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Spatial geometry of the dopamine innervation in the avascular area of the human fovea

Published online by Cambridge University Press:  02 June 2009

Claudine Savy ,
Axelle Simon  and
Jeanine Nguyen-Legros
Claudine Savy
Affiliation:
Laboratoire de Neurocytologie Oculaire (INSERM U-86), 15, rue de l' Ecole de Médecine, 75270, Paris06, France
Axelle Simon
Affiliation:
Laboratoire de Neurocytologie Oculaire (INSERM U-86), 15, rue de l' Ecole de Médecine, 75270, Paris06, France
Jeanine Nguyen-Legros
Affiliation:
Laboratoire de Neurocytologie Oculaire (INSERM U-86), 15, rue de l' Ecole de Médecine, 75270, Paris06, France
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Abstract

The dopamine (DA) innervation, labeled by tyrosine hydroxylase immunohistochemistry in a wholemounted human retina, is described in the avascular area of the fovea. Eleven DA neurons give rise to this innervation, among which five are interplexiform cells, so that the DA innervation consists of two plexuses: one is internal and is formed by the dendrites of all of the DA cells, and the other is external and is formed by the scleral processes of the interplexiform cells. Five concentric zones are delineated according to the focal plane in which the internal DA plexus is observed. The central zone 1 contains DA processes crossing in all directions. Zones 2 and 3 do not contain any cell bodies. In zone 3 the internal plexus begins to undergo a concentric arrangement, which is clearly observed in zones 4 and 5. The external DA innervation displays a different appearance in zones 1, 2, and 3, in which it consists of vertically oriented thin processes and terminals penetrating the outer nuclear layer, vs. zones 4 and 5 in which it consists of both the same type and horizontal processes lying in the outer plexiform layer. On the basis of DA-innervation appearance and distribution of labeled and unlabeled cell somata, it was concluded that zones 1, 2, and 3 contained the DA innervation of the foveola. DA processes filtering between photoreceptor cells are particularly well-observed in this region. This anatomical study of the DA innervation in the human fovea leads to a better understanding of the important role of DA in primate central vision and can be used as a reference for an approach of macular pathology.

Keywords

RetinaDopamineHumanFoveaTopology
Type
Research Articles
Information
Visual Neuroscience , Volume 7 , Issue 5 , November 1991 , pp. 487 - 498
Copyright
Copyright © Cambridge University Press 1991

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