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Co-localization of glutamic acid decarboxylase and vesicular GABA transporter in cytochrome oxidase patches of macaque striate cortex

Published online by Cambridge University Press:  20 October 2015

DANIEL L. ADAMS ,
JOHN R. ECONOMIDES  and
JONATHAN C. HORTON
DANIEL L. ADAMS
Affiliation:
Beckman Vision Center, University of California, San Francisco, California 94143 Center for Mind/Brain Sciences, The University of Trento, Trento, Italy
JOHN R. ECONOMIDES
Affiliation:
Beckman Vision Center, University of California, San Francisco, California 94143
JONATHAN C. HORTON*
Affiliation:
Beckman Vision Center, University of California, San Francisco, California 94143
*
*Address correspondence to: Jonathan C. Horton MD, PhD, Beckman Vision Center, University of California, San Francisco, 10 Koret Way, San Francisco, CA 94143-0730. E-mail: [email protected]
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Abstract

The patches in primary visual cortex constitute hot spots of metabolic activity, manifested by enhanced levels of cytochrome oxidase (CO) activity. They are also labeled preferentially by immunostaining for glutamic acid decarboxylase (GAD), γ-aminobutyric acid (GABA), and parvalbumin. However, calbindin shows stronger immunoreactivity outside patches. In light of this discrepancy, the distribution of the vesicular GABA transporter (VGAT) was examined in striate cortex of two normal macaques. VGAT immunoreactivity was strongest in layers 4B, 4Cα, and 5. In tangential sections, the distribution of CO, GAD, and VGAT was compared in layer 2/3. There was a close match between all three labels. This finding indicates that GABA synthesis is enriched in patches, and that inhibitory synapses are more active in patches than interpatches.

Keywords

Cytochrome oxidaseInhibitionOcular dominance columnGABAMacaquePrimary visual cortexV1Blob
Type
Brief Communication
Information
Visual Neuroscience , Volume 32 , 2015 , E026
Copyright
Copyright © Cambridge University Press 2015 

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