Florpyrauxifen-benzyl is a postemergence (POST) rice herbicide that has reduced rice yield in some situations, and producers are concerned that the impact could be even greater with low rice seeding densities. Therefore, research was conducted in Stoneville, MS, from 2019 to 2021 to evaluate the effect of florpyrauxifen-benzyl on rice yield when a hybrid was seeded at reduced densities. Hybrid rice ‘RT 7521 FP’ was seeded at 10, 17, 24, 30, and 37 kg ha-1. At the four-leaf to one-tiller growth stage, florpyrauxifen-benzyl was applied at 0 or 59 g ai ha-1. Rice injury following the application of florpyrauxifen-benzyl was ≤ 8% across all seeding rates and evaluation intervals. Application of florpyrauxifen-benzyl reduced plant heights by 14% across all seeding rates but did not result in delayed rice maturity. When florpyrauxifen-benzyl was not applied rice in the 10 and 17 kg ha-1 seeding rates, rice matured slower than when seeded at 24, 30, and 37 kg ha-1. When florpyrauxifen-benzyl was applied, rough rice grain yields were reduced by 17 and 37 kg ha-1 but not at any other seeding rate. In conclusion, the application of florpyrauxifen-benzyl at a 2x rate can cause a loss of yield resulting from variation in rice densities.