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Epidemiology and Toxicology of 2,4-D

Published online by Cambridge University Press:  12 June 2017

Wendell R. Mullison
Affiliation:
Midland, MI 48640
Gregory G. Bond
Affiliation:
Health & Environmental Sciences, Dow Chemical Co., Midland, MI 48674

Extract

The herbicide 2,4-D has been in commerce and a subject for research since 1944. It is undoubtedly among the most thoroughly researched pesticides in the world. In our society, 2,4-D has played an indispensable role. It is most important in the production of our food and fiber; in the control of noxious weeds causing public health problems such as common ragweed (Ambrosia artemisiifolia L.) and poison-ivy [Toxicodendron radicans (L.) Ktze.] in the maintenance of our utility supply lines and highway and railroad systems; and as a useful tool for creating desirable wildlife habitats and beautifying our parks, golf courses, and the grounds about our homes.

Recently completed toxicological studies support the conclusions of earlier studies that 2,4-D may be used without undue risk to man, wildlife, or the environment. This does not mean, of course, that we should lessen our precautions to avoid exposure to applicators, prevent spray drift from getting on bystanders, or on pets such as dogs and cats, and following general good sanitation practices in its use.

There have been some reports of an association between the use of 2,4-D and NHL. However, in our opinion after considering all the toxicological and epidemiological evidence, it has not been established that the use of 2,4-D causes NHL or any other type of cancer including soft tissue sarcomas and Hodgkin's disease. As cited in this review, most scientific experts who have carefully examined all the data share this opinion.

Type
Editorial/Mini-Review
Copyright
Copyright © 1990 by the Weed Science Society of America 

