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Callosally projecting neurons in the macaque monkey V1/V2 border are enriched in nonphosphorylated neurofilament protein

Published online by Cambridge University Press:  02 June 2009

Patrick R. Hof ,
Leslie G. Ungerleider ,
Michelle M. Adams ,
Maree J. Webster ,
Ricardo Gattass ,
Dana M. Blumberg  and
John H. Morrison
Patrick R. Hof
Affiliation:
Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York Department of Ophthalmology, Mount Sinai School of Medicine, New York
Leslie G. Ungerleider
Affiliation:
Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda
Michelle M. Adams
Affiliation:
Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda
Maree J. Webster
Affiliation:
Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda Slanley Foundation Research Program, National Institute of Mental Health Neuroscience Center at St. Elizabeth's, Washington D.C.
Ricardo Gattass
Affiliation:
Departamento de Neurobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941–900, Brasil
Dana M. Blumberg
Affiliation:
Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York
John H. Morrison
Affiliation:
Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York
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Abstract

Previous immunohistochemical studies combined with retrograde tracing in macaque monkeys have demonstrated that corticocortical projections can be differentiated by their content of neurofilament protein. The present study analyzed the distribution of nonphosphorylated neurofilament protein in callosally projecting neurons located at the V1/V2 border. All of the retrogradely labeled neurons were located in layer III at the V1/V2 border and at an immediately adjacent zone of area V2. A quantitative analysis showed that the vast majority (almost 95%) of these interhemispheric projection neurons contain neurofilament protein immunoreactivity. This observation differs from data obtained in other sets of callosal connections, including homotypical interhemispheric projections in the prefrontal, temporal, and parietal association cortices, that were found to contain uniformly low proportions of neurofilament protein-immunoreactive neurons. Comparably, highly variable proportions of neurofilament protein-containing neurons have been reported in intrahemispheric corticocortical pathways, including feedforward and feedback visual connections. These results indicate that neurofilament protein is a prominent neurochemical feature that identifies a particular population of interhemispheric projection neurons at the V1/V2 border, and suggest that this biochemical attribute may be critical for the function of this subset of callosal neurons.

Keywords

Callosal projectionsCytoskeletonNeurochemical codingNeurofilament proteinPrimate visual system
Type
Research Articles
Information
Visual Neuroscience , Volume 14 , Issue 5 , September 1997 , pp. 981 - 987
Copyright
Copyright © Cambridge University Press 1997

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