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Foveal dark adaptation, photopigment regeneration, and aging

Published online by Cambridge University Press:  02 June 2009

D. Caroline Coile
Affiliation:
Program in Psychobiology and Neuroscience, The Florida State University, Tallahassee
Howard D. Baker
Affiliation:
Program in Psychobiology and Neuroscience, The Florida State University, Tallahassee

Abstract

Foveal dark adaptation in 58 subjects and photopigment regeneration in 60 subjects from 10–78 years of age exhibit parallel slowing of recovery rate with increasing age, with significant correlation of the two functions among individuals. The data are suggestive of an initial slight decline in rate before age 50, followed by a greater decline occuring at different ages in different ages in different individuals. Longitudinal data for one subject from age 40–65 show an increase in pigment regeneration time constant consistent with this idea. Foveal sensitivity and photopigment density both decrease with increasing age and are significantly correlated among individuals, although sensitivity declines more with age than does photopigment density. In contrast to earlier proposals based upon the Rushton-Dowling equation, we found no universal constant of proportionality to relate log relative threshold to photopigment within our population.

Type
Research Articles
Copyright
Copyright © Cambridge University Press 1992

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References

Baker, H.D. & Coile, D.C. (1987). Retinal densitometry with the natural pupil. Investigative Ophthalmology and Visual Science (Suppl.), 28, 219.Google Scholar
Baker, H.D., Henderson, R. & O'Keefe, L.O. (1989). An improved retinal densitometer: Design concepts and experimental applications. Visual Neuroscience 3, 7180.CrossRefGoogle ScholarPubMed
Baker, H.D. & Kuyk, T.K. (1980). In vivo densitometry of cone pigments after repeated complete bleaching. In The Effects of Constant Light on Visual Processes, ed. Williams, T.P. & Baker, B.N., pp. 347–353. New York: Plenum Press.Google Scholar
Baker, H.D., Watson, A.J. & Coile, D.C. (1991). Experimental stray light in retinal densitometry. Visual Neuroscience 6, 615620.CrossRefGoogle ScholarPubMed
Balazsi, A.G., Rootman, J., Drance, S.M., Schulzer, M. & Douglas, G.R. (1984). The effect of age on the nerve fiber population of the human optic nerve. American Journal of Ophthalmology 97, 760766.CrossRefGoogle ScholarPubMed
Birren, J.E., Bick, M.W. & Fox, C. (1948). Age changes in the light threshold of the dark adapted eye. Journal of Gerontology 3, 267271.CrossRefGoogle ScholarPubMed
Birren, J.E., Casperson, R.C. & Botwinick, J. (1950). Age changes in rate and level of visual dark adaptation. Journal of Gerontology 5, 216221.Google Scholar
Birren, J.E. & Shock, N.W. (1950). Age changes in rate and level of visual dark adaptation. Journal of Applied Physiology 2, 407411.Google Scholar
Carter-Dawson, L., Lavail, M. & Sidman, R. (1978). Differential effect of the rd mutation on rods and cones in the mouse retina. Investigative Ophthalmology and Visual Science 17, 489494.Google ScholarPubMed
Chu, F.C., Reingold, D.B., Cogan, D.G. & Williams, A.C. (1979). The eye movement disorder of progressive supranuclear palsy. Ophthalmology 86, 422428.CrossRefGoogle ScholarPubMed
Cicerone, C.M. (1976). Cones survive rods in the light-damaged eye of the albino rat. Science 194, 11831185.CrossRefGoogle ScholarPubMed
Devaney, K.O. & Johnson, H.A. (1980). Neuron loss in the aging visual cortex of man. Journal of Gerontology 35, 836841.Google Scholar
Domey, R.G., Mcfarland, R.A. & Chadwick, E. (1960). Threshold and rate of dark adaptation as functions of age and time. Human Factors 2, 109119.Google Scholar
Dorey, C.K., Wu, G., Ebenstein, D., Garsd, A. & Weiter, J.J. (1989). Cell loss in the aging retina: Relationship to lipofuscin accumulation and macular degeneration. Investigative Ophthalmology and Visual Science 30, 16911699.Google ScholarPubMed
