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Visual function in regenerating teleost retina following surgical lesioning

Published online by Cambridge University Press:  29 May 2007

ALLEN F. MENSINGER  and
MAUREEN K. POWERS
ALLEN F. MENSINGER
Affiliation:
Vision Research Center and Department of Psychology, Vanderbilt University, Nashville, Tennessee Department of Biology, University of Minnesota, Duluth, Minnesota
MAUREEN K. POWERS
Affiliation:
Vision Research Center and Department of Psychology, Vanderbilt University, Nashville, Tennessee Gemstone Vision Research Institute, Rodeo, California
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Abstract

Regeneration of the teleost retina following surgical extirpation of 25% to 100% of the neural retina was investigated in goldfish (Carrasius auratus) and sunfish (Lepomis cyanellus). The retina will regenerate following removal of up to 95% of the neural retina, however complete extirpation prevented regeneration. Visual sensitivity was assessed by examining components of the electroretinogram (ERG) and the dorsal light reflex (DLR) during regeneration. B-wave amplitudes in the experimental eyes increased throughout the study and central connections were reestablished as indicated by the progressive improvement in the dorsal light reflex. The recovery of visual function was closely correlated with retinal regeneration. Visual recovery progressed more slowly than following complete cytotoxic destruction of the mature retina (Mensinger & Powers, 1999) because the surgery removed a large number of the pluripotent cell population and restricted the number and distribution of regenerating foci.

Keywords

RegenerationRetinaVisionElectroretinogramPhotoreceptors
Type
Research Article
Information
Visual Neuroscience , Volume 24 , Issue 3 , May 2007 , pp. 299 - 307
Copyright
© 2007 Cambridge University Press

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