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Transcriptional regulation of nucleoredoxin-like genes takes place on a daily basis in the retina and pineal gland of rats

Published online by Cambridge University Press:  11 May 2015

TANJA WOLLOSCHECK ,
STEFANIE KUNST ,
DEBRA K. KELLEHER  and
RAINER SPESSERT
TANJA WOLLOSCHECK
Affiliation:
Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
STEFANIE KUNST
Affiliation:
Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
DEBRA K. KELLEHER
Affiliation:
Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
RAINER SPESSERT*
Affiliation:
Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
*
*Address correspondence to: Rainer Spessert, Department of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Saarstraße 19-21, 55099 Mainz, Germany. E-mail: [email protected]
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Abstract

The nucleoredoxin-like gene Nxnl1 (Txnl6) and its paralogue Nxnl2 encode the rod-derived cone viability factors (RdCVF and RdCVF2), which increase the resistance to photooxidative damage and have therapeutic potential for the survival of cones in retinitis pigmentosa. In this study, the transcription of Nxnl genes was investigated as a function of the day/night cycle in rats. The transcript levels of Nxnl1 and Nxnl2 were seen to display daily rhythms with steadily increasing values during the light phase and peak expression around dark onset in preparations of whole retina, photoreceptor cells and—but only in regard to Nxnl1—in photoreceptor-related pinealocytes. The cycling of Nxnl1 but not that of Nxnl2 persisted in constant darkness in the retina. This suggests that daily regulation of Nxnl1 is driven by a circadian clock, whereas that of Nxnl2 is promoted by environmental light. The present data indicate clock- and light-dependent regulations of nucleoredoxin-like genes that may be part of a protective shield against photooxidative damage.

Keywords

RatNucleoredoxin-like genesRod-derived cone viability factorRetinitis pigmentosaArylalkylamine N-Acetyltransferase
Type
Research Article
Information
Visual Neuroscience , Volume 32 , 2015 , E002
Copyright
Copyright © Cambridge University Press 2015 

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