In Iran, monochoria is a noxious weed in fields of transplanted rice. Two field experiments were conducted to assess the efficacy of soil-applied and foliar-applied herbicides to control monochoria in transplanted rice. Prepackaged herbicides (triafamone plus ethoxysulfuron applied at 40 g ai ha−1, pyrazosulfuron-ethyl plus pretilachlor applied at 382.5 g ai ha−1, and pendimethalin plus clomazone applied at 1,200 g ai ha−1) reduced monochoria biomass by 100%, 100%, and 14%, respectively; and a single application of flucetosulfuron at 30 g ai ha−1, pendimethalin at 990 g ai ha−1, thiobencarb at 2,750 g ai ha−1, and pretilachlor at 1,000 g ai ha−1 reduced monochoria biomass by 100%, 99%, 75%, and 56%, respectively, compared with a nontreated control. Tank-mixed bensulfuron-methyl at 45 g ai ha−1 applied with pretilachlor, thiobencarb, or pendimethalin provided 100% control of monochoria. Rice height, and straw and grain yield were greater after herbicide treatments than those of the nontreated and hand-weeded controls, indicating the advantages of chemical control of monochoria over manual weeding. Full-season monochoria interference reduced rice grain yield by 32%. In the second study, the herbicides triafamone plus ethoxysulfuron, flucetosulfuron, 2,4-D at 1,080 g ai ha−1, dicamba plus 2,4-D at 928 g ai ha−1, bispyribac-sodium at 31.25 g ai ha−1, bentazon plus MCPA at 1,150 g ai ha−1, pyribenzoxim at 30 g ai ha−1, and propanil at 5,400 g ai ha−1 applied to foliage at 4- to 5-leaf seedlings of monochoria provided ≥97% control and prevented 100% of its regrowth, with the exception of propanil. This study shows that monochoria control can be achieved by using a variety of residual and foliar-applied herbicides with different mechanisms of action.