Quackgrass (Agropyron repens) is a weed of major importance in the northern regions of the United States where cool, humid climatic conditions prevail. In the areas of Wisconsin having a heavy red clay soil, the weed is especially troublesome for the soil characteristics hinder the most effective use of cultural control measures. The fact that quackgrass can be found on the majority of the farms in northern Wisconsin is evidence that effective methods of quackgrass control are not being used. The question arises of whether generally recommended methods of quackgrass control are effective under the conditions prevalent in this area. The present study describes the results obtained during 1947 and 1948 at the Ashland Branch Experiment Station using several combinations of tillage, cropping and fertilization. An attempt was also made to compare the value of two methods of estimating quackgrass infestations.