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An update on potential applications of L-carnitine in poultry

Published online by Cambridge University Press:  17 October 2017

Z. REHMAN ,
S. NAZ ,
R.U. KHAN  and
M. TAHIR
Z. REHMAN
Affiliation:
Faculty of Animal Husbandry & Veterinary Sciences, the University of Agriculture, Peshawar, Pakistan
S. NAZ*
Affiliation:
Department of Zoology, GC University, Faisalabad, Pakistan
R.U. KHAN
Affiliation:
Faculty of Animal Husbandry & Veterinary Sciences, the University of Agriculture, Peshawar, Pakistan
M. TAHIR
Affiliation:
Faculty of Animal Husbandry & Veterinary Sciences, the University of Agriculture, Peshawar, Pakistan
*
Corresponding author: [email protected]
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Abstract

L-carnitine (B-hydroxy-Y-N-trimethyl aminobutyrate) is a water-soluble product, found in animals, plants and microorganisms. Its synthesis takes place from two important amino acids, lysine and methionine. Essentially, L-carnitine has an intermediary role in metabolism. It promotes energy metabolism for cell and regulates co-enzyme A concentration in cystosol and mitochondria, which are important in glucose and lipid metabolism. L-carnitine was first isolated from the chicken embryo in a significant amount, but is absent in the egg. Under normal physiological conditions, the endogenously synthesised levels are sufficient for normal growth and functions. Its requirements are increased in stressful conditions and during metabolic and physiological higher demands, such as growth and laying periods. L-carnitine increases energy production, fat metabolism and improves immune status in birds, which is energy demanding. In this review, several aspects of the beneficial effects of dietary supplementation of L-carnitine on poultry health and production are briefly summarised.

Keywords

L-carnitinephysiologypoultry
Type
Reviews
Information
World's Poultry Science Journal , Volume 73 , Issue 4 , December 2017 , pp. 823 - 830
Copyright
Copyright © World's Poultry Science Association 2017 

