Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-23T07:01:06.012Z Has data issue: false hasContentIssue false
  • English
  • Français

Platelet-derived growth factor (PDGF) receptors in the developing mouse optic pathway

Published online by Cambridge University Press:  02 June 2009

James B. Hutchins  and
Xiaorong Zhang
James B. Hutchins
Affiliation:
Departments of Anatomy and Neurology, University of Mississippi Medical Center, Jackson
Xiaorong Zhang
Affiliation:
Department of Anatomy, University of Mississippi Medical Center, Jackson
Get access Rights & Permissions [Opens in a new window]

Abstract

The molecules which control the patterns of cell division, growth, and precise interconnections characteristic of the central nervous system still remain largely unidentified. The protein platelet-derived growth factor (PDGF) has been shown to mediate interactions among glial cells in vitro. More recent evidence has indicated that PDGF may also be involved in controlling communication between neurons and glial cells and among neurons. The presence of receptors for PDGF on neurons of the developing nervous system is an essential piece of evidence in this chain of events. Ganglion cells are labeled with antibodies to PDGF receptor only during the period of active process outgrowth. These findings suggest that PDGF is used as a mediator of intercellular signaling during neuronal development.

Keywords

Proto-oncogenesRetinaOptic nerveOptic chiasmTyrosine kinases
Type
Research Articles
Information
Visual Neuroscience , Volume 11 , Issue 1 , January 1994 , pp. 33 - 40
Copyright
Copyright © Cambridge University Press 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72, 248–254.CrossRefGoogle ScholarPubMed
Brewitt, B. & Clark, J.I. (1988). Growth and transparency in the lens, an epithelial tissue, stimulated by pulses of PDGF. Science 242, 777–779.CrossRefGoogle ScholarPubMed
Burridge, K., Fath, K., Kelly, T., Nuckolls, G. & Turner, C. (1988). Focal adhesions: Transmembrane junctions between the extracellular matrix and the cytoskeleton. Annual Review of Cell Biology 4, 487–525.CrossRefGoogle ScholarPubMed
Campochlaro, P.A. & Glaser, B.M. (1986). Mechanisms involved in retinal pigment epithelial cell chemotaxis. Archives of Ophthalmology 104, 277–280.CrossRefGoogle Scholar
Claesson-Welsh, L., Eriksson, A., Morén, A., Severinsson, L., Ek, B., Östman, A., Betsholtz, C. & Heldin, C.-H. (1988). cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Molecular and Cellular Biology 8, 3476–3486.Google ScholarPubMed
Claesson-Welsh, L., Eriksson, A., Westermark, B. & Heldin, C.-H. (1989). cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. Proceedings of the National Academy of Sciences of the U.S.A. 86, 4917–4921.CrossRefGoogle Scholar
Claesson-Welsh, L. (1993). PDGF receptors: Structure and mechanism of action. Cytokines 5, 31–43.Google Scholar
Deuel, T.F. (1987). Polypeptide growth factors: Roles in normal and abnormal cell growth. Annual Review of Cell Biology 3, 443–492.CrossRefGoogle ScholarPubMed
Diliberto, P.A., Bernacki, S.H. & Herman, B. (1990). Interrelationships of platelet-derived growth factor isoform-induced changes in c-fos expression, intracellular free calcium, and mitogenesis. Journal of Cellular Biochemistry 44, 39–53.CrossRefGoogle ScholarPubMed
Dräger, U.C. (1985). Birth dates of retinal ganglion cells giving rise to the crossed and uncrossed optic projections in the mouse. Proceedings of the Royal Society B (London) 224, 57–77.Google Scholar
Edwards, M.A., Schneider, G.E. & Caviness, V.S. Jr, (1986). Development of the crossed retinocollicular projection in the mouse. Journal of Comparative Neurology 248, 410–421.CrossRefGoogle ScholarPubMed
Eriksson, A., Siegbahn, A., Westermark, B., Heldin, C.-H. & Claesson-Welsh, L. (1992). PDGF α-and β-receptors activate unique and common signal transduction pathways. EMBO Journal 11, 543–550.CrossRefGoogle ScholarPubMed
Escobedo, J.A., Navankasatussas, S., Cousens, L.S., Coughlin, S.R., Bell, G.I. & Williams, L.T. (1988). A common PDGF receptor is activated by homodimeric A and B forms of PDGF. Science 240, 1532–1534.CrossRefGoogle Scholar
