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Aliphatic Acid Inhibitors: Interference with Ketopantoate Utilization for Pantothenate Biosynthesis

Published online by Cambridge University Press:  12 June 2017

J. L. Hilton
J. L. Hilton*
Affiliation:
Crops Research Division, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, Maryland
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Abstract

Propionate, 3-chloropropionate, and 2,2-dichloropropionate (dalapon) inhibited growth of Escherichia coli 99-4, a mutant organism incapable of growth in the absence of α-ketopantoate. Growth inhibitions were circumvented by increasing the concentration of ketopantoate. Aliphatic acids (K+ salts) apparently inhibit biosynthesis of pantothenate at two metabolic sites—conversion of ketopantoate to pantoate and formation of pantothenate from pantoate. The latter inhibition has been reported previously.

Type
Brief Papers
Information
Weeds , Volume 14 , Issue 2 , April 1966 , pp. 174 - 176
Copyright
Copyright © 1966 Weed Science Society of America 

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References

Literature Cited

1. Hilton, J. L. 1965. Inhibition of pantothenate biosynthesis b) substituted benzoic acids. Weeds 13:267–271.Google Scholar
2. Hilton, J. L., Ard, J. S., Jansen, L. L., and Gentner, W. A. 1959. The pantothenate-synthesizing enzyme, a metabolic site in the herbicidal action of chlorinated aliphatic acids. Weeds 7:381–396.Google Scholar
3. Hilton, J. L., Jansen, L. L., and Gentner, W. A. 1958. Beta-alanine protection of yeast growth against the inhibitory action of several chlorinated aliphatic acid herbicides. Plant Physiol. 33:43–45.CrossRefGoogle ScholarPubMed
4. Van Oorschot, J. L. P., and Hilton, J. L. 1963. Effect of chlorosubstitution on aliphatic acid inhibitors of pantothenate metabolism in Escherichia coli . Arch. Biochem. Biophys. 100:289–294.Google Scholar