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References

Literature Cited

1. Axelson, O., Sundell, L., Anderson, K. et al. 1980. Herbicide exposure and tumor mortality. An updated epidemiologic investigation on Swedish railroad workers. Scand. J. Workers Environ. Health. 6:7379.CrossRefGoogle ScholarPubMed
2. Bjorklund, N. E., and Erne, K. 1966. Toxicological studies of phenoxyacetic herbicides in animals. Vet. Bry. Scand. 7:364390.Google Scholar
3. Blakely, B. R., and Schiefer, B. H. 1986. The effect of topically applied N-butyl ester of 2,4-dichlorophenoxyacetic acid on the immune response in mice. J. Appl. Toxicol. 6:291295.Google Scholar
4. Blakely, B. R. 1986. The effect of oral exposure to the N-butyl ester of 2,4-dichlorophenoxyacetic acid on the immune response in mice. Int. J. Immunopharmacol. 8:9399.CrossRefGoogle Scholar
5. Bond, G. G., Wetterstrom, N. H., and Roush, G. I. 1988. Cause-specific mortality among employees engaged in the manufacture, formulation or packaging of 2,4-dichlorophenoxyacetic acid and related salts. Br. J. Ind. Med. 45:98105.Google Scholar
6. Bond, G. G., Bodner, K. M., and Cook, R. R. 1989. Phenoxy herbicides and cancer: insufficient epidemiological evidence for a causal relationship. Fund. Appl. Toxicol. 12:172188.Google Scholar
7. Cantor, K. P., and Blair, A. 1986. Agricultural chemicals, drinking water, and public health: An epidemiologic overview. Soil Science Society Workshop. Paper No. 2. Soil Sci. Soc. Am. Madison, WI.Google Scholar
8. CAST. 1987. Perspectives on the safety of 2,4-D. Council for Agricultural Science and Technology. p. 16.Google Scholar
9. Coggin, D., and Acheson, E. D. 1982. Do phenoxy herbicides cause cancer in man. Lancet 1:1057.Google Scholar
10. Coombs, J. 1988. The agent orange phenomena: The report of the Australian Royal Commission. Chapter 14 in agent orange and its associated dioxin: assessment of a controversy by A. L. Young and G. M. Reggiani. Elsevier Publishing Co., New York.Google Scholar
11. Coulton, T. 1986. Herbicide exposure and cancer. JAMA 256:11761178.Google Scholar
12. EPA. 1988. Pesticide Fact Sheet: 2,4-Dichlorophenoxyacetic Acid (2,4-D). Fact Sheet No. 94.2.Google Scholar
13. Eriksson, M., Hardell, L., Berg, O. N. et al. 1981. Soft-tissue sarcomas and exposure to chemical substances. A case-referent study. Br. J. Ind. Med. 38:2733.Google Scholar
14. Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel Report. 1987 on A Set of Scientific Issues Being Considered by the Agency in Connection with the Peer Review Classification of 2,4-D as a Class C Oncogen. Letter Report by S. L. Johnson, Executive Secretary July 8.Google Scholar
15. Feldmann, R. F., and Maibach, H. I. 1974. Percutaneous penetration of some pesticides and herbicides in man. Toxicol. Appl. Pharmacol. 28:126132.Google Scholar
16. Frank, R., Campbell, R. A., and Sirons, G. J. 1985. Forestry workers involved in aerial application of 2,4-dichlorophenoxyacetic acid (2,4-D): exposure and urinary excretion. Arch. Environ. Contamin. Toxicol. 14:457–435.Google Scholar
17. Gehring, P. J., and Betso, J. E. 1978. Phenoxy acids: effects and fate in mammals in chlorinated phenoxy acids and their dioxins. Ramel, C. (ed.) Ecological Bulletin (Stockholm) NFR 27:122133.Google Scholar
18. Green, L. M. 1986. Mortality Analysis of Ontario Hydro Forestry Tradesmen Cohort 1950–1982. Health Services Department, Health Services Department, Health and Safety Division, Ontario Hydro, Toronto, ON, Can. Google Scholar
19. Grover, R., Cessna, A. J., Muir, N. I., Riedel, D., Franklin, C. A., and Yoshida, K. 1986. Factors affecting the exposure of ground-rig applicators to 2,4-D dimethylamine salt. Arch. Environ. Contamin. and Toxicol. 15:677686.Google Scholar
20. Hanson, W. H., Quaife, M. L., Habermann, R. T., and Fitzhugh, O. G. 1971. Chronic toxicity of 2,4-dichlorophenoxyacetic acid in rats and dogs. Toxicol. Appl. Pharm. 20:122129.Google Scholar
21. Hardell, L. 1977. Soft-tissue sarcomas and exposure to phenoxy acids: A clinical observation. Lancet. 74:27532754.Google Scholar
22. Hardell, L. 1979. Malignant lymphomas of histiocytic type and exposure to phenoxyacetic acids or chlorophenols. Lancet. 1:5556.Google Scholar