Ffrench-Constant, C., Miller, R.H., Burne, J.F. & Raff, M.C. (1988). Evidence that migratory oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells are kept out of the rat retina by a barrier at the eye-end of the optic nerve. Journal of Neurocytology 17, 13–25.CrossRefGoogle ScholarPubMed
Fulton, B.P., Burne, J.F. & Raff, M.C. (1991). Glial cells in the rat optic nerve. The search for the type-2 astrocyte. Annals of the New York Academy of Sciences 633, 27–34.CrossRefGoogle ScholarPubMed
Gronwald, R.G.K., Grant, F.J., Haldeman, B.A., Hart, C.E., O’Hara, P.J., Hagen, F.S., Ross, R., Bowen-Pope, D. & Murray, M.J. (1988). Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: Evidence for more than one receptor class. Proceedings of the National Academy of Sciences of the U.S.A. 85, 3435–3439.CrossRefGoogle ScholarPubMed
Hart, C.E., Forstrom, J.W., Kelly, J.D., Seifert, R.A., Smith, R.A., Ross, R., Murray, M.J. & Bowen-Pope, D.F. (1988). Two classes of PDGF receptor recognize different isoforms of PDGF. Science 240, 1529–1531.CrossRefGoogle ScholarPubMed
Herman, B., Roe, M.W., Harris, C., Wray, B. & Clemmons, D. (1987). Platelet-derived growth factor-induced alterations in vinculin distribution in porcine vascular smooth muscle cells. Cell Motility and the Cytoskeleton 8, 91–105.CrossRefGoogle ScholarPubMed
Herman, B. & Pledger, W.J. (1985). Platelet-derived growth factor-induced alterations in vinculin and actin distribution in BALB/ C-3T3 cells. Journal of Cell Biology 100, 1031–1040.CrossRefGoogle ScholarPubMed
Hutchins, J.B. & Ard, M.D. (1993). Platelet-derived growth factor receptor expression in rat neuronal and astroglial cultures. Molecular and Cellular Neurosciences 4, 250–258.CrossRefGoogle ScholarPubMed
Hutchins, J.B. & Jefferson, V.E. (1992). Developmental distribution of platelet-derived growth factor in the mouse central nervous system. Developmental Brain Research 67, 121–135.CrossRefGoogle ScholarPubMed
Jhaveri, S., Edwards, M.A. & Schneider, G.E. (1991). Initial stages of retinofugal axon development in the hamster: Evidence for two distinct modes of growth. Experimental Brain Research 87, 371–382.CrossRefGoogle ScholarPubMed
Kenton, P., Johnson, P.M. & Webb, P.D. (1989). The phosphorylation of p68, a calcium-binding protein associated with the human syncytiotrophoblast submembranous cytoskeleton, is modulated by growth factors, activators of protein kinase C and cyclic AMP. Biochimica et Biophysica Acta 1014, 271–281.CrossRefGoogle ScholarPubMed
Knorr, M., Hoppe, J., Steuhl, K.P. & Dartsch, P.C. (1992). Effect of PDGF-AB heterodimer on a corneal epithelial cell line. European Journal of Cell Biology 57, 202–209.Google ScholarPubMed
Lankford, K., Cypher, C. & Letourneau, P. (1990). Nerve growth cone motility. Current Opinion in Cell Biology 2, 80–85.CrossRefGoogle ScholarPubMed
Levine, J.M. (1989). Neuronal influences on glial progenitor cell development. Neuron 3, 103–113.CrossRefGoogle ScholarPubMed
Mellström, K., Hoglund, A.S., Nistér, M., Heldin, C.H. & Westermark, B. (1983). The effect of platelet-derived growth factor on morphology and motility of human glial cells. Journal of Muscle Research and Cell Motility 4, 589–609.CrossRefGoogle Scholar
Pei, Y.F. & Rhodin, J.A.G. (1970). The prenatal development of the mouse eye. Anatomical Record 168, 105–126.CrossRefGoogle ScholarPubMed
Pringle, N., Collarini, E.J., Hart, I.K., Raff, M.C. & Richardson, W.D. (1991). Platelet-derived growth factor in central nervous system gliogenesis. Annals of the New York Academy of Sciences 633, 160–168.CrossRefGoogle ScholarPubMed
Pringle, N.P., Mudhar, H.S., Collarini, E.J. & Richardson, W.D. (1992). PDGF receptors in the rat CNS: During late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. Development 115, 535–551.CrossRefGoogle ScholarPubMed
Reddy, U.R. & Pleasure, D. (1992). Expression of platelet-derived growth factor (PDGF) and PDGF receptor genes in the developing rat brain. Journal of Neuroscience Research 31, 670–677.CrossRefGoogle ScholarPubMed
Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D. & Hall, A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401–410.CrossRefGoogle ScholarPubMed
Ridley, A.J. & Hall, A. (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389–399.CrossRefGoogle ScholarPubMed
