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Direction-selective responses of units in the dorsal terminal nucleus of cat following intravitreal injections of bicuculline

Published online by Cambridge University Press:  02 June 2009

K.L. Grasse ,
M. Ariel  and
I.D. Smith
K.L. Grasse
Affiliation:
Departments of Psychology and Biology, York University North York, Ontario, Canada B3JIP3
M. Ariel
Affiliation:
Department of Behavioural Neuroscience, University of Pittsburgh, Pittsburgh
I.D. Smith
Affiliation:
Department of Behavioural Neuroscience, University of Pittsburgh, Pittsburgh
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Abstract

Extracellular recordings from single units in the dorsal terminal nucleus (DTN) of the cat accessory optic system (AOS) were before and after intravitreal injections of the GABA antagonist bicuculline methiodide (BMI). Direction-selective responses of DTN cells elicited through the contralateral, injected eye were aboloshed 7−12 h following the injection. For the concentrations tested, direction-selective responses through the contralateral (injected) eye did not recover within 26 h. Direction-selective responses through stimulation of the ipsilateral (uninjected) eye were also dramatically depressed for 1−9 h after contralateral eye injections. However, direction-selective responses through the ipsilateral eye eventually returned and were often more vigorous in the final stages. BMI injections into the ipsilateral eye failed to block direction-selective responses through the ipsilateral eye. The effects of intravitreal BMI on contralateral eye responses imply that DTN units receive input from direction-selective retinal ganglion cells. In addition, these results suggest that direction-selective input to the DTN from the visual cortex is independent of the retinal pathway. Using pharmacological methods described here, for the first time direction-selective responses of AOS units driven through the ipsilateral eye can be experimentally isolated.

Keywords

Dorsal terminal nucleusAccessory optic systemDirection selectivityBicuculline methiodideBinocular interactionsCat
Type
Research Articles
Information
Visual Neuroscience , Volume 4 , Issue 6 , June 1990 , pp. 605 - 617
Copyright
Copyright © Cambridge University Press 1990

