Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-22T16:04:04.708Z Has data issue: false hasContentIssue false
  • English
  • Français

Neuromodulation of pigment movement in the RPE of normal and 6-OHDA-lesioned goldfish retinas

Published online by Cambridge University Press:  02 June 2009

Alexander K. Ball ,
William H. Baldridge  and
Timothy C. Fernback
Alexander K. Ball
Affiliation:
Division of Anatomy and Experimental Morphology, McMaster University, Hamilton, Ontario, Canada
William H. Baldridge
Affiliation:
Division of Anatomy and Experimental Morphology, McMaster University, Hamilton, Ontario, Canada
Timothy C. Fernback
Affiliation:
Division of Anatomy and Experimental Morphology, McMaster University, Hamilton, Ontario, Canada
Get access Rights & Permissions [Opens in a new window]

Abstract

The role of dopamine as the endogenous signal-initiating light-dependent changes in the distribution of pigment granules in goldfish retinal pigment epithelium was investigated. In normal retinas, light adaptation resulted in the dispersion of pigment granules. This effect of light was mimicked by the intraocular injection of dopamine or serotonin, which is thought to increase endogenous dopamine release, into dark-adapted eyes. The effect of light, dopamine, or serotonin on dark-adapted retinas was blocked by the dopamine receptor antagonists haloperidol and sulpiride. However, lesioning the endogenous source of retinal dopamine, by prior intraocular injection of 6-hydroxydopamine (6-OHDA), did not block the dispersion of pigment granules in light-adapted retinas. No significant differences in pigment dispersion were noted between unlesioned and lesioned light- or dark-adapted retinas. However, the effect of light on pigment dispersion was no longer blocked by haloperidol or sulpiride in 6-OHDA lesioned animals. Dopamine and serotonin mimicked the effect of light when injected into lesioned dark-adapted eyes, but their effects were also not blocked by haloperidol or sulpiride. These results suggest that dopamine, acting on D2 receptors, is sufficient to induce pigment migration in unlesioned animals. In 6-OHDA-lesioned animals, however, pigment migration is mediated by a receptor mechanism other than D2.