23. Hardell, L. 1980. Cross-examination Before the Environmental Protection Agency. FIFRA Docket Nos. 4115ff Exhibit 773. September 29.Google Scholar
24. Hardell, L. 1981. Relation of soft-tissue sarcomas, malignant lymphoma and colon cancer to phenoxy acids, chlorophenols and other agents. Scand. J. Work Environ. Health. 7:119130.CrossRefGoogle ScholarPubMed
25. Hardell, L., and Sandstrom, A. 1979. Case-control study: soft tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols. Br. J. Cancer. 39:711717.CrossRefGoogle ScholarPubMed
26. Hardell, L., Eriksson, M., Lenner, P., and Lundgreen, E. 1981. Malignant lymphoma and exposure to chemicals especially organic solvents, chlorophenols and phenoxy acids: A case-control study. Br. J. Cancer 43:169176.Google Scholar
27. Harris, S., Bowley, C., Solomon, K. R., and Stephenson, G. R. 1990. Exposure studies in the use of pesticides in the home garden and for landscape pest control. Res. Progr. Rep. May 2, 1990. Can. Centre for Toxicol. and Dep. Environ Biol., Univ. Guelph. Google Scholar
28. Harvard School of Public Health. 1990. The Weight of the Evidence on the Human Carcinogenicity of 2,4-D. Final Report. 65 p. Harvard School of Public Health, 677 Huntington Avenue, Boston, MA. 02115.Google Scholar
29. Hoar, S. K., Blair, A., Holmes, F. F., Boysen, C. D., Robel, R. J., Hoover, R., and Fraumeni, J. F. 1986. Agricultural herbicide use and risk of lymphomas and soft tissue sarcoma. J. Am. Med. Assoc. 256:11411147.Google Scholar
30. Hoar-Zahm, S. H., Weisenburger, D. D., Babbitt, P. A., Saal, R. C., Vaught, J. B., Cantor, K. P., and Blair, A. 1990. A case-control study of non-Hodgkin's lymphoma and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) in eastern Nebraska. Epidemiology 1:349356.CrossRefGoogle Scholar
31. Hoar-Zahm, S. H., Weisenburger, D. D., Ward, M., Babbitt, P. A., Holmes, F. F., Boysen, C. D., Robel, R. J., Saal, R., Vaught, J. B., and Blair, A. 1990. Agricultural pesticide use and non-Hodgkin's lymphoma in the Midwestern United States. Abstr. p. 349, 23rd International Congress on Occupational Health, Montreal, Can. Sept. 22–28, p. 349.Google Scholar
32. Hogstedt, C., and Westerlund, B. 1980. Cohort studies of cause of death of forest workers with and without exposure to phenoxy acid preparations. Lakartidningen. 77:18281831.Google Scholar
33. Innes, J.R.M., Ulland, B. M., Valerio, M. G., et al. 1969. Bioassay of pesticides and industrial chemicals for tumorgenicity in mice: a preliminary note. J. Nat. Cancer Inst. 42:11011114.Google Scholar
34. Kogevinas, M. 1990. The IARC International Register of Persons Exposed to Phenoxy Herbicides, First Results. Abstr. 23rd International Congress on Occupational Health. Montreal, Can. Sept. 22–28. p. 348.Google Scholar
35. Lavy, T. L., Walstad, J. D., Flynn, R. R., and Mattice, J. D. 1982. (2,4-dichlorophenoxy)acetic acid exposure received by aerial application crews during forest spray operations. J. Agric. Food Chem. 30:375381.Google Scholar
36. Lavy, T. L., Norris, L. A., Mattice, J. D., and Marx, D. B. 1987. Exposure of forestry ground workers to 2,4-D, picloram and dichlorprop. Environ. Toxicol. Chem. 6:209224.Google Scholar
37. Libich, S., To, J. C., Frank, R., and Sirons, G. J. 1984. Occupational exposure of herbicide applicators to herbicides used along electric power transmission line right-of-way. Am. Ind. Hygiene Assoc. J. 45:5662.Google Scholar
38. Linet, M. S. 1986. Review of “Agricultural herbicide use and risk of lymphoma and soft tissue sarcoma” by S. Hoar, K., Blair, A., Homes, F. F., et al. and Other epidemiologic studies examining the association between the herbicide 2,4-D, herbicides in general, farming and malignant lymphoma. Prepared for the Environmental Protection Agency, October 17.Google Scholar
39. Lynge, E. 1985. A follow-up study of cancer incidence among workers in manufacture of phenoxy herbicides in Denmark. Br. J. Cancer. 52:259270.Google Scholar
40. MacMahon, B. 1986. Review of Hoar et al. and related literature for EPA P.D. #6W-3948-NASA. Sept. 29, 1986.Google Scholar
