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The effect of contrast on the visual response of lagged and nonlagged cells in the cat lateral geniculate nucleus

Published online by Cambridge University Press:  02 June 2009

E. Hartveit  and
P. Heggelund
E. Hartveit
Affiliation:
Department of Neurophysiology, University of Oslo, N-0317 Oslo, Norway
P. Heggelund
Affiliation:
Department of Neurophysiology, University of Oslo, N-0317 Oslo, Norway
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Abstract

The response vs. contrast characteristics of different cell classes in the dorsal lateral geniculate nucleus (LGN) were compared. The luminance of a stationary flashing light spot was varied stepwise while the background luminance was constant. Lagged X cells had lower slope of the response vs. contrast curve (contrast gain), and they reached the midpoint of the response range over which the cells' response varied (dynamic response range) at higher contrasts than nonlagged X cells. These results indicated that nonlagged cells are well suited for detection of small contrasts, whereas lagged cells may discriminate between contrasts over a larger range. The contrast gain and the contrast corresponding to the midpoint of the dynamic response range were similar for X and Y cells. The latency to onset and to half-rise of the visual response decreased with increasing contrast, most pronounced for lagged cells. Even at the highest contrasts, the latency of lagged cells remained longer than for nonlagged cells. For many lagged cells, the latency to half-fall decreased with increasing contrast. It is shown that the differences in the response vs. contrast characteristics between lagged and nonlagged X cells in the cat are similar to the differences between the parvocellular and magnocellular neurones in the monkey.

Keywords

Contrast gainLagged cellsLateral geniculate nucleusNonlagged cellsSingle unit
Type
Research Articles
Information
Visual Neuroscience , Volume 9 , Issue 5 , November 1992 , pp. 515 - 525
Copyright
Copyright © Cambridge University Press 1992

