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NADPH-diaphorase neurones of human retinae have a uniform topographical distribution

Published online by Cambridge University Press:  02 June 2009

Jan M. Provis  and
John Mitrofanis
Jan M. Provis
Affiliation:
Department of Anatomy, University of Sydney, Australia Save Sight and Eye Health Institute, University of Sydney, Australia
John Mitrofanis
Affiliation:
Department of Anatomy, University of Sydney, Australia
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Abstract

We have examined the morphology and distribution of neurones that contain nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase in human retinae. NADPH-diaphorase reactivity was observed in three different classes of amacrine cells (ND1, ND2, ND3 cells) and in the cone photoreceptors. ND1 cells had relatively large somata (mean, 12.3 ¼m) located in the inner nuclear layer (INL) and in the ganglion cell layer (GCL). Their dendrites were often strongly labeled and spread into either the middle or outer strata of the inner plexiform layer (IPL). The somata of ND2 cells were medium-sized (mean, 8.2 ¼m) and located in the INL and in the GCL; their dendrites were usually beaded and often spread in either the middle or outer strata of the IPL. ND3 cells had small, round somata (mean, 5.2 ¼m) located in either the INL or GCL, and were without labeled processes. The total number of NADPH-diaphorase cells (all classes) was estimated at 118,000, with a mean density of about 100/mm2. The most striking fea ture of NADPH-diaphorase cells in humans was that their distribution was relatively uniform across the retina, with no evidence of a peak in density at the foveal rim.

Keywords

Amacrine cellsConesFovea centralisRetinal topography
Type
Short Communication
Information
Visual Neuroscience , Volume 4 , Issue 6 , June 1990 , pp. 619 - 623
Copyright
Copyright © Cambridge University Press 1990

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