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The Pantothenate-Synthesizing Enzyme, A Metabolic Site in the Herbicidal Action of Chlorinated Aliphatic Acids

Published online by Cambridge University Press:  12 June 2017

J. L. Hilton ,
J. S. Ard ,
L. L. Jansen  and
W. A. Gentner
J. L. Hilton
Affiliation:
Crops Research Division, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, Maryland
J. S. Ard
Affiliation:
Eastern Utilization Research and Development Division, Agricultural Research Service, U. S. Department of Agriculture, Philadelphia 18, Pennsylvania
L. L. Jansen
Affiliation:
Crops Research Division, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, Maryland
W. A. Gentner
Affiliation:
Crops Research Division, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, Maryland
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Extract

Evidence that β-alanine or calcium pantothenate partially reversed the inhibitory action of several chlorinated aliphatic acids on yeast growth (4) suggested the hypothesis that synthesis of pantothenate is one of the metabolic pathways sensitive to this group of herbicides. The objectives of the experiments reported herein were (a) to determine the mechanism by which the enzymatic synthesis of pantothenate was inhibited by these compounds, (b) to seek evidence for the contributions of this mechanism, in vivo, to the herbicidal effects of 2,2-dichloropropionic acid (dalapon), (c) to determine whether pantothenate treatments could overcome the effects of dalapon in plants and (d) to test chloro-substituted analogs of pantoate for herbicidal activity. To achieve the last objective it was necessary to synthesize several new chemicals.

Type
Research Article
Information
Weeds , Volume 7 , Issue 4 , October 1959 , pp. 381 - 396
Copyright
Copyright © 1959 Weed Science Society of America 

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References

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