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References

Bekkers, J.M. & Stevens, C.F. (1990). Computational implications of NMDA receptor channels. Cold Spring Harbor Symposia on Quantitative Biology 55, 131–135.CrossRefGoogle ScholarPubMed
Blakemore, C. & Vital-Durand, F. (1986). Organization and postnatal development of the monkey's lateral geniculate nucleus. Journal of Physiology 380, 453–491.Google Scholar
Bolz, J., Rosner, G. & Wassle, H. (1982). Response latency of brisksustained (X) and brisk-transient (Y) cells in the cat retina. Journal of Physiology 328, 171–190.Google Scholar
Brearley, J.C., Kellagher, R.E.B. & Hall, L.W. (1988). Propofol anesthesia in cats. Journal of Small Animal Practice 29, 315–322.Google Scholar
Cleland, B.G., Dubin, M.W. & Levick, W.R. (1971). Sustained and transient neurones in the cat's retina and lateral geniculate nucleus. Journal of Physiology 217, 473–496.CrossRefGoogle ScholarPubMed
Cleland, B.G., Harding, T.H. & Tulunay-Keesey, U. (1979). Visual resolution and receptive field size: Examination of two kinds of cat retinal ganglion cells. Science 205, 1015–1017.Google Scholar
Derrington, A.M., Krauskopf, J. & Lennie, P. (1984). Chromatic mechanisms in lateral geniculate nucleus of macaque. Journal of Physiology 357, 241–265.CrossRefGoogle ScholarPubMed
Derrington, A.M. & Lennie, P. (1984). Spatial and temporal contrast sensitivities of neurones in lateral geniculate nucleus of macaque. Journal of Physiology 357, 219–240.CrossRefGoogle ScholarPubMed
Dreher, B., Fukada, Y. & Rodieck, R.W. (1976). Identification, classification, and anatomical segregation of cells with X-like and Y-like properties in the lateral geniculate nucleus of Old-World primates. Journal of Physiology 258, 433–452.Google Scholar
Fox, K., Sato, H. & Daw, N. (1990). The effect of varying stimulus intensity on NMDA-receptor activity in cat visual cortex. Journal of Neurophysiology 64, 1413–1428.Google Scholar
Francesconi, W., Müller, C.M. & Singer, W. (1988). Cholinergic mechanisms in the reticular control of transmission in the cat lateral geniculate nucleus. Journal of Neurophysiology 59, 1690–1718.CrossRefGoogle ScholarPubMed
Galleti, C., Maioli, M.G., Squatrito, S. & Sanseverino, E. Riva (1979). Single unit responses to visual stimuli in cat cortical areas 17 and 18.1. Responses to stationary stimuli of variable intensity. Archives Italiennes de Biologie 117, 208–230.Google Scholar
Gouras, P. (1968). Identification of cone mechanisms in monkey ganglion cells. Journal of Physiology 199, 533–547.Google Scholar
Hartveit, E. & Heggelund, P. (1990). Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus. II. Non-lagged cells. Journal of Neurophysiology 63, 1361–1372.Google Scholar
Hartveit, E. & Heggelund, P. (1991). The effect of brainstem peribrachial stimulation on the contrast-response properties of cells in the cat lateral geniculate nucleus. Society for Neuroscience Abstracts 17, 710.Google Scholar
Heggelund, P. (1981). Receptive field organization of simple cells in cat striate cortex. Experimental Brain Research 42, 89–98.Google Scholar
Heggelund, P. & Hartveit, E. (1990). Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus. I. Lagged cells. Journal of Neurophysiology 63, 1347–1360.Google Scholar
Heggelund, P., Karlsen, H.E., Flugsrud, G. & Nordtug, T. (1989). Response to rates of luminance change of sustained and transient cells in the cat lateral geniculate nucleus and optic tract. Experimental Brain Research 74, 116–130.Google Scholar
Hubel, D.H. & Livingstone, M.S. (1990). Color and contrast sensitivity in the lateral geniculate body and primary visual cortex of the macaque monkey. Journal of Neuroscience 10, 2223–2237.Google Scholar
Hubel, D.H. & Wiesel, T.N. (1961). Integrative action in the cat's lateral geniculate body. Journal of Physiology 155, 385–398.Google Scholar
Humphrey, A.L. & Weller, R.E. (1988 a). Functionally distinct groups of X-cells in the lateral geniculate nucleus of the cat. Journal of Comparative Neurology 268, 429–447.CrossRefGoogle ScholarPubMed
Humphrey, A.L. & Weller, R.E. (1988 b). Structural correlates of functionally distinct groups of X-cells in the lateral geniculate nucleus of the cat. Journal of Comparative Neurology 268, 448–468.Google Scholar
Kaplan, E., Lee, B.B. & Shapley, R.M. (1990). New views of primate retinal function. In Progress in Retinal Research, Vol. 9, ed. Osborne, N.N. & Chader, G., pp. 273–336. Oxford: Pergamon Press.Google Scholar
Kaplan, E. & Shapley, R.M. (1982). X and Y cells in the lateral geniculate nucleus of macaque monkeys. Journal of Physiology 330, 125–143.CrossRefGoogle ScholarPubMed
Kaplan, E. & Shapley, R.M. (1986). The primate retina contains two types of ganglion cells, with high and low contrast sensitivity. Proceedings of the National Academy of Sciences of the U.S.A. 83, 2755–2757.CrossRefGoogle ScholarPubMed
Kwon, Y.H., Esguerra, M. & Sur, M. (1991). NMDA and nonNMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus. Journal of Neurophysiology 66, 414–428.CrossRefGoogle ScholarPubMed
Leventhal, A.G., Rodieck, R.W. & Preher, B. (1981). Retinal ganglion cell classes in the Old World monkey: Morphology and central projections. Science 213, 1139–1142.CrossRefGoogle ScholarPubMed
Levick, W.R. (1972). Another tungsten microelectrode. Medical Electronics and Biological Engineering 10, 510–515.Google Scholar
Mastronarde, D.N. (1987 a). Two classes of single-input X-cells in cat lateral geniculate nucleus. I. Receptive field properties and classification of cells. Journal of Neurophysiology 57, 357–380.Google Scholar
Mastronarde, D.N. (1987 b). Two classes of single-input X-cells in cat lateral geniculate nucleus. II. Retinal inputs and the generation of receptive field properties. Journal of Neurophysiology 57, 381–413.Google Scholar
Mastronarde, D.N. (1988). Branching of X- and Y-functional pathways in cat lateral geniculate nucleus. Society for Neuroscience Abstracts 14, 309.Google Scholar
Mastronarde, D.N., Humphrey, A.L. & Saul, A.B. (1991). Lagged Y cells in the cat lateral geniculate nucleus. Visual Neuroscience 7, 191–200.Google Scholar
Peichl, L. & Wassle, H. (1979). Size, scatter and coverage of ganglion cell receptive field centres in the cat retina. Journal of Physiology 291, 117–141.CrossRefGoogle ScholarPubMed
Purpura, K., Kaplan, E. & Shapley, R.M. (1988). Background light and the contrast gain of primate P and M retinal ganglion cells. Proceedings of the National Academy of Sciences of the U.S.A. 85, 4534–4537.Google Scholar
Rodieck, R.W., Pettigrew, J.D., Bishop, P.O. & Nikara, T. (1967). Residual eye movements in receptive field studies of paralyzed cats. Vision Research 7, 107–110.Google Scholar
Saul, A.B. & Humphrey, A.L. (1990). Spatial and temporal response properties of lagged and nonlagged cells in cat lateral geniculate nucleus. Journal of Neurophysiology 64, 206–224.Google Scholar
Schiller, P.H. & Malpeli, J.G. (1978). Functional specificity of lateral geniculate nucleus laminae of the rhesus monkey. Journal of Neurophysiology 41, 788–797.Google Scholar
Sestokas, A.K. & Lehmkuhle, S. (1986). Visual response latency of X- and Y-cells in the dorsal lateral geniculate nucleus of the cat. Vision Research 26, 1041–1054.Google Scholar
Shapley, R. & Enroth-Cugell, C. (1984). Visual adaptation and retinal gain controls. In Progress in Retinal Research, Vol. 3, ed. Osborne, N.N. & Chader, G., pp. 263–346. Oxford: Pergamon Press.Google Scholar
Shapley, R. & Perry, V.H. (1986). Cat and monkey retinal ganglion cells and their visual functional roles. Trends in Neurosciences 9, 229–235.CrossRefGoogle Scholar
Smith, V.C., Pokorny, J. & Lee, B.B. (1991). The contrast gain of P- and M-pathway cells expressed in cone contrast units. Investigative Ophthalmology and Visual Science (Suppl.) 32, 1034.Google Scholar
Steriade, M., Paré, D., Hu, B. & Deschenes, M. (1990). The Visual Thalamocortical System and Its Modulation by the Brain Stem Core. Berlin: Springer.CrossRefGoogle Scholar
Stone, J. (1983). Parallel Processing in the Visual System. New York: Plenum Press.Google Scholar
Szentágothai, J. (1973). Neuronal and synaptic architecture of the lateral geniculate nucleus. In Handbook of Sensory Physiology, Vol. VII/3B, ed. Jung, R., pp. 141–176. Berlin: Springer.Google Scholar
Wiesel, T.N. & Hubel, D.H. (1966). Spatial and chromatic interactions in the lateral geniculate body of the rhesus monkey. Journal of Neurophysiology 29, 1115–1156.Google Scholar
Winters, R.W. & Walters, J.W. (1970). Transient and steady state stimulus-response relations for cat retinal ganglion cells. Vision Research 10, 461–477.Google Scholar