Keywords

Pigment movementPigment epithelium6-HydroxydopamineRetinaGoldfish
Type
Articles
Information
Visual Neuroscience , Volume 10 , Issue 3 , May 1993 , pp. 529 - 540
Copyright
Copyright © Cambridge University Press 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adams, J.C. (1981). Heavy metal intensification of DAB-based HRP reaction product. Journal of Histochemistry and Cytochemistry 29, 775.CrossRefGoogle ScholarPubMed
Ali, M.A. (1975). Retinomotor responses. In Vision in Fishes, ed. Ail, M.A., pp. 369–396. New York: Plenum Press.CrossRefGoogle Scholar
Baldridge, W.H. & Ball, A.K. (1991). Background illumination reduces horizontal cell receptive-field size in both normal and 6-hydroxydopamine-lesioned goldfish retinas. Visual Neuroscience 7, 441–450.CrossRefGoogle ScholarPubMed
Baldridge, W.H., Ball, A.K. & Miller, R.G. (1987). Dopaminergic regulation of horizontal cell gap-junction particle density in goldfish retina. Journal of Comparative Neurology 265, 428–437.CrossRefGoogle ScholarPubMed
Baldridge, W.H., Ball, A.K. & Miller, R.G. (1989). Gap-junction particle density of horizontal cells in goldfish retinas lesioned with 6-OHDA. Journal of Comparative Neurology 287, 238–246.CrossRefGoogle ScholarPubMed
Ball, A.K. & Baldridge, W.H. (1991). Dopamine-β-hydroxylase immunoreactive amacrine cells in goldfish retina. Investigative Ophthalmology and Visual Science (Suppl.) 32, 1259.Google Scholar
Ball, A.K. & Tutton, D.A. (1990). Contacts between ’SI’ amacrine cells and ‘II’ interplexiform cells in the goldfish retina. Investigative Ophthalmology and Visual Science (Suppl.) 31, 332.Google Scholar
Burnside, B. & Ackland, N. (1984). Effects of circadian rhythm and cAMP on retinomotor movements in the green sunfish Lepomis cyanellus. Investigative Ophthalmology and Visual Science 25, 539–545.Google ScholarPubMed
Dearry, A. & Burnside, B. (1986 a). Dopaminergic regulation of cone retinomotor movement in isolated Teleost Retinas, I. Induction of cone contraction is mediated by D2-receptors. Journal of Neuro-chemistry 46, 1006–1021.CrossRefGoogle ScholarPubMed
Dearry, A. & Burnside, B. (1986 b). Dopaminergic regulation of cone retinomotor movement in isolated teleost retinas, II. Modulation by γ-aminobutyric acid and serotonin. Journal of Neurochemistry 46, 1022–1031.CrossRefGoogle ScholarPubMed
Dearry, A. & Burnside, B. (1988). Stimulation of distinct D2 dopaminergic and α2-adrenergic receptors induces light-adaptive pigment dispersion in teleost retinal pigments epithelium. Journal of Neurochemistry 51, 1516–1523.CrossRefGoogle Scholar
Dearry, A. & Burnside, B. (1989). Light-induced dopamine release from teleost retinas acts as a light-adaptive signal to the retinal pigment epithelium. Journal of Neurochemistry 53, 870–878.CrossRefGoogle Scholar
Douglas, R.H. & Wagner, H.-J. (1982). Endogenous patterns of photomechanical movements in teleosts and their relation to activity rhythms. Cell and Tissue Research 226, 133–144.CrossRefGoogle ScholarPubMed
Douglas, R.H., Wagner, H.-J., Zaunreiter, M., Behrens, U.D. & Djamgoz, M.B.A. (1992). The effect of dopamine depletion on lightevoked and circadian retinomotor movements in the teleost retina. Visual Neuroscience 9, 335–344.CrossRefGoogle ScholarPubMed
Dowling, J.E. & Ehinger, B. (1978). The interplexiform cell system. I. Synapses of the dopaminergic neuron of the goldfish retina. Proceedings of the Royal Society B (London) 201, 7–26.Google Scholar
Dubocovich, M.L., Lucas, R.C. & Takahashi, J.S. (1985). Light-dependent regulation of dopamine receptors in mammalian retina. Brain Research 335, 321–325.CrossRefGoogle ScholarPubMed
Ishita, S., Negishi, K., Teranishi, T., Shimada, Y. & Kato, S. (1988). GABAergic inhibition on dopamine cells of the fish retina: A (3H)-dopamine release study with isolated cell fractions. Journal of Neurochemistry 50, 1–6.CrossRefGoogle Scholar
Jaffe, E.H., Urbina, M., Ayala, C., Drujan, Y. & Drujan, B.D. (1987). Dopamine and noradrenaline content in fish retina: Modulation by serotonin. Journal of Neuroscience Research 18, 345–351.CrossRefGoogle ScholarPubMed