Dowling, J. (1960). The Chemistry Of Visual Adaptation In The Rat. Nature 188, 114118.Google Scholar
Eisner, A. (1987). Comparisons across age of selected visual functions. Documenta Ophthalmologica Proceedings Series 46, 99109.CrossRefGoogle Scholar
Eisner, A., Fleming, S.A., Klein, M.L. & Mauldin, W.M. (1987a). Sensitivities in healthy older eyes with good acuity: Cross-sectional norms. Investigative Ophthalmology and Visual Science 28, 18241831.Google Scholar
Eisner, A., Fleming, S.A., Klein, M.L. & Mauldin, W.M. (1987b). Sensitivities in older eyes with good acuity: Eyes whose fellow eye has exudative AMD. Investigative Ophthalmology and Visual Science 28, 18321837.Google Scholar
Elliott, D.B., Whitaker, D. & Thompson, P. (1989). Use of displacement threshold hyperacuity to isolate the neural component of senile vision loss. Applied Optics 28, 19141918.CrossRefGoogle ScholarPubMed
Feeney-Burns, L., Hilderbrand, E.S. & Eldridge, S. (1984). Aging Human RPE: Morphometric analysis of macular, equatorial, and peripheral cells. Investigative Ophthalmology and Visual Science 25, 195200.Google ScholarPubMed
Friedman, E. & T'so, M.O.M. (1968). The retinal pigment epithelium. II. Histological changes associated with age. Archives of Ophthalmology 79, 315320.CrossRefGoogle ScholarPubMed
Gartner, S. & Henkind, P. (1981). Aging and degeneration of the human macula. 1. Outer nuclear layer and photoreceptors. British Journal of Ophthalmology 65, 2328.CrossRefGoogle ScholarPubMed
Geisler, W.S. (1980). Comments on the testing of two prominent dark adaptation hypotheses. Vision Research 20, 807811.Google Scholar
Gunkel, R.D. & Gouras, P. (1963). Changes in scotopic visibility thresholds wth age. Archives of Ophthalmology 69, 49.CrossRefGoogle Scholar
Hollins, M. & Alpern, M. (1973). Dark adaptation and visual pigment regeneration in human cones. Journal of General Physiology 62, 430447.Google Scholar
Johnson, M.A. & Choy, D. (1987). On the definition of age-related norms for visual function testing. Applied Optics 26, 14491454.CrossRefGoogle ScholarPubMed
Kadlecova, V., Peleska, M. & Vasko, A. (1958). Dependence on age of the diameter of the pupil in the dark. Nature 182, 15201521.CrossRefGoogle ScholarPubMed
Keunen, J.E.E., Van Norren, D. & Van Meel, G.J. (1987). Density Of Foveal Cone Pigments At Older Age. Investigative Ophthalmology and Visual Science 28, 985991.Google Scholar
Kilbride, D.E., Hutman, L.P., Fishman, M. & Read, J.S. (1986). Foveal cone pigment density difference in the aging human eye. Vision Research 26, 321325.CrossRefGoogle ScholarPubMed
King-Smith, P.E. (1973). The optical density of erythrolabe determined by a new method. Journal of Physiology (London) 230, 551560.Google Scholar
Kosnik, W., Fikre, J. & Sekuler, R. (1986). Visual fixation stability in older adults. Investigative Ophthalmology and Visual Science 27, 17201725.Google Scholar
Marshall, J., Grindle, J., Ansell, P.L. & Borwein, B. (1979). Convolution in human rods: an aging process. British Journal of Ophthalmology 63, 181187.Google Scholar
Mcfarland, R.A., Domey, R.G., Warren, A.B. & Ward, D.C. (1960). Dark-adaptation as a function of age: I. A statistical analysis. Journal of Gerontology 15, 149154.CrossRefGoogle Scholar
Mote, F.A. & Riopelle, A.J. (1951). The effect of varying the intensity and the duration of preexposure upon foveal dark adaptation in the human eye. Journal of General Physiology 34, 657674.CrossRefGoogle ScholarPubMed
Noell, W.K. (1965). Aspects of experimental and hereditary retinal degeneration. In Biochemistry of the Retina, ed. Graymore, C.N., pp. 5172. London: Academic Press.Google Scholar
Pflibsen, K.P., Pomerantzoff, O. & Ross, R.N. (1988). Retinal illumination using a wide-angle model of the eye. Journal of the Optical Society of America 5, 146150.Google Scholar
Repka, M.X. & Quigley, H.A. (1989). The effect of age on normal human optic nerves. Investigative Ophthalmology and Visual Science (Suppl.) 30, 355.Google Scholar
Ripps, H., Mehaffey, L. & Siegal, I.M. (1981). Rhodopsin kinetics in the cat retina. Journal of General Physiology 77, 317334.Google Scholar