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References

ADABI, SH.G., COOPER, R.G., CEYLAN, N. and CORDUK, M. (2011) L-carnitine and its functional effects in poultry nutrition. World's Poultry Science Journal 67: 277-296.Google Scholar
ASADI, H., SADEGHI, A.A., EILA, N. and AMINAFSHAR, M. (2016) Carcass traits and immune response of broiler chickens fed dietary L-carnitine, coenzyme Q10 and Ractopamine. Brazilian Journal of Poultry Science 18: 677-682.Google Scholar
ARSLAN, C. (2006) L-Carnitine and its use as a feed additive in poultry feeding a review. Revue de Médecine Vétérinaire 157: 134-142.Google Scholar
ARSLAN, C., CITIL, M. and SAATCI, M. (2003) Effects of L-carnitine administration on growth performance, carcass traits, blood serum parameters and abdominal fatty acid composition of ducks. Archives of Animal Nutrition 57: 381-388.CrossRefGoogle Scholar
ARSLAN, C., CITIL, M. and SAATCI, M. (2004a) Effects of L-carnitine administration on growth performance, carcass traits, serum lipids and abdominal fatty acid compositions of geese. Revue de Médecine Vétérinaire 155: 315-320.Google Scholar
ARSLAN, C., CITIL, M. and SAATCI, M. (2004b) Effects of L-carnitine administration on growth performance, carcass traits and some serum components of Japanese quail (Coturnix cot. japonica). Archiv für Geflügelkunde 68: 111-114.Google Scholar
BARKER, D.L. and SELL, J.L. (1994) Dietary carnitine did not influence performance and carcass composition of broiler chickens and young turkeys fed low- or high-fat diets. Poultry Science 73: 281-287.CrossRefGoogle ScholarPubMed
BECCAVIN, C., CHEVALIER, B., COGBURN, L.A., SIMON, J. and DUCLOS, M.J. (2001) Insulin-like growth factors and body growth in chickens divergently selected for high or low growth rate. Journal of Endocrinology 168: 297-306.CrossRefGoogle ScholarPubMed
BREMER, J. (1983) Carnitine-metabolism, functions. Physiological Reviews 63: 1420-1480.CrossRefGoogle ScholarPubMed
BUYSE, J., JANSSENS, G.P.J. and DECUYPERE, E. (2001) The effects of dietary L-carnitine supplementation on the performance, organ weights and circulating hormone and metabolite concentrations of broiler chickens reared under abnormal or low temperature schedule. British Poultry Science 42: 230-241.CrossRefGoogle ScholarPubMed
CELIK, L. and OZTURKCAN, O. (2003) Effects of dietary supplemental L-carnitine and ascorbic acid on performance, carcass composition and plasma L-carnitine concentration of broiler chicks reared under different temperature. Archives of Animal Nutrition 57: 27-38.Google Scholar
CELIK, L.B., TEKELI, A. and ÖZTÜRKCAN, O. (2004) Effects of supplemental L-carnitine in drinking water on performance and egg quality of laying hens exposed to a high ambient temperature. Journal of Animal Physiology and Animal Nutrition 88: 229-233.Google Scholar
CORDUK, M., CEYLAN, N. and ILDIZ, F. (2007) Effects of dietary energy density and L-carnitine supplementation on growth performance, carcass traits and blood parameters of broiler chickens. South African Journal of Animal Science 37: 65-73.Google Scholar
HRNČÁR, C., VERGULIAKOVÁ, S., SVORAD, P., WEIS, J., APRÁŠOVÁ, H., MINDEK, S., FIK, M. and BUJKO, J. (2015) Effect of L-carnitine supplementation on fattening and carcass parameters of broiler chickens. Acta Fytotechnica et Zootechnica 18: 15-19.Google Scholar
DASKIRAN, M., ONOL, A.G., CENGIZ, O., TATLI, O. and SARI, M. (2009) Effects of dietary methionine levels and L-carnitine supplementation on performance and egg quality parameters of layers. Journal of Animal and Feed Science 18: 650-661.CrossRefGoogle Scholar
DERIN, N., IZGUT, U.V.N., ALICIGUZEL, A.A.G.A.C.Y. and DEMIR, N. (2004) L-Carnitine protects gastric mucosa by decreasing ischemia-reperfusion induced lipid per oxidation. Journal of Physiology and Pharmacology 55: 595-606.Google Scholar
DENG, K., WONG, C.W. and NOLAN, J.V. (2006) Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens. Journal of Animal Physiology and Animal Nutrition 90: 81-86.Google Scholar
FAMULARO, G., DE SIMONE, C., TRINCHIERI, V. and MOSCA, L. (2004) Carnitine and its congeners: a metabolic pathway to the regulation of immune response and inflammation. Annals of New York Academy of Science 1033: 132-138.CrossRefGoogle Scholar
GENG, A., LI, B. and GUO, Y. (2007) Effects of dietary L-carnitine and coenzyme Q10 at different supplemental ages on growth performance and some immune response in ascites-susceptible broilers. Archives of Animal Nutrition 61: 50-60.Google Scholar
GENG, A., GUO, Y. and YUAN, J. (2004) Effects of dietary L-carnitine and coenzyme Q10 supplementation on performance and ascites mortality of broilers. Archive of Animal Nutrition 58: 473-482.CrossRefGoogle ScholarPubMed
GHODS-ALAVI, B., SAMIE, H. and JAHANIAN, R. (2010) Effects of supplementary dietary L-carnitine on performance and egg quality of laying hens fed diets different in fat level. Italian Journal of Animal Science 9: e3.Google Scholar