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References

Adelson, E.H. & Bergen, J.R. (1985). Spatiotemporal energy models for the preception of motion. Journal of the Optical Society of America 2, 284–299.CrossRefGoogle Scholar
Ariel, M. (1989). Analysis of vertebrate eye movements following intravitreal drug injections, III: Spontaneous nystagmus is modulated by the GABAa receptor. Journal of Neurophysiology 62, 649–480.CrossRefGoogle ScholarPubMed
Ariel, M. & Adolph, A.R. (1985). Neurotransmitter inputs to directionally sensitive turtle retinal ganglion cells. Journal of Neurophysiology 54, 1123–1143.CrossRefGoogle ScholarPubMed
Ariel, M. & Daw, N.W. (1982). Pharmacological analysis of directionally sensitive rabbit retinal ganglion cells. Journal of Physiology 324, 161–185.CrossRefGoogle ScholarPubMed
Ariel, M., Robinson, F.R. & Knapp, A.G. (1988). Analysis of vertebrate eye movements following intravitreal drug injections, II: Spontaneous nystagmus induced by picrotoxin is mediated subcortically. Journal of Neurophysiology 60, 1022–1035.CrossRefGoogle ScholarPubMed
Barlow, H.B. & Levick, W.R. (1965). The Mechanism of directionally selective units in rabbit's retina. Journal of Physiology 178, 477–504.CrossRefGoogle ScholarPubMed
Berson, D.M. & Graybiel, A.M. (1980). Some cortical and subcortical fiber projections to the accessory optic nuclei in the cat. Neuroscience 5, 2203–2217.CrossRefGoogle Scholar
Caldwell, J.H., Daw, N.W. & Wyatt, H.J. (1978). Effects of picrotoxin and strychnine on rabbit retinal ganglion cells: lateral interactions for cells with more complex receptive fields. Journal of Physiology 276, 277–298.CrossRefGoogle ScholarPubMed
Collewijn, H. (1975). Direction-selective units in the rabbit's nucleus of the optic tract. Brain Research 100, 489–508.CrossRefGoogle ScholarPubMed
Curtis, D.R. & Johnston, G.R. (1974). Amino-acid transmitters in the mammalian C.N.S. Ergeb. Physiology 69, 97–188.Google Scholar
Farmer, S.G. & Rodieck, R.W. (1982). Ganglion cells of the cat acaessory optic system: morphology and retinal topography. Journal of Comparative Neurology 205, 190–198.CrossRefGoogle ScholarPubMed
Grasse, K., & Cynader, M. (1982). Electrophysiology of the medial terminal nucleus of the accessory optic system in the cat. Journal of Neurophysiology 48, 409–504.CrossRefGoogle ScholarPubMed
Grasse, K.L. & Cynader, M.S. (1984). Electrophysiology of lateral and dorsal terminal nuclei of the cat accessory optic system. Journal of Neurophysiology 51, 276–293.CrossRefGoogle ScholarPubMed
Grasse, K.L. & Cynader, M.S. (1986). Response properties of single units in the accessory optic system of the dark-reared cat. Developmental Brain Research 27, 199–210.CrossRefGoogle Scholar
Grasse, K.L. & Cynader, M.S. (1987). The accessory optic system of the monocularly deprived cat. Developmental Brain Reseatch 31, 229–241.CrossRefGoogle Scholar
Grasse, K.L. & Cynader, M.S. (1990). The accessory optic system in frontal-eyed animals. In Vision and Visual Dysfunction Vol. IV, The Neuronal Basis of Visual Function, ed. Levanthal, A., pp. 111–137. Basingstoke, England: The Macmillan Press (in press).Google Scholar
Grasse, K.L., Cynader, M.S. & Douglas, R.M. (1984). Alterations in response properties in the lateral and dorsal terminal nuclei of the cat accessory optic system following visual cortex lesions. Experimental Brain Research 55, 69–80.CrossRefGoogle ScholarPubMed
Grzywacz, N.M. & Koch, C. (1987). Functional properties of models for direction selectivity in the retina. Synapse 1, 417–434.CrossRefGoogle ScholarPubMed
Hayhow, W.R., (1959). An exprimental study of the accessory optic fiber system in the cat. Journal of Comparative Neurology 113, 281–313.CrossRefGoogle Scholar
Hchuerger, R.J., Rosenberg, A.F. & Ariel, M. (1990). Retinal direction-sensitive input to the accessory optic system: an in vitro approach with behavioral relevance. Brain Research (in Press).CrossRefGoogle Scholar
Hoffmann, K.P. & Schoppmann, A. (1975). Retinal input to direction-selective cells in the nucleus tractus opticus of the cat. Brain Research 99, 359–366.CrossRefGoogle ScholarPubMed
Marcotte, R.R. & Updyke, B.V. (1982). Cortical visual areas of the cat project differentially onto the nuclei of the accessory optic system. Brain Research 242, 205–217.CrossRefGoogle ScholarPubMed
Pong, S.F. & Graham, L.T. (1972). N-methyl bicuculline, a convulsant more potent than bicuculline. Brain Research 42, 486–498.CrossRefGoogle ScholarPubMed
Reichardt, W. (1961). Autocorrelation: a principle for the evaluation of sensory information by the central nervous system. In Sensory Communication ed. Rosenblith, W.A., pp. 303–317. Cambridge, Massachusetts: MIT Press.Google Scholar
Sillito, A.M. (1975). The contribution of inhibitory mechanisms to the receptive-field properties of neurons in the striate cortex of the cat. Journal of Physiology 250, 305–329.CrossRefGoogle Scholar
Sillito, A.M. (1977). Inhibitory processes underlyning the directional specificity of simple, complex, and hyper-complex cells in the cat's visual cortex. Journal of Physiology 271, 669–720.CrossRefGoogle Scholar
Simpson, J.I., Soodak, R.E. & Hess, R. (1979). The accessory optic system and its relation to the vestibulocerebellum. In Reflex Control of Posture and Movement, ed. Granit, R. & Pomoeiano, O., pp. 715–724. Amsterdam: Elsevier.CrossRefGoogle Scholar
van Santen, J.P.H. & Sperling, G. (1985). Elaborated Reichardt detectors. Journal Optical Society of America 2, 300–321.CrossRefGoogle ScholarPubMed