Robertson, G.W. & Yudkin, J. (1944). Effect of age upon dark adaptation. Journal of Physiology 103, 18.Google Scholar
Rushton, W.A.H. (1961a). Dark adaptation and the regeneration of rhodopsin. Journal of Physiology (London) 156, 166178.CrossRefGoogle ScholarPubMed
Rushton, W.A.H. (1961b). Rhodopsin measurements and dark adaptation in a subject deficient in cone vision. Journal of Physiology (London) 156, 193201.Google Scholar
Rushton, W.A.H., &Fulton, A.B. & Baker, H.D. (1969). Dark adaptation and the rate of pigment regeneration. Vision Research 9, 14731478.Google Scholar
Rushton, W.A.H. & Henry, G.B. (1968). Bleaching and regeneration of cone pigments in man. Vision Research 8, 617631.CrossRefGoogle ScholarPubMed
Rushton, W.A.H. & Powell, D.S. (1972). The rhodopsin content and the visual threshold of human rods. Vision Research 12, 10731081.CrossRefGoogle ScholarPubMed
Said, F.S. & Sawires, W.S. (1972). Age dependence of changes in pupil diameter in the dark. Optica Acta 19, 359361.Google Scholar
Said, F.S. & Weale, R.A. (1959). The variation with age of the spectral transmissivity of the living human crystalline lens. Gerontologia 3, 213231.Google Scholar
Sarks, S.H. (1976). Ageing and degeneration in the macular region: a clinico-pathological study. British Journal of Ophthalmology 60, 324341.Google Scholar
Severin, S.L., Tour, R.L. & Kershaw, R.H. (1967a). Macular function and the photostress test 1. Archives of Ophthalmology 77, 27.Google Scholar
Severin, S.L., Tour, R.L. & Kershaw, R.H. (1967b). Macular function and the photostress test 2. Archives of Ophthalmology 77, 163167.CrossRefGoogle ScholarPubMed
Sloan, L.L. (1940). Instruments and techniques for the clinical testing of light sense. IV. Size of pupil as a variable factor in the determination of the light minimum. Archives of Ophthalmology 24, 258275.Google Scholar
Steven, D.M. (1946). Relation between dark-adaptation and age. Nature 157, 376377.Google Scholar
Storandt, M. (1982). Concepts and methodological issues in the study of aging. In Aging and Human Visual Function, ed. Sekuler, R., Kline, D. & Dismukes, K., pp. 269–278. New York: Alan R. Liss, Inc.Google Scholar
Szamier, R.B., Berson, E.L., Klein, L. & Meyers, S. (1979). Sexlinked retinitis pigmentosa: Ultrastructure of photoreceptors and pigment epithelium. Investigative Ophthalmology and Visual Science 18, 145160.Google Scholar
T'so, M.O.M. & Friedman, E. (1968). The retinal pigment epithelium: III. Growth and development. Archives of Ophthalmology 80, 214216.Google Scholar
Van Blokland, G.J. & Van Norren, D. (1986). Intensity and polarization of light scattered at small angles from the human fovea. Vision Research 26, 485494.Google Scholar
Van Norren, D. & Van Der Kraats, J. (1981). A continuously recording retinal densitometer. Vision Research 21, 897905.Google Scholar
Van Norren, D. & Van Meel, G.J. (1985). Density of human cone photopigments as a function of age. Investigative Ophthalmology and Visual Science 26, 10141017.Google ScholarPubMed
Weale, R.A. (1982). Senile ocular changes, cell death, and vision. In Aging and Human Visual Function, ed. Sekuler, R., Kline, D. & Dismukes, K., pp 161171. New York: Alan R. Liss, Inc.Google Scholar
Weale, R.A. (1971). On the birefringence of rods and cones. Pflugers Archiv 329, 244257.Google Scholar
Weale, R.A. (1975). Senile changes in visual acuity. Transactions of the Ophthalmological Society of the U.K. 95, 3638.Google Scholar
Weale, R.A. (1978). The eye and aging. Interdisciplinary Topics in Gerontology 13, 113.Google Scholar
Woodhouse, J.M. & Campbell, F.W. (1975). The role of the pupil light reflex in aiding adaptation to the dark. Vision Research 15, 649653.CrossRefGoogle ScholarPubMed
Yuodelis, C. & Hendrickson, A. (1986). A qualitative and quantitative analysis of the human fovea during development. Vision Research 26, 847855.Google Scholar
Zwas, F. (1988). Light absorption measurements in the human lens. Investigative Ophthalmology and Visual Science (Suppl.), 29, 446.Google Scholar