HASSAN, M.S.H., YOUSSEF, S.F. and EL-BAHY, N.M.A. (2011) Effects of l-carnitine and ascorbic acid supplementation on productive, reproductive, physiological and immunological performance of golden montazah laying hens. Egyptian Poultry Science 31: 557-578.Google Scholar
HOSSEINTABAR, B., DADASHBEIKI, M., BOUYEH, M., SEIDAVI, A., VAN DEN HOVEN, R. and GAMBOA, S. (2015) Effect of different levels of L-carnitine and lysine-methionine on broiler blood parameters. Revista MVZ Cordoba 20: 4698-4708.Google Scholar
KAZEMI-FARD, M., YOUSEFI, S., DIRANDEH, E. and REZAEI, M. (2015) Effect of different levels of L-carnitine on the productive performance, egg quality, blood parameters and egg yolk cholesterol in laying hens. Poultry Science Journal 3: 105-111.Google Scholar
KARADENIZ, A., SIMSEK, N. and CAKIR, S. (2008) Haematological effects of dietary L- carnitine supplementation in broiler chickens. Revue de Médecine Vétérinaire 159: 437-443.Google Scholar
KHAN, R.U. (2011) Antioxidants and poultry semen quality. World's Poultry Science Journal 67: 297-308.Google Scholar
KHAN, R.U., NAZ, S., NIKOUSEFAT, Z., TUFARELLI, V., JAVADANI, M., RANA, N. and LAUDADIO, V. (2011) Effect of vitamin E in heat-stressed poultry. World's Poultry Science Journal 67 (3): 469-478.Google Scholar
KHAN, R.U., RAHMAN, Z.U., JAVED, I. and MUHAMMAD, F. (2013) Effect of vitamins, probiotics and protein level on semen traits and seminal plasma biochemical parameters of post-moult male broiler breeders. British Poultry Science 54 (1): 120-129.CrossRefGoogle ScholarPubMed
KHAN, R.U., RAHMAN, Z.U., NIKOUSEFAT, Z., JAVDANI, M., TUFARELLI, V., DARIO, C., SELVAGGI, M. and LAUDADIO, V. (2012a) Immunomodulating effects of vitamin E in broilers. World's Poultry Science Journal 68 (1): 31-40.CrossRefGoogle Scholar
KHAN, R.U., NAZ, S., JAVADANI, M., NIKOUSEFAT, Z., SELVAGGI, M., TUFARELLI, V. and LAUDADIO, V. (2012b) The use of turmeric (Curcuma longa) in poultry diets. World's Poultry Science Journal 68 (1): 97-103.Google Scholar
KITA, K., KATO, S., YAMAN, M.A., OKUMURA, J. and YOKOTA, H. (2002) Dietary L-carnitine increases plasma insulin-like growth factor-I concentration in chicks fed a diet with adequate dietary protein level. British Poultry Science 43: 117-121.Google Scholar
KITA, K., NAKAJIMA, S. and NAKAGAWA, J. (2005) Dietary L-carnitine supplementation improves albumen quality of laying hens. The Journal of Poultry Science 42: 79-83.Google Scholar
LIEN, T.F. and HORNG, Y.M. (2001) The effect of supplementary dietary L-carnitine on the growth performance, serum components, carcass traits and enzyme activities in relation to fatty acid beta-oxidation of broiler chickens. British Poultry Science 42: 92-95.Google Scholar
LIU, J., HEAD, E., KURATSUNE, H., COTMAN, C.W. and AMES, B.N. (2004) Comparison of the effects of L-carnitine and acetyl-l-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Annals of the New York Academy of Sciences 1033: 117-131.Google Scholar
MAST, J., BUYSE, J. and GODDEERIS, B.M. (2000) Dietary L-carnitine supplementation increases antigen-specific immunoglobulin G production in broiler chickens. British Journal of Nutrition 83: 161-166.Google Scholar
MONA, and YOUNIS, E.M. (2015) Influence of Dietary L-Carnitine on Productive Performance, Internal Organs and Carcass Characters of Two Duck Breeds Reared for Foie Gras Production. Alexandria Journal of Veterinary Sciences 44: 159-168.CrossRefGoogle Scholar
MICHALCZUK, M., LUKASIEWICZ, M., NIEMIEC, J., WNUK, A. and MROCZEK, S.N. (2012) Effect of L-carnitine on performance and dressing percentage of broiler chickens SGGW. Animal Science 51: 89-99.Google Scholar
MUTHUSWAMY, A.D., VEDAGIRI, K., GANESAN, M. and CHINNAKANNU, P. (2006) Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid. Clinica Chimica Acta 368: 84-92.CrossRefGoogle ScholarPubMed
NEUMAN, S.L., LIN, T.L. and HESTER, P.Y. (2002) The effect of dietary carnitine on semen traits of White Leghorn roosters. Poultry Science 81: 495-503.Google Scholar
NOFAL, M.E., SAMAK, H.R., MARIEY, Y.A. and MAHAMUD, R.M. (2006) Production performance and serum constituents of aged Gimizah hens as affected by dietary supplementation with L-carnitine. Egyptian Poultry Science 26: 1269-1283.Google Scholar
NOUBOUKPO, K.E., TONA, K., AGBONON, A., GBEASSOR, M., BUYSE, J. and DECUYPERE, E. (2010) Effects of L-carnitine supplementation in drinking water on layer-type chick juvenile performance. Archiv für Geflügelkunde 74: 116-120.Google Scholar
PARIZADIAN, B., AHANGARI, Y.J., SHAMS, M. and SARDARZADEH, A. (2011) Effects of different levels of L-carnitine supplementation on egg quality and blood parameters of laying Japanese quail. International Journal of Poultry Science 10: 621-625.Google Scholar
PARSAEIMEHR, K., AFROUZIYEH, M. and HOSEINZADEH, S. (2014) The Effects of L‐Carnitine and different levels of animal fat on performance, carcass characteristics, some blood parameters and immune response in broiler chicks. Iranian Journal of Applied Animal Science 4: 561-566.Google Scholar