41. Mattsson, J. L., Johnson, K. A. and Albee, R. R. 1986. Lack of neuropathological consequences of repeated dermal exposure to 2,4-dichlorophenoxyacetic acid in rats. Fund. Appl. Toxicol. 6:175181.Google Scholar
42. Mitchell, J. W. and Hamner, C. L. 1944. Polyethylene glycols as carriers for growth regulating substances. Bot. Gaz. 105:474483.CrossRefGoogle Scholar
43. Mullison, W. R. 1981. Public concerns about the herbicide 2,4-D. Proc. West. Soc. Weed Sci. 34:154193.Google Scholar
44. Mullison, W. R. 1986. An Interim Report Summarizing 2,4-D toxicological research and a brief review of 2,4-D environmental effects. Industrial Task Force On 2,4-D Research Data, McKenna, Connor & Cuneo, 1575 Eye Street, Washington, DC 20005.Google Scholar
45. Monro, I. C. et al. 1987. Expert panel report on carcinogenicity of 2,4-D. Canadian Centre for Toxicology, Guelph, ON, Can. Google Scholar
46. Nash, R. G., Kearney, P. C., Maitlen, J. C., Sell, C. R., and Fertig, S. N. 1982. Agricultural applicators exposure to 2,4-dichlorophenoxyacetic acid. In pesticide residues and exposure A. C. S. Symp. Ser. Plimmer, J. R., ed. 182, p. 119132.Google Scholar
47. National Research Council of Canada, Associate Committee on Scientific Criteria for Environmental Quality. 1978. Phenoxy herbicides–their effects on environmental quality with accompanying scientific criteria for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Nat. Res. Counc. of Can. p. 440.Google Scholar
48. Palmer, J. S., and Radeleff, R. D. 1969. The toxicity of some organic herbicides to cattle, sheep and chickens. Prod. Res. Rep. No. 106 Agric. Res. Serv., U.S. Dep. Agric. Google Scholar
49. Pearce, N. E., Smith, A. H., Sheppard, R. A. et al. 1986. Non-Hodgkin's lymphoma and exposure to phenoxyherbicides, chlorophenols, fencing work, and meat works employment: A case-control study. Br. J. Ind. Med. 43:7583.Google Scholar
50. Pearce, N. E. 1989. Phenoxy herbicides and non-Hodgkin's lymphoma in New Zealand: frequency and duration of herbicide use. Br. J. Ind. Med. 46:143144.Google ScholarPubMed
51. Riihimaki, V., Asp, S., and Hernberg, S. 1982. Mortality of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid herbicide applicators in Finland. Scand. J. Work Environ. Health. 8:3742.CrossRefGoogle ScholarPubMed
52. Serota, D. G. 1986. Combined toxicity and oncogenicity study in rats, 2,4-dichlorophenoxyacetic acid. Final Report. Hazelton Laboratories, America, Inc. Vienna, VA. p. 2039.Google Scholar
53. Serota, D. G. 1987. Oncogenicity study in mice, 2,4-dichlorophenoxyacetic acid. Final Report. Hazelton Laboratories, America, Inc. Vienna, VA. p. 1797.Google Scholar
54. Smith, A. H., and Pearce, N. E. 1986. Update on soft-tissue sarcoma and phenoxyherbicides in New Zealand. Chemosphere 15:17951798.Google Scholar
55. Smith, A. H., Pearce, N. E., Fisher, O. D. et al. 1984. Soft-tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand. J. Nat. Cancer Inst. 73:11111117.Google Scholar
56. Thompson, D. G., Stephenson, G. R., and Sears, M. K. 1986. Persistence, distribution and dislodgeable residue of 2,4-D following its application to turfgrass. Pestic. Sci. 15:353360.Google Scholar
57. Toyoshima, E., Moyer, R. F., Max, S. R., and Eccles, C. 1985. 2,4-Dichlorophenoxyacetic acid (2,4-D) does not cause polyneuropathy in the rat. J. Neuro. Sci. 70:225229.Google Scholar
58. Wiklund, K., Dich, J., and Holm, L. 1987. Risk of malignant lymphoma in Swedish applicators. Br. J. Cancer. 56:505508.Google Scholar
59. Wiklund, K., Dich, J., and Holm, L. 1988. Soft tissue sarcoma risk in Swedish licensed pesticide applicators. J. Occup. Med. 30:801804.Google Scholar
60. Woods, J. S., Polissar, L., Severson, R. K. 1987. Soft tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxy herbicide and chlorophenol exposure in western Washington. J. Nat. Cancer Inst. 78:899910.Google Scholar
61. World Health Organization. 1984. Environmental Health Criteria 29–2,4-Dichlorophenoxyacetic Acid (2,4-D) World Health Organization, Geneva, Switzerland. p. 151.Google Scholar
62. Yeary, R. A. 1986. Urinary excretion of 2,4-D in commercial lawn specialists. Appl. Ind. Hygiene. 1:1191201.Google Scholar