cariogenic bacteria and clinical applications in preventive dentistry. Proceedings of the Finnish Dental Society 87: 197–208.Google ScholarPubMed
TINI, M., JEWELL, U.R., CAMANISH, G., CHILOV, D. and GASSMANN, M. (2002) Generation and application of chicken egg-yolk antibodies. Comparative Biochemistry and Physiology A 131: 569–574.CrossRefGoogle ScholarPubMed
TSUGE, Y., SHIMOYAMADA, M. and WATANABE, K. (1996) Differences in hemagglutination inhibition activity against bovine rotavirus and hen Newcastle disease virus based on the subunits in hen egg white ovomucin. Bioscience, Biotechnology and Biochemistry 60 (9): 1505–1506.CrossRefGoogle ScholarPubMed
VALENTI, P., ANTONINI, G., VON HUNOLSTEIN, C., VISCA, P., ORSI, N. and ANTONINI, E. (1983) Studies on the antimicrobial activity of ovotransferrin. International Journal of Tissue Reactivity 5 (1): 97–105.Google ScholarPubMed
VALENTI, P., VISCA, P., ANTONINI, G. and ORSI, N. (1986) Interaction between lactoferrin and ovotransferrin and Candida cells. FEMS Microbiological Letters 33: 271–275.CrossRefGoogle Scholar
VERDOT, L., LALMANACH, G., VERCRUYSSE, V., HARTMANN, S., LUCIUS, R., HOEBEKE, J., GAUTHIER, F. and VRAY, B. (1996) Cystatins upregulated nitric oxide release from interferon-g-activated mouse peritoneal macrophages. Journal of Biological Chemistry 271: 28077–28081.CrossRefGoogle ScholarPubMed
VERMEIRSSEN, V., VAN DER BENT, A., VAN CAMP, J., VAN AMERONGEN, A. and VERSTRAETE, W. (2004) A quantitative in silico analysis calculates the angiotensin I converting enzyme (ACE) inhibitory activity in pea and whey protein digests. Biochimie 86: 231–239.CrossRefGoogle ScholarPubMed
VINGERHOEDS, M. (2004) Proteins: natural and flexible materials for microencapsulation. Polymers: Delivering new Performances to Microcapsules, Liège, Belgium – November 9–10.Google Scholar
VOHRINGER, C. and SANDER, E. (2001) Comparison of antibodies in chicken egg yolk (IgY) and rabbit (IgG) for quantitative strain detection of Colletotrichum falcatum and Fusarium subglutinans with Elisa. Zeitschrift für Pflanzenkrankheiten und Plflanzenschhutz 108: 39–48.Google Scholar
YANNAKOPOULOS, A., TSERVENI-GOUSI, A., DIMOVELIS, P., FORTOMARIS, P. and SOSSIDOU, E. (2003) Poultry production in mountain regions in Greece. International Symposium” Animal Production and Natural Resources Utilisation in the Mediterranean Mountain Areas. June 5–7. Ioannina, Greece.Google Scholar