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Photoreceptor replacement therapy: Challenges presented by the diseased recipient retinal environment

Published online by Cambridge University Press:  19 June 2014

RACHAEL A. PEARSON ,
CLAIRE HIPPERT ,
ANNA B. GRACA  and
AMANDA C. BARBER
RACHAEL A. PEARSON*
Affiliation:
Department of Genetics, University College London Institute of Ophthalmology, London, UK
CLAIRE HIPPERT
Affiliation:
Department of Genetics, University College London Institute of Ophthalmology, London, UK
ANNA B. GRACA
Affiliation:
Department of Genetics, University College London Institute of Ophthalmology, London, UK
AMANDA C. BARBER
Affiliation:
John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK
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Abstract

Vision loss caused by the death of photoreceptors is the leading cause of irreversible blindness in the developed world. Rapid advances in stem cell biology and techniques in cell transplantation have made photoreceptor replacement by transplantation a very plausible therapeutic strategy. These advances include the demonstration of restoration of vision following photoreceptor transplantation and the generation of transplantable populations of donor cells from stem cells. In this review, we present a brief overview of the recent progress in photoreceptor transplantation. We then consider in more detail some of the challenges presented by the degenerating retinal environment that must play host to these transplanted cells, how these may influence transplanted photoreceptor cell integration and survival, and some of the progress in developing strategies to circumnavigate these issues.

Keywords

TransplantationPhotoreceptorDegenerationGliosisStem cells
Type
Review Articles
Information
Visual Neuroscience , Volume 31 , Issue 4-5: Strategies for Restoring Sight in Retinal Dystrophies , September 2014 , pp. 333 - 344
Copyright
Copyright © Cambridge University Press 2014 

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