RABIE, M.H., SZILAGYI, M. and GIPPERT, T. (1997a) Effects of dietary L-carnitine supplementation and protein level on performance and degree of meatiness and fatness of broilers. Acta Biologica Hungarica 48: 221-229.Google Scholar
RABIE, M.H., SZILAGYI, M., GIPPERT, T., VOTISKY, E. and GERENDAD, (1997b) Influence of dietary L-carnitine on performance and carcass quality of broiler chickens. Acta Biologica Hungarica 48: 241-252.Google Scholar
RABIE, M.H., SZILAGYI, M. and GIPPER, T. (1997c) Effects of dietary L-carnitine on the performance and egg quality of laying hens from 65-73 weeks of age. British Journal of Nutrition 78: 615-623.Google Scholar
RABIE, M.H. and SZILAGYI, M. (1998) Effects of L-carnitine supplementation of diets differing in energy levels on performance, abdominal fat content, and yield and composition of edible meat of broilers. British Journal of Nutrition 80: 391-400.Google Scholar
REZAEI, M., ATTAR, A., GHODRATNAMA, A. and KERMANSHAHI, H. (2007) Study the effects of different levels of fat and L-carnitine on performance, carcass characteristics and serum composition of broiler chicks. Pakistan Journal of Biological Sciences 10: 1970-1976.Google Scholar
REZAEI, M., DEHGHANI, S., GHAFFARI, J. and HAGHNAZAR, A. (2008) The effects of different levels of L-carnitine and fat on performance and egg quality of laying hens. Agricultural and Food Science 17: 360-366.Google Scholar
REZA, Y.M., SAEID, S.S. and JAVAD, N. (2015) The effects of different levels of L-Carnitine and methionine on immune response and some blood parameters in female broiler. Research Opinions in Animal & Veterinary Sciences 5: 94-98.Google Scholar
SARICA, S., CORDUK, M., ENSOY, U., BASMACIOGLU, H. and KARATAS, U. (2007) Effects of dietary supplementation of L-carnitine on performance, carcass and meat characteristics of quails. South African Journal of Animal Science 37: 189-201.Google Scholar
SARICA, S., CORDUK, M. and KILINC, K. (2005) The effect of dietary L-carnitine supplementation on growth performance, carcass traits, and composition of edible meat in Japanese quail (Coturnix coturnix japonica). Journal of Applied Poultry Research 14 (4): 709-715.Google Scholar
SONAIYA, E.B. (1985) Abdominal fat weight and thickness as predictors of total body fat in broilers. British Poultry Science 26: 453-458.Google Scholar
THIEMEL, J. and JELINEK, P. (2004) The effect of carnitine on hatching rate end metabolic profile of blood in breeding layers. Czech Journal Animal Science 49: 517-523.Google Scholar
TUFAN, T., ARSLAN, C., DURNA, Ö., ÖNK, K., SARI, M. and ERMAN, H. (2015) Effects of chito-oligosaccharides and L-carnitine supplementation in diets for Japanese quails on performance, carcass traits and some blood parameters. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia67: 283-289.Google Scholar
UELAND, T., SVARDAL, A., OIE, E., ASKEVOLD, E.T., NYMOEN, S.H., BJØRNDAL, B., DAHL, C.P., GULLESTAD, L., BERGE, R.K. and AUKRUST, P. (2013) Disturbed carnitine regulation in chronic heart failure - Increased plasma levels of palmitoyl-carnitine are associated with poor prognosis. International Journal of Cardiology 167: 1892-1899.CrossRefGoogle ScholarPubMed
WANG, Y.W., NING, D., PENG, Y.Z. and GUO, Y.M. (2013) Effects of Dietary L-carnitine Supplementation on Growth Performance, Organ Weight, Biochemical Parameters and Ascites Susceptibility in Broilers Reared Under Low-temperature Environment. Asian-Australasian Journal of Animal Science 26: 233-240.Google Scholar
XU, Z.R., WANG, M.Q., MAO, H.X., ZHAN, X.A. and HU, C.H. (2003) Effects of L-carnitine on growth performance, carcass composition, and metabolism of lipids in male broilers. Poultry Science 82: 408-413.Google Scholar
YOUSEFI, A., KHAJALI, F., HASSANPOUR, H. and KHAJALI, Z. (2013) Dietary L-carnitine improves pulmonary hypertensive response in broiler chickens subjected to hypobaric hypoxia. Journal of Poultry Science 50: 143-149.Google Scholar
ZHAI, W., NEUMAN, S., LATOUR, M.A. and HESTER, P.Y. (2008a) The effect of in ovo injection of L-carnitine on hatchability of white leghorns. Poultry Science 87: 569-572.Google Scholar
ZHAI, W., NEUMAN, S., LATOUR, M.A. and HESTER, P.Y. (2008b) The effect of male and female supplementation of L-carnitine on reproductive traits of white Leghorns. Poultry Science 87: 1171-1181.Google Scholar
ZHANG, Y., MA, Q., BAI, X., ZHAO, L., WANG, Q. and JI, C. (2010) Effects of dietary acetyl- L-carnitine on meat quality and lipid metabolism in Arbor Acres Broilers. Asian-Australasian Journal of Animal Science 23: 1639-1644.Google Scholar
ZHANG, Y., JIA, R., JI, C., MA, Q., HUANG, J., YIN, H. and LIU, L. (2014) Effects of dietary alpha-lipoic acid and acetyl-L-carnitine on growth performance and meat quality in Arbor Acres broilers. Asian-Australasian Journal of Animal Science 27: 996-1002.Google Scholar