Robinson, S.R. & Dreher, B. (1990). The visual pathways of eutherian mammals and marsupials develop according to a common timetable. Brain, Behavior, and Evolution 36, 177–195.CrossRefGoogle ScholarPubMed
Ross, R., Raines, E.W. & Bowen-Pope, D.F. (1986). The biology of platelet-derived growth factor. Cell 46, 155–169.CrossRefGoogle ScholarPubMed
Sasahara, A., Kott, J.N., Sasahara, M., Raines, E.W., Ross, R. & Westrum, L.E. (1992). Platelet-derived growth factor B-chain-like immunoreactivity in the developing and adult rat brain. Developmental Brain Research 68, 41–53.CrossRefGoogle ScholarPubMed
Sasahara, M., Fries, J.W.U., Raines, E.W., Gown, A.M., Westrum, L.E., Frosch, M.P., Bonthron, D.T., Ross, R. & Collins, T. (1991). PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Cell 64, 217–227.CrossRefGoogle Scholar
Shaw, J.P., Chou, I.N. & Anand, B. (1988). Rapid phosphorylation of microtubule-associated proteins through distinct mitogenic pathways. Journal of Biological Chemistry 263, 1459–1466.CrossRefGoogle ScholarPubMed
Sidman, R.L. (1961). Histogenesis of mouse retina studied with thymi-dine-H3. In The Structure of the Eye, ed. Smelser, G.K., pp. 487–505. New York: Academic Press.Google Scholar
Silver, J. & Sapiro, J. (1981). Axonal guidance during development of the optic nerve: The role of pigmented epithelia and other extrinsic factors. Journal of Comparative Neurology 202, 521–538.CrossRefGoogle ScholarPubMed
Smits, A., Kato, M., Westermark, B., Nistér, M., Heldin, C.-H. & Funa, K. (1991). Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF β-type receptors and respond to PDGF. Proceedings of the National Academy of Sciences of the U.S.A. 88, 8159–8163.CrossRefGoogle ScholarPubMed
Theiler, K. (1989). The House Mouse: Atlas of Embryonic Development. New York: Springer-Verlag.CrossRefGoogle Scholar
Thyberg, J., Palmberg, L., Nilsson, J., Ksiazek, T. & Sjolund, M. (1983). Phenotype modulation in primary cultures of arterial smooth muscle cells. On the role of platelet-derived growth factor. Differentiation 25, 156–167.CrossRefGoogle ScholarPubMed
Tucker, R.W. (1983). Role of microtubules and centrioles in growth regulation of mammalian cells. Cell and Muscle Motility 3, 259–295.CrossRefGoogle ScholarPubMed
Tucker, R.W., Meade-Cobun, K. & Ferris, D. (1990). Cell shape and increased free cytosolic calcium [Ca2+]i induced by growth factors. Cell Calcium 11, 201–209.CrossRefGoogle ScholarPubMed
Van Gansen, P., Siebertz, B., Capone, B. & Malherbe, L. (1984). Relationships between cytoplasmic microtubular complex, DNA synthesis and cell morphology in mouse embryonic fibroblasts (effects of age serum deprivation, aphidicolin, cytochalasin B and colchicine). Biology of the Cell 52, 161–174.CrossRefGoogle ScholarPubMed
Waterfield, M.D., Scrace, G.T., Whittle, N., Stroobant, P., Johnsson, A., Wasteson, Á., Westermark, B., Heldin, C.-H., Huang, J.S. & Deuel, T.F. (1983). Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 304, 35–39.CrossRefGoogle Scholar
Westermark, B. (1990). The molecular and cellular biology of platelet-derived growth factor. Acta Endocrinologica (Copenhagen) 123, 131–142.Google ScholarPubMed
Williams, L.T. (1989). Signal transduction by the platelet-derived growth factor receptor. Science 243, 1564–1570.CrossRefGoogle ScholarPubMed
Yarden, Y., Escobedo, J.A., Kuang, W.-J., Yang-Feng, T.L., Daniel, T.O., Tremble, P.M., Chen, E.Y., Ando, M.E., Harkins, R.N., Francke, U., Fried, V.A., Ullrich, A. & Williams, L.T. (1986). Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323, 226–232.CrossRefGoogle ScholarPubMed
Yeh, H.-J., Ruit, K.G., Wang, Y.-X., Parks, W.C., Snider, W.D. & Deuel, T.F. (1991). PDGF A-chain gene is expressed by mammalian neurons during development and in maturity. Cell 64, 209–216.CrossRefGoogle ScholarPubMed
Yeh, H.-J., Silos-Santiago, I., Wang, Y.-X., George, R.J., Snider, W.D. & Deuel, T.F. (1993). Developmental expression of the platelet-derived growth factor α-receptor gene in mammalian central nervous system. Proceedings of the National Academy of Sciences of the U.S.A. 90, 1952–1956.CrossRefGoogle ScholarPubMed
Zippel, R., Morello, L., Brambilla, R., Comoglio, P.M., Alber-ghina, L. & Sturani, E. (1989). Inhibition of phosphotyrosine phosphatases reveals candidate substrates of the PDGF receptor kinase. European Journal of Cell Biology 50, 428–434.Google ScholarPubMed