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p-Chloroamphetamine treatment modifies evoked responses to sinusoidal gratings in the pigeon optic tectum

Published online by Cambridge University Press:  02 June 2009

R. Alesci ,
V. Porciatti ,
L. Sebastiani  and
P. Bagnoli
R. Alesci
Affiliation:
Department of Physiology and Biochemistry, Universtiy of Pisa, Italy
V. Porciatti
Affiliation:
Institute of Neurophysiology, C.N.R., Pisa, Italy
L. Sebastiani
Affiliation:
Department of Physiology and Biochemistry, Universtiy of Pisa, Italy
P. Bagnoli
Affiliation:
Department of Physiology and Biochemistry, Universtiy of Pisa, Italy
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Abstract

This study was performed in order to establish whether selective depletion of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the pigeon optic tectum (TeO) induced by p-chloroamphetamine (p-CA) modified tectal evoked potentials (TEPs). TEPs in response to sinusoidal gratings of different contrast, spatial and temporal frequency were recorded in control pigeons and in pigeons intraperitoneally injected with p-CA (10 mg/kg; two administrations in consecutive days). TEPs of p-CA treated pigeons, as compared to those of control pigeons, were reduced in amplitude as a function of contrast, spatial and temporal frequency. In addition, TEPs of p-CA treated pigeons differed from those recorded in controls in their transfer characteristics of contrast and spatial frequency. In particular, TEPs of p-CA treated pigeons did not saturate at moderate contrast, unlike those of controls. Furthermore, the TEP spatial tuning in p-CA treated pigeons is broader than that in controls; it thus suggests a reduction of spatial-frequency selectivity. These findings indicate that a selective neurotoxin for serotonergic systems, such as p-CA, can serve as a useful denervation tool for the study of the serotonergic function in the pigeon TeO. In addition, selective changes of TEP properties suggest the possibility that serotonergic afferents play a modulatory role on the receptive-field characteristics of tectal neurons.

Keywords

Pattern evoked potentialsOptic tectump-chloroamphetamineSerotonin depletionPigeon
Type
Research Articles
Information
Visual Neuroscience , Volume 2 , Issue 2 , February 1989 , pp. 147 - 152
Copyright
Copyright © Cambridge University Press 1989

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