Jaffe, E.H., Urbina, M. & Drujan, B.D. (1991). Possible neurotransmitter role of noradrenaline in the teleost retina. Journal of Neuroscience Research 29, 190–195.CrossRefGoogle ScholarPubMed
Kato, S., Teranishi, T., Kuo, C.H. & Negishi, K. (1982). 5-Hydroxytryptamine stimulates (3H)-dopamine release from the fish retina. Journal of Neurochemistry 39, 493–498.CrossRefGoogle Scholar
Kirsch, M. & Wagner, H.-J. (1989). Release pattern of endogenous dopamine in teleost retinae during light adaptation and pharmacological stimulation. Vision Research 29, 147–154.CrossRefGoogle ScholarPubMed
Kohler, K., Kolbinger, W., Kurz-Isler, G. & Weiler, R. (1990). Endogenous dopamine and cyclic events in the fish retina, II. Correlation of retinomotor movement, spinule formation, and density of gap junctions with dopamine activity during light/dark cycles. Visual Neuroscience 5, 417–428.CrossRefGoogle ScholarPubMed
Kolbinger, W., Kohler, K., Oetting, H. & Weiler, R. (1990). Endogenous dopamine and cyclic events in the fish retina, I: HPLC assay of total content, release, and metabolic turnover during different light/dark cycles. Visual Neuroscience 5, 143–149.CrossRefGoogle ScholarPubMed
Mangel, S.C. & Dowling, J.E. (1985). Responsiveness and receptivefield size of carp horizontal cells are reduced by prolonged darkness and dopamine. Science 229, 1107–1109.CrossRefGoogle Scholar
Marc, R.E., Lui, W.S., Scholz, K. & Muller, J.F. (1988). Serotonergic and serotonin-accumulating neurons in the goldfish retina. Journal of Neuroscience 8, 3427–3450.CrossRefGoogle ScholarPubMed
McCormack, C.A. & Burnside, B. (1991 a). Effects of circadian phase on cone retinomotor movements in the Midas cichlid. Experimental Eye Research 52, 431–438.CrossRefGoogle ScholarPubMed
McCormack, C.A. & Burnside, B. (1991 b). Dopamine modulates circadian cone myoid movements in the teleost retina. Investigative Ophthalmology and Visual Science (Suppl.) 32, 847.Google Scholar
O’Connor, P., Dorison, S.J., Waiting, K.J. & Dowling, J.E. (1986). Factors affecting release of 3H-dopamine from perfused carp retina. Journal of Neuroscience 6, 1857–1865.CrossRefGoogle ScholarPubMed
Pierce, M.E. & Besharse, J.C. (1985). Circadian regulation of retinomotor Movements, I. Interaction of melatonin and dopamine in the control of cone length. Journal of General Physiology 86, 671–689.CrossRefGoogle ScholarPubMed
Porceddu, M.L., DeMontis, G., Mele, S., Ongini, E. & Biggio, G. (1987). D1; dopamine-receptors in the rat retina: Effect of dark-adaptation and chronic blockade by SCH-23390. Brain Research 424, 264–271.CrossRefGoogle ScholarPubMed
Schutte, M. & Witkovsky, P. (1991). Dopaminergic interplexiform cells and centrifugal fibres in the Xenopus retina. Journal of Neurocytology 20, 195–207.CrossRefGoogle ScholarPubMed
Seeman, P. (1980). Brain dopamine receptors. Pharmacological Review 32, 229–313.Google ScholarPubMed
Shigematsu, Y. & Yamada, M. (1988). Effects of dopamine of spatial properties of horizontal cell responses in carp retina. Neuroscience Research (Suppl.) 8, s69–S80.Google ScholarPubMed
Tornqvist, K., Yang, Y.-L. & Dowling, J.E. (1988). Modulation of cone horizontal cell activity in the teleost retina, III. Effects of prolonged darkness and dopamine on electrical coupling between horizontal cells. Journal of Neuroscience 8, 2279–2288.CrossRefGoogle ScholarPubMed
Umino, O., Lee, Y. & Dowling, J.E. (1991). Effects of light stimuli on the release of dopamine from interplexiform cells in the white perch retina. Visual Neuroscience 7, 451–458.CrossRefGoogle ScholarPubMed
Wagner, H.-J. & Wulle, I. (1990). Dopaminergic interplexiform cells contact the photoreceptor terminals in catfish retina. Cell and Tissue Research 261, 359–365.CrossRefGoogle Scholar
Wagner, H.-J., Zaunreiter, M., Behrens, U.D. & Douglas, R.H. (1991). Control of spinule formation in teleost horizontal cells: Endogenous circadian factors and dopamine effects. Investigative Ophthalmology and Visual Science 32, 1261.Google Scholar
Witkovsky, P., Stone, S. & Besharse, J.C. (1988). The effects of dopamine and related ligands on photoreceptor to horizontal cell transfer in the Xenopus retina. Biomedical Research (Suppl.) 9, 93–107.Google Scholar