Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-23T18:53:05.776Z Has data issue: false hasContentIssue false
  • English
  • Français

Activation of metabotropic glutamate receptors has different effects in different layers of cat visual cortex

Published online by Cambridge University Press:  02 June 2009

Silvia N.M. Reid  and
Nigel W. Daw
Silvia N.M. Reid
Affiliation:
Department of Ophthalmology and Visual Sciences, Yale University Medical School, New Haven
Nigel W. Daw
Affiliation:
Department of Ophthalmology and Visual Sciences, Yale University Medical School, New Haven
Get access Rights & Permissions [Opens in a new window]

Abstract

Single neurons were recorded in cat primary visual cortex, and the effect of iontophoresis of the metabotropic glutamate agonist 1S,3R-aminocyclopentane-1.3-dicarboxylic acid (ACPD) was observed. In nearly all cases (41/43), ACPD reduced the visual response. In some cases ACPD also reduced spontaneous activity (24/43), and in other cases ACPD increased spontaneous activity (18/43). Increases were generally seen in infragranular layers (V and VI), and decreases in supragranular layers (II and III). The reduction in the visual response was also largest in supragranular layers. We conclude that activation of metabotropic glutamate receptors has both facilitatory and depressive effects in visual cortex, and the effect depends on the layer of the cell recorded.

Keywords

Visual cortexMetabotropic glutamate receptorsCatLaminar distributionIontophoresis
Type
Research Articles
Information
Visual Neuroscience , Volume 14 , Issue 1 , January 1997 , pp. 83 - 88
Copyright
Copyright © Cambridge University Press 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Armstrong-James, M., Fox, K. & Millar, J. (1980). A method for etching the tips of carbon fibre microelectrodes. Journal of Neuroscience Methods 2, 431–432.Google Scholar
Baskys, A. (1994). Metabolropic Glutamate Receptors. Austin, Texas: R.G. Landes Company.Google Scholar
Burke, J.P. & Hablitz, J.J. (1994). Presynaptic depression of synaptic transmission mediated by activation of metabotropic glutamate receptors in rat neocortex. Journal of Neuroscience 14, 5120–5130.Google Scholar
Cahusac, P.M.B. (1994). Cortical layer-specific effects of the metabotropic glutamate receptor agonist 1S.3R-ACPD in rat primary somato-sensory cortex in vivo. European Journal of Neuroscience 6, 1505–1511.Google Scholar
Czepita, D., Daw, N.W. & Reid, S.N.M. (1996). Glycine at the NMDA receptor in cat visual cortex: Saturation and changes with age. Journal of Neurophysiology 75, 311–317.CrossRefGoogle ScholarPubMed
Fox, K., Sato, H. & Daw, N.W. (1989). The location and function of NMDA receptors in cat and kitten visual cortex. Journal of Neuroscience 9, 2443–2454.Google Scholar
Greene, C.C., Schwindt, P.C. & Grill, W.E. (1994). Properties and ionic mechanisms of a metabotropic glutamate receptor-mediated slow afterdepolarization in neocortical neurons. Journal of Neurophysiology 72, 693–704.CrossRefGoogle ScholarPubMed
Kato, N. (1994). Long-term depression requiring tACPD-receptor activation and NMDA-receptor blockade. Brain Research 665, 158–160.Google Scholar
Kelly, J.P. & Van Essen, D.C. (1974). Cell structure and function in the visual cortex of the cat. Journal of Physiology 238, 515–547.CrossRefGoogle ScholarPubMed
Pin, J.P. & Duvoisin, R. (1995). The metabotropic glutamate receptors: Structure and functions. Neuropharmacology 34, 1–26.Google Scholar
Reid, S.N.M., Romano, C., Hughes, T. & Daw, N.W. (1995 a). Immuno-histochemical study of two phosphoinositide-linked metabotropic glutamate receptors (mGluRlα and mGluR5) in the cal visual cortex before, during and after the peak of the critical period for eye-specific connections. Journal of Comparative Neurology 355, 470–478.Google Scholar
Reid, S.N.M., Romano, C., Hughes, T., Devlin, D. & Daw, N.W. (1995 b). Development of cAMP-linked metabotropic glutamate receptor (mGluR2/3) and dark-rearing influence on mGluRs (1, 2/3 and 5) in the cat visual cortex. Society for Neuroscience Abstracts 21, 2024.Google Scholar
Sato, H., Fox, K. & Daw, N.W. (1989). Effect of electrical stimulation of locus coeruleus on the activity of neurons in the visual cortex. Journal of Neurophysiology 62, 946–958.Google Scholar
Schoepp, D.D. & Conn, P.J. (1993). Metabotropic receptors in brain function and pathology. Trends in Pharmacological Sciences 14, 13–19.CrossRefGoogle ScholarPubMed
Sillito, A.M. (1984). Functional considerations of the operation of GABAergic inhibitory processes in the visual cortex. In Cerebral Cortex, ed. Jones, E.G. & Peters, A., pp. 91–117. New York: Plenum.Google Scholar
Sillito, A.M. & Murphy, P.C. (1987). The cholinergic modulation of cortical function. In Cerebral Cortex, ed. Jones, E.G. & Peters, A., pp. 161–185. New York: Plenum.CrossRefGoogle Scholar
Sladeczek, F., Momiyama, A. & Takahashi, T. (1993). Presynaptic inhibitory action of a metabotropic glutamate receptor agonist on excitatory transmission in visual cortical neurons. Proceedings of the Royal Society B (London) 253, 297–303.Google ScholarPubMed
Taylor, K.E. & Cahusac, P.M.B. (1994). The effects of the metabotropic glutamate receptor agonist 1S,3R-ACPD on neurones in the rat primary somatosensory cortex in vivo. Neuropharmacology 33, 103–108.Google Scholar
Wang, X.F. & Daw, N.W. (1996). Effects of ACPD on the response to NMDA and AMPA in different layers of rat visual cortex. Investigative Ophthalmology and Visual Science (Suppl.) 37, 5486.Google Scholar
Wang, Z. & McCormick, D.A. (1993). Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R-ACPD. Journal of Neuroscience 13, 2199–2216.Google Scholar