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Inhibition of Pantothenate Biosynthesis by Substituted Benzoic Acids

Published online by Cambridge University Press:  12 June 2017

J. L. Hilton
J. L. Hilton*
Affiliation:
Crops Research Division, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, Maryland
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Abstract

Several ring-substituted derivatives of benzoic acid inhibited pantothenate biosynthesis in Escherichia coli. The metabolic site of inhibition was the conversion of ketopantoate to pantoate. This action caused pantothenate-reversible reductions in growth only in strains of E. coli with inherent limited capacities for biosynthesis of ketopantoate. Inhibition of pantothenate biosynthesis was tentatively concluded to be of little physiological significance as a site of action responsible for herbicidal activities of benzoic acids.

Type
Research Article
Information
Weeds , Volume 13 , Issue 3 , July 1965 , pp. 267 - 271
Copyright
Copyright © 1965 Weed Science Society of America 

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References

Literature Cited

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