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Nerve growth factor (NGF) uptake and transport following injection in the developing rat visual cortex

Published online by Cambridge University Press:  02 June 2009

Luciano Domenici ,
Gigliola Fontanesi ,
Antonio Cattaneo ,
Paola Bagnoli  and
Lamberto Maffei
Luciano Domenici
Affiliation:
Institute of Neurophysiology, Italian Research Council, Pisa, Italy
Gigliola Fontanesi
Affiliation:
Department of Physiology and Biochemistry, University of Pisa, Italy
Antonio Cattaneo
Affiliation:
International School of Advanced Studies, University of Trieste, Italy
Paola Bagnoli
Affiliation:
Department of Physiology and Biochemistry, University of Pisa, Italy
Lamberto Maffei
Affiliation:
Institute of Neurophysiology, Italian Research Council, Pisa, Italy
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Abstract

Recent investigations have shown that cortical nerve growth factor (NGF) infusions during the critical period inhibit ocular-dominance plasticity in the binocular portion of the rat visual cortex. The mechanisms underlying the effects of NGF on visual cortical plasticity are still unclear. To investigate whether during normal development intracortical and/or extracortical cells possess uptake/transport mechanisms for the neurotrophin, we injected 125I-NGF into the occipital cortex of rats at different postnatal ages. Within the cortex, only a few labelled cells were observed. These cells were confined to the vicinity of the injection site and their number depended on the animal's age at the time of injection. Labelled cells were absent at postnatal day (PD) 10 but could be detected between PD 14 and PD 18. They then decreased in number over the following period and were not detected in adult animals. Outside the cortex, neurons of the lateral geniculate nucleus (LGN) were not observed to take up and retrogradely transport NGF at any age after birth. In contrast, retrogradely labelled neurons were found in the basal forebrain. Labelled cells were first observed here at PD 14 and then increased in number until reaching the adult pattern. Our results show that intrinsic and extrinsic neurons are labelled following intracortical injections of iodinated NGF. In both neuronal populations, the uptake and transport of NGF is present over a period corresponding to the critical period for visual cortical plasticity. These findings suggest that NGF may play a role, both intra and extracortically, in plasticity phenomena.

Keywords

NeurotrophinVisual cortexBasal forebrainLateral geniculate nucleusDevelopmentPlasticity
Type
Research Articles
Information
Visual Neuroscience , Volume 11 , Issue 6 , November 1994 , pp. 1093 - 1102
Copyright
Copyright © Cambridge University Press 1994

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